Combigan (Brimonidine/Timolol)

Rx Prescription Required

Buy Combigan (Brimonidine/Timolol) 0.2%/0.5% online from Save up to 90% and have your Rx shipped to your home.

Combigan 0.2%/0.5%
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Medically reviewed by Dr. Samuel Maaiah, PharmD

Last updated: February 9, 2022

Dr. Maaiah is a PharmD graduate who has practiced both in pharmaceutical consulting and retail pharmacy. His interests include consulting and the development and approval of new therapeutics. He currently works as a Medical Information Consultant (MIC) and as a retail pharmacist. As a MIC he helps pharmaceutical companies with projects and by consulting as a medical information expert.

When Dr. Maaiah is not working, he enjoys spending time with his family and friends, doing outdoor activities, working out, and reading.

Online Order

How to buy Combigan (Brimonidine/Timolol) online?

Combigan can be ordered online through or by calling 1-800-828-4489 and speaking to customer support. The chat feature can also be used for support. For more information please visit the “How to Order” page on

Is a prescription required?

Yes, a valid prescription from your doctor is required. Combigan is a prescription medication and can only be sold with a prescription. To process your order, you will need to submit a prescription. The prescription can be emailed ([email protected]), faxed (1-800-416-8019), or uploaded. Alternatively, we can reach out to your doctor to attain a valid prescription if you would like

What is the maximum amount that can be ordered?

A 3-month supply (90-days) is the maximum amount that can be ordered at one time. Refills are kept on file for future orders. The amount that can be ordered will be based on the directions and quantity indicated on the prescription from your doctor.

Is it safe to order from Canadian Pharmacy Online?

Absolutely. All our partner pharmacies are fully licensed and certified in their respective countries. We ensure that your shopping experience is safe and secure with our Norton Shopping Guarantee. We operate just like your local pharmacy would, with our main priority being to provide you access to safe and affordable prescription medication.

Combigan Cost

How much does Combigan cost?

Combigan 0.2%/0.5% – (5mL = 1 bottle)

  • Average US retail price – $235.35
  • Our Price – $5.000

Above shows the price comparison between a 5 mL quantity of Combigan 0.2%/0.5% at average U.S. retail price and Canadian Pharmacy Online Price.

At, we make sure to keep drug prices low and you can view the Combigan cost savings below:

We offer brand Combigan here at Canadian Pharmacy Online. A quantity of 1 bottle costs $50.00 which comes out to $10.00 per unit.

What is the lowest price of Combigan per unit?

Lowest Price Per Unit: $5.33/unit is the lowest price per unit for Combigan 0.2%/0.5%.

Is this price for Combigan without insurance?

The above listed prices are without insurance. Unfortunately, we cannot accept insurance. However we will give you an official receipt in case it can qualify for a reimbursement from your insurer. We are also unable to adjudicate with U.S. insurance providers.

Why is Combigan cheaper from Canada than from the United States?

Drug prices from Canada and other countries we source medication are regulated. This differs from the US as it is a free market economy and pharmaceutical suppliers can charge what they deem a product is worth. As a result, we can offer lower prices to our patients as we source medications from these countries.

Combigan Coupon

Is there a coupon for Combigan available?

Yes, we do you have a Combigan coupon for an extra discount on your prescription. You can save $10 off your order with coupon code COMBIGAN10. Apply coupon at checkout for instant savings and pay less for your prescription with a minimum $50 order.

Combigan Generic

Is there a lower cost generic Combigan available?

Yes, Combigan is available as a lower cost generic, Brimonidine tartrate/Timolol Maleate 0.2%/0.5%.

How much cheaper is the generic Combigan?

Generic Combigan (Brimonidine/Timolol) is about 40-60% cheaper than the brand option.

What is the difference between brand and generic Combigan?

The manufacturer of brand medication is Allergen based out of Ireland and the manufacturer of generic is Cipla Ltd out of India. Both are considered therapeutically equivalent. Generic formulations of medications contain the same active ingredients and meet the same quality, strength, and purity standards as the brand formulation.


Is shipping available to the United States?

An email notification will be sent to you once the item has been shipped. We ship nationwide across the United States.

How much does shipping cost?

Standard Shipping is free.

Is express shipping available?

If a product of Canada is available then express shipping can be selected with an estimated delivery time of 3-5 business days. You have the option at the checkout page to select the express shipping option ($25) if available for that medication source.

