Enstilar (Calcipotriene/Betamethasone Dipropionate)

Rx Prescription Required

Looking for a great price on Enstilar then visit our online pharmacy for low cost prescription medication. Did we mention that shipping is FREE!

Enstilar Aerosol Foam 50mcg/g 0.5mg/g
Betamethasone Dipropionate, Calcipotriene
Leo Pharma Inc.


Medically reviewed by Dr. Samuel Maaiah, PharmD

Last updated: April 10, 2024

Dr. Maaiah is a PharmD graduate who has practiced both in pharmaceutical consulting and retail pharmacy. His interests include consulting and the development and approval of new therapeutics. He currently works as a Medical Information Consultant (MIC) and as a retail pharmacist. As a MIC he helps pharmaceutical companies with projects and by consulting as a medical information expert.

When Dr. Maaiah is not working, he enjoys spending time with his family and friends, doing outdoor activities, working out, and reading.

Order Online

How to buy Enstilar (Betamethasone and Calcipotriene) online?

Enstilar can be ordered online through CanadianPharmacyOnline.com or by calling 1-800-828-4489 and speaking to customer support. The chat feature can also be used for support. For more information please visit the “How to Order” page.

Is a prescription required?

Yes, a valid prescription from your doctor is required. Enstilar is a prescription medication and can only be sold with a prescription. To process your order, you will need to submit a prescription. The prescription can be emailed ([email protected]), faxed (1-800-416-8019), or uploaded. Alternatively, we can reach out to your doctor to attain a valid prescription if you would like.

What is the maximum amount that can be ordered?

A 3-month supply (90-days) is the maximum amount that can be ordered at one time. Refills are kept on file for future orders. The amount that can be ordered will be based on the directions and quantity indicated on the prescription from your provider.

Is it safe to order online from Canadian Pharmacy Online?

Absolutely. All our partner pharmacies are fully licensed and certified in their respective countries. We ensure that your shopping experience is safe and secure with our Norton Shopping Guarantee. We operate just like your local pharmacy would, with our main priority being to provide you access to safe and affordable prescription medication.

Enstilar Cost

How much does Enstilar (Betamethasone and Calcipotriene) cost?

Enstilar 50mcg/0.5mg – 60g (Brand)

  • Average US retail price – $1418.36
  • Our Price – $455.00

Above shows the price comparisons between the average U.S. retail price and Canadian Pharmacy Online price for a 60 g quantity of brand Enstilar 50mcg/0.5mg.

What is the lowest price of Enstilar per unit?

Lowest Price Per Unit: $7.58/unit for Enstilar (Betamethasone and Calcipotriene) foam

Is this price for Enstilar without insurance?

The above listed prices are without insurance. Unfortunately, we cannot accept insurance. However we will give you an official receipt in case it can qualify for a reimbursement from your insurer. We are also unable to adjudicate with U.S. insurance providers.

Why is Enstilar cheaper from Canada than from the United States?

Prices of medications ordered from Canada are regulated. This differs from the US as it is a free market economy and pharmaceutical suppliers can charge what they deem a product is worth. As a result, we can offer lower prices to our patients as we source medications from these countries.

Enstilar Coupon

Is there an Enstilar coupon available?

Sorry, we do not have an Enstilar coupon available at this time.

Enstilar Generic

Is there a lower cost generic Enstilar available?

Enstilar is not available as a generic alternative.

How much cheaper is generic Enstilar?

There is currently no generic alternative to Enstilar.  

What is the difference between brand and generic Enstilar?

Once available on the market, there will be no difference between generic and brand Enstilar. Generic formulations of medications contain the same active ingredients and meet the same quality, strength, and purity standards as the brand formulation.


Is shipping available to the United States?

Yes. Your Enstilar will be shipped from Canada to the U.S within 7 to 10 business days. An email notification will be sent to you once the item has been shipped. There are no shipping charges.

Is express shipping available?

Yes. You have the option at the checkout page to select the express shipping option ($25).

Refill Rx

How to refill a prescription?

Refilling your prescription is made easy with Canadian Pharmacy Online. You can sign into your online account and view your previous orders and see which prescriptions we have on file. Placing a refill order online is made simple by accessing the reorder section in your account.

You can also call us at 1-800-416-8019 and speak to customer support to place a refill. Our live chat is also a great place to connect with us to place a refill order while you are on the go.

Are prescriptions automatically refilled?

We do not automatically refill prescriptions as there can be cases where you are no longer taking the medication, your doctor has changed your dose, etc. However, we provide a friendly refill reminder service. We will kindly notify you by phone or email as to the best time to place a refill order based on your prescription history.

Drug Information

About Enstilar (Calcipotriene/Betamethasone)

What is Enstilar? 

Enstilar is a prescription medication that is classified as a topical corticosteroid (betamethasone) and vitamin D analog (calcipotriene).


What is Enstilar used for? 

It is used for the treatment of plaque psoriasis. The foam formulation is indicated for patients 12 years of age and up.

How does it work?

The calcipotriol component induces differentiation and suppresses proliferation of keratinocytes, which reverses the abnormal keratinocyte changes in psoriasis. The betamethasone component has anti-inflammatory, antipruritic, and vasoconstrictive effects.


How to apply Enstilar?

Wash your hands before applying Enstilar.

  • Step 1) Prior to use, shake the medication. Gently rub the foam into the affected area.
  • Step 2) Hold the Enstilar can at least 1.5 inches away from the affected area.
  • Step 3) You can spray the foam holding the can in all positions except horizontally.
  • Step 4) Gently rub the foam into the affected area as instructed by your doctor. Repeat to any other affected areas.
  • Step 5) Place back the cap after application.
  • Step 6) Be sure to wash your hands after applying the Enstilar foam.

