Motegrity (Prucalopride Succinate)

Rx Prescription Required

Select your dosage below to view Motegrity cost and place your order. Save up to 90% and get FREE standard shipping on prescription medication delivered to your door.

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Medically reviewed by Dr. Samuel Maaiah, PharmD

Last updated: February 11, 2022

Dr. Maaiah is a PharmD graduate who has practiced both in pharmaceutical consulting and retail pharmacy. His interests include consulting and the development and approval of new therapeutics. He currently works as a Medical Information Consultant (MIC) and as a retail pharmacist. As a MIC he helps pharmaceutical companies with projects and by consulting as a medical information expert.

When Dr. Maaiah is not working, he enjoys spending time with his family and friends, doing outdoor activities, working out, and reading.

Order Online

How to buy Motegrity (Prucalopride) online?

Motegrity (Prucalopride) can be ordered online through or by calling 1-800-828-4489 and speaking to customer support. The chat feature can also be used for support. For more information please visit the “How to Order” page.

Is a prescription required?

Yes, a valid prescription from your doctor is required. Motegrity (Prucalopride) is a prescription medication and can only be sold with a prescription. To process your order, you will need to submit a prescription. The prescription can be emailed ([email protected]), faxed (1-800-416-8019), or uploaded. Alternatively, we can reach out to your doctor to attain a valid prescription if you would like.

What is the maximum amount that can be ordered?

A 90-day supply is the maximum amount that can be ordered at one time. The amount that can be ordered will be based on the directions and quantity indicated on the prescription from your provider. Refills are kept on file for future orders.

Is it safe to order from Canadian Pharmacy Online?

Absolutely. All our partner pharmacies are fully licensed and certified in their respective countries. We ensure that your shopping experience is safe and secure with our Norton Shopping Guarantee. We operate just like your local pharmacy would, with our main priority being to provide you access to safe and affordable prescription medication.

Motegrity Cost

How much does Motegrity (Prucalopride) cost?

Motegrity 2mg –

  • Average US retail price (20 Tablets) – $546.00
  • Our Price (28 Tablets) – $144.00

At, we make sure to keep drug prices low.

You can view the Motegrity (Prucalopride) cost savings above with the price comparison Motegrity between the average U.S. retail price and Canadian Pharmacy Online price.

What is the lowest price of Motegrity (Prucalopride) per unit?

Lowest Price Per Unit: $4.04/unit for Motegrity (Prucalopride) 2mg tablets 

Is this price for Motegrity (Prucalopride) without insurance?

The prices mentioned above are without insurance. Unfortunately, we are not able to process insurance claims. However, we will give you an official receipt that you can use to apply for reimbursement with your insurer. We are unable to adjudicate with US insurance providers.

Why is Motegrity (Prucalopride) cheaper from Canada than from the United States?

The cost of medications ordered from India, Canada, and Turkey are internally controlled by the respective governments. The US is a free market economy which is why the price differs since pharmaceutical suppliers can charge what they consider appropriate for the product. As a result, we can offer lower prices to our patients as we receive medications from these countries.

Motegrity Coupon

Is there an Motegrity (Prucalopride) coupon available?

Sorry, we do not have an Motegrity (Prucalopride) coupon available at this time.

Motegrity Generic

Is there a lower cost generic Motegrity (Prucalopride) available?

Motegrity (Prucalopride) is not available as a generic alternative.

How much cheaper is generic Motegrity (Prucalopride)?

There is currently no generic alternative to Motegrity.

What is the difference between brand and generic Motegrity (Prucalopride)?

Once available on the market, there will be no difference between generic and brand Motegrity. Generic formulations of medications contain the same active ingredients and meet the same quality, strength, and purity standards as the brand formulation.


Is shipping available to the United States?

Yes.  An email notification will be sent to you once the item has been shipped. We ship nationwide across the United States.

How much does shipping cost?

Standard shipping is free.

Is express shipping available?

If a product of Canada is available then express shipping can be selected with an estimated delivery time of 3-5 business days. You have the option at the checkout page to select the express shipping option ($25) if available for that medication source.

Refill Rx

How to refill a prescription?

Refilling your prescription is made easy with Canadian Pharmacy Online. You can sign into your online account and view your previous orders and see which prescriptions we have on file. Placing a refill order online is made simple by accessing the reorder section in your account.
You can also call us at 1-800-416-8019 and speak to customer support to place a refill. Our live chat is also a great place to connect with us to place a refill order while you are on the go.