Refill Rx

How to refill a prescription?

Refilling your prescription is made easy with Canadian Pharmacy Online. You can sign into your online account and view your previous orders and see which prescriptions we have on file. Placing a refill order online is made simple by accessing the reorder section in your account.

You can also call us and speak to customer support to place a refill. Our live chat is also a great place to connect with us to place a refill order while you are on the go.

Are prescriptions automatically refilled?

We do not automatically refill prescriptions as there can be cases where you are no longer taking the medication, your doctor has changed your dose, etc. However, we provide a friendly refill reminder service. We will kindly notify you by phone or email as to the best time to place a refill order based on your prescription history.

Drug Information

About Combigan (Brimonidine/Timolol)

What is Combigan? 

Combigan is a prescription medication that is classified as a combination of two agents, brimonidine (alpha2 agonist) and timolol (nonselective beta-blocker).


What is Combigan used for? 

It is used for the treatment of elevated intraocular pressure (IOP) in patients with ocular hypertension or glaucoma who require adjunctive/replacement therapy due to inadequate control of IOP.

How does it work?

It decreases aqueous humor production and formation to lower intraocular pressure. It also exerts its effect by decreasing the synthesis of cyclic AMP.


How to use Combigan?

  • Before administering your Combigan, be sure to remove your contact lenses (if you wear them) prior. If you plan on reinserting your contact lenses, wait at least 15 minutes after your Combigan administration to do so. 
  • If administering other ophthalmic agents, be sure to wait at least 5 minutes or more between administrations.

What dosages are available?

Combigan comes in 0.2%/0.5%  ophthalmic solution (5mL, 10mL, 15mL). Combigan only comes as a brand name.

What is the recommended dosage?

The recommended dosage is one drop in the affected eye(s) twice a day, about 12 hours apart.

What is the maximum dosage?

The max dosage is one drop in the affected eye(s) twice a day.

What if you miss a dose?

Take the medication as soon as possible if you have missed a dose. If it is almost time for your next dose, skip the missed dose and return back to your regular schedule. Never double the doses.

Warnings & Precautions

What should you know before you take Combigan?

Combigan contains benzalkonium chloride. Be sure to remove your contact lenses prior to medication administration and wait at least 15 minutes before reinserting your contact lenses.

Caution in patients with diabetes mellitus as it may cause hypoglycemia and/or mask the signs/symptoms.

Side Effects

What are the side effects of Combigan?

Some common side effects include:

  • Drowsiness
  • Allergic conjunctivitis, eye pruritus, burning sensation of the eyes, stinging of the eyes, follicular conjunctivitis 

Speak to your doctor for a full list of side effects that apply to you if you are taking Combigan.


Does this medication interact with other drugs, foods, or alcohol?

Avoid use with azelastine, beta2-agonists, etofylline, fexinidazole, mianserin, orphenadrine, oxomemazine, paraldehyde, rivastigmine, thalidomide, and white birch allergen extract. (Risk Category X).

This is not a full list of potential drug-drug-interactions. Speak to your doctor if you have any concerns about drug-drug-interactions.


How should this medication be stored?

Combigan should be protected from light and stored at 15°-25°C (59°-77°F). Do not refrigerate.

Pharmacist Tips

  • If you wear contacts, remove your contacts prior to medication administration and wait at least 15 minutes before inserting them.
  • If administering more than on ophthalmic medication, wait at least 5 minutes between medication administration. 
  • Do not touch the tip of the eye dropper to avoid contamination.

The above information is an educational aid only. It is not intended as medical advice for individual conditions or treatments. Talk to your doctor, nurse or pharmacist before following any medical regimen to see if it is safe and effective for you.


Combigan Coupon
Use Combigan coupon code to get $10 discount. Minimum $50 purchase required.

Combigan FAQ

Q: Does Combigan lower blood pressure?

Combigan lowers the pressure in the eye but can also decrease your blood pressure.

Q: Does Combigan cause dry eyes?

Combigan can cause dry eyes.

Q: Does Combigan need to be refrigerated?

No. Do not refrigerate Combigan. It should be stored at 15°-25°C (59°-77°F) per the package insert.

Q: Does combigan cause dry mouth?

It can cause dry mouth as one of its side effects.

The above information is an educational aid only. It is not intended as medical advice for individual conditions or treatments. Talk to your doctor, nurse or pharmacist before following any medical regimen to see if it is safe and effective for you.