Premarin (Conjugated Estrogens)

Rx Prescription Required

Select your dosage below to view Premarin cost and place your order. Save up to 90% and get FREE standard shipping on prescription medication delivered to your door.

Premarin 0.3mg
Conjugated Estrogens
Pfizer Inc
Premarin 0.625mg
Conjugated Estrogens
Pfizer Inc
Premarin 1.25mg
Conjugated Estrogens
Pfizer Inc
Premarin 0.3mg
Estrogens, Conjugated
Pfizer Inc
Premarin 0.625mg
Estrogens, Conjugated
Pfizer Inc
Premarin 1.25mg
Estrogens, Conjugated
Pfizer Inc


Medically reviewed by Dr. Samuel Maaiah, PharmD

Last updated: April 10, 2024

Dr. Maaiah is a PharmD graduate who has practiced both in pharmaceutical consulting and retail pharmacy. His interests include consulting and the development and approval of new therapeutics. He currently works as a Medical Information Consultant (MIC) and as a retail pharmacist. As a MIC he helps pharmaceutical companies with projects and by consulting as a medical information expert.

When Dr. Maaiah is not working, he enjoys spending time with his family and friends, doing outdoor activities, working out, and reading.

Order Online

How to buy Premarin (Estrogen) online?

Premarin (Estrogen) can be ordered online through or by calling 1-800-828-4489 and speaking to customer support. The chat feature can also be used for support. For more information please visit the “How to Order” page.

Is a prescription required?

Yes, a valid prescription from your doctor is required. Premarin (Estrogen) is a prescription medication and can only be sold with a prescription. To process your order, you will need to submit a prescription. The prescription can be emailed ([email protected]), faxed (1-800-416-8019), or uploaded. Alternatively, we can reach out to your doctor to attain a valid prescription if you would like.

What is the maximum amount that can be ordered?

A 3-month supply (90 days) is the maximum amount that can be ordered at one time. Refills are kept on file for future orders. The amount that can be ordered will be based on the directions and quantity indicated on the prescription from your provider.

Is it safe to order from Canadian Pharmacy Online?

Absolutely. All our partner pharmacies are fully licensed and certified in their respective countries. We ensure that your shopping experience is safe and secure with our Norton Shopping Guarantee. We operate just like your local pharmacy would, with our main priority being to provide you access to safe and affordable prescription medication.

Premarin Cost

How much does Premarin (Estrogen) cost?

Premarin 0.625mg –

  • Average US retail price (90 Tablets) – $774.00
  • Our Price (84 Tablets) – $55.00

At, we make sure to keep drug prices low.

You can view the Premarin (Estrogen) cost savings above with the price comparison of Premarin between the average U.S. retail price and Canadian Pharmacy Online price.

What is the lowest price of Premarin (Estrogen) per unit?

Lowest Price Per Unit: $0.65/unit for Premarin (Estrogen) 0.625mg tablets 

Is this price for Premarin (Estrogen) without insurance?

The listed prices are without insurance. Unfortunately, we do not accept insurance. However, we will give you an official receipt which you can use to apply for reimbursement with your insurer. We are unable to adjudicate with US insurance providers.

Why is Premarin (Estrogen) cheaper from Canada than from the United States?

The prices of medications ordered from Canada are lower as drug prices are negotiated and regulated. The US is a free market economy which is how the price differs since pharmaceutical suppliers can charge what they determine to be appropriate for the product. As a result, we can offer lower prices to our patients as we utilize medications from these countries. 

Premarin Coupon

Is there a coupon for Premarin available?

Yes, we do you have a Premarin coupon for an extra discount on your prescription. You can save $10 off your order with coupon code PREMARIN10. Apply coupon at checkout for instant savings and pay less for your prescription with a minimum $50 order. This online coupon can be applied to any dosage.

Premarin Generic

Is there a lower cost generic Premarin (Estrogen) available?

Premarin (Estrogen) is not available as a generic alternative.

How much cheaper is generic Premarin (Estrogen)?

There is currently no generic alternative to Premarin.

What is the difference between brand and generic Premarin (Estrogen)?

Once available on the market, there will be no difference between generic and brand Premarin. Generic formulations of medications contain the same active ingredients and meet the same quality, strength, and purity standards as the brand formulation.


Is shipping available to the United States?

Yes. An email notification will be sent to you once the item has been shipped. We ship nationwide across the United States.

How much does shipping cost?

Standard shipping is free.

Is express shipping available?

If a product of Canada is available then express shipping can be selected with an estimated delivery time of 3-5 business days. You have the option at the checkout page to select the express shipping option ($25) if available for that medication source.

Refill Rx

How to refill a prescription?

Refilling your prescription is made easy with Canadian Pharmacy Online. You can sign into your online account and view your previous orders and see which prescriptions we have on file. Placing a refill order online is made simple by accessing the reorder section in your account.
You can also call us at 1-800-416-8019 and speak to customer support to place a refill. Our live chat is also a great place to connect with us to place a refill order while you are on the go.

Are prescriptions automatically refilled?

We do not automatically refill prescriptions as there can be cases where you are no longer taking the medication, your doctor has changed your dose, etc. However, we provide a friendly refill reminder service. We will kindly notify you by phone or email as to the best time to place a refill order based on your prescription history.