Do not apply to the axillae, face, groin, or on skin with preexisting skin atrophy at the affected site.

This medication is not for intravaginal, ophthalmic, or oral use.

Do not use any occlusive dressing after application unless directed by your doctor.

What dosages are available?

Enstilar is only available at an external foam agent (betamethasone dipropionate 0.0064% and calcipotriene 0.005%; 60 g).

What is the recommended dosage?

Apply the spray foam to the affected area once daily.

What is the maximum dosage?

Do not exceed 60g every 4 days.

What if I miss a dose?

Take the medication as soon as possible if you have missed a dose. If it is almost time for your next dose, skip the missed dose and return back to your regular schedule. Never double the doses.

Warnings & Precautions

What should you know before you take Enstilar?

The foam formulation contains flammable propellants. Use should be avoided around flame, fire, and smoking during or right after the medication application.

Adrenal suppression may occur, particularly in younger patients or patients receiving high doses for a long period of time, on altered skin barrier, under occlusion, or use over a large surface area, and patients with hepatic dysfunction. If HPA axis suppression occurs, stopping Enstilar, decreasing application frequency, or using a less potent corticosteroid should be attempted. HPA axis suppression is usually reversible.
Allergic contact dermatitis can occur. Further evaluation may be necessary.

Caution in patients with known or suspected any calcium metabolism disorders.

There have been case reports of Kaposi sarcoma in patients with prolonged treatment of corticosteroids. If this occurs, Enstilar therapy should be stopped.

Avoid contact with eyes as posterior subcapsular cataracts and glaucoma have been reported with topical corticosteroids. Monitor for visual symptoms.

Local adverse side effects can occur, such as burning, atrophy, allergic contact dermatitis, striae, telangiectasis, itching, dryness, irritation, acneiform eruptions, folliculitis, perioral dermatitis, hypopigmentation, secondary infections, and miliaria. The risk is increased with prolonged use, occlusive use, or use of higher potency corticosteroids.

Absorption of topical corticosteroids can cause glycosuria, hyperglycemia, or Cushing’s syndrome.

Skin infections should be treated with appropriate antifungal or antibacterial agents. If the infection does not go away, stop Enstilar until the infection resolves.

Avoid excessive exposure of the treated/affected skin from natural or artificial lighting due to photosensitivity.

Systemic absorption of topical corticosteroids may cause hyperglycemia or unmasking of latent diabetes mellitus.

It is unknown whether Enstilar is excreted into breast milk.

Side Effects

What are the side effects of Enstilar? 

Some common side effects include:

  • HPA-axis suppression
  • Pruritus, erythema of the skin, psoriasis, skin atrophy
  • Headache
  • Upper respiratory tract infection

Speak to your doctor for a full list of side effects that apply to you if you are taking Enstilar.


Does this medication interact with other drugs, foods, or alcohol?

Avoid aldesleukin, aluminum hydroxide multivitamins/fluoride with ADE, multivitamins/Minerals with ADEK, folate, or iron, sucralfate, and vitamin D analogs (Risk Category X).

This is not a full list of potential drug-drug-interactions. Speak to your doctor if you have any concerns about drug-drug-interactions.


How should this medication be stored?

Your Enstilar should be stored between 20°- 25°C (68° – 77°F). Excursions are allowed to be stored between 15° – 30°C (59° – 86°F).

Do not freeze or expose to heat.

Do not store at temperatures above 49°C (120°F).

Do not incinerate or puncture.

After opening Enstilar, it should be used within 6 months.

Pharmacist Tips

  • The foam agent is flammable, so avoid flame, fire, and smoking during or right after medication application. Do not freeze your Enstilar or expose to heat or extreme temperatures.
  • The medication should be taken prior to every application.
  • After applying Enstilar, you must wash your hands thoroughly.
  • The foam can be sprayed out from any position except horizontally.
  • Do not wrap or occlude the affected area after applying your Enstilar.
  • After opening, you should use your Enstilar within 6 months.

The above information is an educational aid only. It is not intended as medical advice for individual conditions or treatments. Talk to your doctor, nurse or pharmacist before following any medical regimen to see if it is safe and effective for you.


Save $10 on your first order!
Enter Canadian Pharmacy Online coupon code CPO10 to save $10 off your order. Minimum $50 order value. *Coupon codes are one-time use and cannot be combined.

Enstilar FAQ

Q: Is Enstilar foam a corticosteroid?

Yes. Enstilar contains a corticosteroid (betamethasone) and vitamin D analog (calcipotriene).

Q: Is Enstilar foam a biologic?

No. It is made up of a corticosteroid (betamethasone) and vitamin D analog (calcipotriene).

Q: Is Enstilar safe in pregnancy?

If starting Enstilar in pregnancy, treatment is still initiated conservatively. If a topical steroid is needed, a low to moderate corticosteroid is preferred initially and can be followed by a moderate to higher potency agent. Some sources do not recommend the use of Enstilar for the treatment of psoriasis in pregnant women. Others recommend limiting the exposure of Enstilar to 50 g or less/week for 3 to 4 weeks or less. It is important to discuss the risk vs benefit of Enstilar with your provider if you are or may become pregnant.

Q: Is Enstilar good for eczema?

It does not have a FDA-labeled indication for the treatment of eczema.

Q: What does Enstilar treat?

It is used to treat plaque psoriasis in patients 12 years of age and up.

The above information is an educational aid only. It is not intended as medical advice for individual conditions or treatments. Talk to your doctor, nurse or pharmacist before following any medical regimen to see if it is safe and effective for you.