Are prescriptions automatically refilled?

We do not automatically refill prescriptions as there can be cases where you are no longer taking the medication, your doctor has changed your dose, etc. However, we provide a friendly refill reminder service. We will kindly notify you by phone or email as to the best time to place a refill order based on your prescription history.

Drug Information

About Motegrity (Prucalopride Succinate)

What is Motegrity (Prucalopride)?

Motegrity (Prucalopride) is a prescription medication that is classified as serotonin 5-HT4 receptor agonist.


What is Motegrity used for? 

It is used for the treatment of chronic idiopathic constipation in adults. 

How does it work?

It acts as an agonist at the serotonin type 4 receptor which results in gastrointestinal prokinetic stimulation that increases colonic motility.


How do I take Motegrity (Prucalopride)?

Take Motegrity (Prucalopride) by mouth with or without food as directed by your doctor. 

What dosages are available?

Motegrity (Prucalopride) is only available as a brand in 1mg and 2mg tablets.

What is the recommended dosage?

It is typically dosed 2mg once daily but take as directed by your doctor.

What is the maximum dosage?

The maximum recommended dosage is 2mg/day.

What if I miss a dose?

Take the medication as soon as possible if you have missed a dose. If it is almost time for your next dose, skip the missed dose and return back to your regular schedule. Never double the doses.

Warnings & Precautions

What should you know before you take Motegrity (Prucalopride)?

There is limited information with use in pregnancy. Consider the use of appropriate contraception in females of reproductive age.

Caution in renal dysfunction. Dose adjustment may be needed.

  • CrCl 30 mL/min or more: No dose adjustment.
  • CrCl < 30 mL/min: 1 mg/daily 
  • ESRD needing hemodialysis: Avoid use. 

Use may cause fatigue and dizziness. Inform patients about performing tasks requiring mental alertness. 

Can cause diarrhea or severe diarrhea, most often reported to occur during the first week of treatment, resolving within a few days. If persistent diarrhea occurs, stop Motegrity (Prucalopride) and speak to a healthcare provider. 

Suicidal ideation, suicide attempts, and suicide have been reported with use. Monitor patients carefully for any new onset or persistent worsening of depression or development of suicidal thoughts. 

Caution in the elderly population. 

Side Effects

What are the side effects of Motegrity (Prucalopride)?

Some common side effects include:

  • Abdominal pain, nausea, diarrhea, severe diarrhea
  • Headache
  • Abdominal distention, flatulence, vomiting
  • Dizziness

Speak to your doctor for a full list of side effects that apply to you if you are taking Motegrity (Prucalopride).


Does this medication interact with other drugs, foods, or alcohol?

Use with anticholinergic agents or opioid agonists may decrease the therapeutic effect of Motegrity (Prucalopride) (Risk Category C).

This is not a full list of potential drug-drug-interactions. Speak to your doctor if you have any concerns about drug-drug-interactions.


How should this medication be stored?

Motegrity (Prucalopride) should be stored between 20°C to 25°C (68°F to 77°F). Excursions are allowed to be stored between 15°C to 30°C (between 59°F to 86°F)

Pharmacist Tips

  • Diarrhea and severe diarrhea can occur, reported mostly during the first week and should go away after a few days. If it does not, stop Motegrity (Prucalopride) and speak to a healthcare provider. 

The above information is an educational aid only. It is not intended as medical advice for individual conditions or treatments. Talk to your doctor, nurse or pharmacist before following any medical regimen to see if it is safe and effective for you.


Save $10 on your first order!
Enter Canadian Pharmacy Online coupon code CPO10 to save $10 off your order. Minimum $50 order value. *Coupon codes are one-time use and cannot be combined.

Motegrity FAQ

Is Motegrity (Prucalopride) an antidepressant?


Is Motegrity (Prucalopride) SSRI?

No. Prucalopride is a serotonin 5-HT4r receptor agonist. 

Is Motegrity (Prucalopride) a laxative?


Does Motegrity (Prucalopride) cause diarrhea?

Diarrhea is listed as a side effect of Prucalopride, most often reported to occur in the first week of drug administration, subsiding in a few days.

Is Motegrity (Prucalopride) FDA-approved?

Prucalopride is FDA-approved for the treatment of chronic idiopathic constipation in adults. 

The above information is an educational aid only. It is not intended as medical advice for individual conditions or treatments. Talk to your doctor, nurse or pharmacist before following any medical regimen to see if it is safe and effective for you.