Drug Information

About Premarin (Conjugated Estrogens)

What is Premarin (Estrogen)?

Premarin (Estrogen) tablets are a prescription medication that are classified as estrogen derivatives.


What is Premarin used for?

They are indicated for the treatment of metastatic breast cancer, hypoestrogenism in females, osteoporosis prevention in females, advanced prostate cancer, vasomotor symptoms associated with menopause, and vulvar and vaginal atrophy associated with menopause.

How does it work?

Through a negative feedback mechanism, it reduces the levels of luteinizing hormone (LH) and follicle stimulating hormone (FSH) in postmenopausal women.


How do I take Premarin (Estrogen)?

Take your Premarin (Estrogen) tablet by mouth at the same time every day with or without food.

What dosages are available?

Premarin (Estrogen) tablets are only available as a brand (0.3mg, 0.45mg, 0.625mg, 0.9mg, 1.25mg).

What is the recommended dosage?

It is typically dosed 0.3mg daily but take as directed by your doctor.

What is the maximum dosage?

The maximum recommended dosage is 30mg/day.

What if I miss a dose?

Take the medication as soon as possible if you have missed a dose. If it is almost time for your next dose, skip the missed dose and return back to your regular schedule. Never double the doses.

Warnings & Precautions

What should you know before you take Premarin (Estrogen)?

Anaphylaxis requiring emergency medical help has been reported within minutes to hours after taking the medication. Angioedema of the feet, hands, face, tongue, and larynx has also been reported.

Use may exacerbate endometriosis.

Use (estrogen compounds) has been associated with lipid effects (increased HDL-cholesterol and decreased LDL-cholesterol). Discontinue Premarin (Estrogen) is pancreatitis.

Available information with use of estrogen (menopausal estrogen or estrogen/progestin) therapy and risk of ovarian cancer are inconsistent.

Use may cause retinal vascular thrombosis.

Caution in those with asthma.

Use may cause impairment in glucose tolerance. Caution in those with diabetes. 

Use caution in those with diseases that may be exacerbated by fluid retention.

Use of postmenopausal estsrogen may increase the risk of gallbladder disease requiring surgery.

Caution in those with hepatic hemangiomas.

Caution in those with migraines.

Caution in females with hereditary angioedema. 

Caution in those with hepatic dysfunction.

Use may cause an increase in thyroid-binding globulin (TBG).

U.S. Boxed Warning: 

  • Endometrial cancer
    • Increased risk in those with a uterus who uses unopposed estrogens
  • Cardiovascular disease (CVD)
    • Estrogen-alone should not be used for the prevention of CVD
    • Estrogen plus progestin should not be used for the prevention of CVD
  • Breast cancer
    • A substudy has shown an increased risk of invasive breast cancer in estrogen-plus-progestin therapy
  • Dementia
    • Estrogen-alone should not be used for the prevention of dementia
    • Estrogen plus progestin should not be used for the prevention of dementia
  • Risk vs. benefits 
    • Weight the risk vs benefits
    • Estrogens with or without progestins should be used at the lowest effective dose for the shortest duration possible for the treatment goal/risks for the individual woman

Side Effects

What are the side effects of Premarin (Estrogen)?

Some common side effects include:

  • Headache, pain, depression, dizziness, nervousness
  • Abdominal pain, diarrhea, flatulence 
  • Vaginal hemorrhage, vaginitis, leukorrhea, vulvovaginal candida
  • Mastalgia, back pain, arthralgia, weakness, leg cramps
  • Pharyngitis, sinusitis, increased cough 
  • Pruritusq

Speak to your doctor for a full list of side effects that apply to you if you are taking Premarin (Estrogen).


Does this medication interact with other drugs, foods, or alcohol?

Avoid use with dehydroepiandrosterone, growth hormone analogs, hemin, indium 111, and ospemifene (Risk Category X).

This is not a full list of potential drug-drug-interactions. Speak to your doctor if you have any concerns about drug-drug-interactions. 


How should this medication be stored?

Your Premarin (Estrogen) tablets should be stored between 20° to 25°C (68° to 77°F). Excursions are allowed to be stored between 15° to 30°C (59° to 86°F).

Pharmacist Tips

  • If you plan or become pregnant, immediately stop the Premarin (Estrogen) therapy.

The above information is an educational aid only. It is not intended as medical advice for individual conditions or treatments. Talk to your doctor, nurse or pharmacist before following any medical regimen to see if it is safe and effective for you.


Premarin Coupon
Use Premarin coupon code to get $10 discount. Minimum $50 purchase required. *Coupon codes are one-time use and cannot be combined.

Premarin FAQ

Is Premarin (Estrogen) a steroid?

No. Premarin (Estrogen) is an estrogen derivative.

Is Premarin (Estrogen) just estrogen?

Premarin (Estrogen) is a conjugated estrogens (estrogen derivative).

Does Premarin (Estrogen) cause weight gain?

Premarin (Estrogen) can cause weight changes.

Is Premarin (Estrogen) a controlled substance?


Is Premarin (Estrogen) a prescription drug?


The above information is an educational aid only. It is not intended as medical advice for individual conditions or treatments. Talk to your doctor, nurse or pharmacist before following any medical regimen to see if it is safe and effective for you.