Vagifem (Estradiol)

Rx Prescription Required

Select your dosage below to view Vagifem cost and place your order. Save up to 90% and get FREE standard shipping on prescription medication delivered to your door.

Vagifem 10mcg
Estradiol Hemihydrate
Novo Nordisk
Estradiol 10mcg
Estradiol Hemihydrate
UK Various Generics
Vagifem 10mcg
Estradiol Hemihydrate
Novo Nordisk
Vagifem 10mcg
Estradiol Hemihydrate
Novo Nordisk

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Medically reviewed by Dr. Samuel Maaiah, PharmD

Last updated: February 13, 2022

Dr. Maaiah is a PharmD graduate who has practiced both in pharmaceutical consulting and retail pharmacy. His interests include consulting and the development and approval of new therapeutics. He currently works as a Medical Information Consultant (MIC) and as a retail pharmacist. As a MIC he helps pharmaceutical companies with projects and by consulting as a medical information expert.

When Dr. Maaiah is not working, he enjoys spending time with his family and friends, doing outdoor activities, working out, and reading.

Order Online

How to buy Vagifem (estradiol) online?

Vagifem (estradiol) can be ordered online through or by calling 1-800-828-4489 and speaking to customer support. The chat feature can also be used for support. For more information please visit the “How to Order” page.

Is a prescription required?

Yes, a valid prescription from your doctor is required. Vagifem (estradiol) is a prescription medication and can only be sold with a prescription. To process your order, you will need to submit a prescription. The prescription can be emailed ([email protected]), faxed (1-800-416-8019), or uploaded. Alternatively, we can reach out to your doctor to attain a valid prescription if you would like.

What is the maximum amount that can be ordered?

A 3-month supply (90 days) is the maximum amount that can be ordered at one time. Refills are kept on file for future orders. The amount that can be ordered will be based on the directions and quantity indicated on the prescription from your provider.

Is it safe to order from Canadian Pharmacy Online?

Absolutely. All our partner pharmacies are fully licensed and certified in their respective countries. We ensure that your shopping experience is safe and secure with our Norton Shopping Guarantee. We operate just like your local pharmacy would, with our main priority being to provide you access to safe and affordable prescription medication.

Vagifem Cost

How much does Vagifem (estradiol) cost?

Vagifem 10mcg (Brand) – 18 Tablets

  • Average US retail price – $487.98
  • Our price – $70.00

Estradiol 10mcg (Generic) – 24 Tablets

  • Average US retail price – $503.65
  • Our price – $70.00

At, we make sure to keep drug prices low. You can view the Vagifem (estradiol) cost savings above with the price comparison of brand and generic Vagifem 10mcg between the average U.S. retail price and Canadian Pharmacy Online price.

What is the lowest price of Vagifem (estradiol) per unit?

Lowest Price Per Unit: $3.67/unit for brand Vagifem 10mcg tablets

Is this price for Vagifem (estradiol) without insurance?

The listed prices are not with insurance. Unfortunately, we cannot accept insurance. However, we will give you an official receipt which you can use to apply for reimbursement with your insurance company. We are also unable to adjudicate with US insurance providers.

Why is Vagifem (estradiol) cheaper from Canada than from the United States?

Drug prices in Canada and from other countries we source medication from are negotiated and regulated. The US is a free market economy which is why the price differs since pharmaceutical suppliers can charge what they determine appropriate for the product. As a result, we can offer lower prices to our patients as we utilize medications from these countries. 

Vagifem Coupon

Is there a coupon for Vagifem available?

Yes, we do you have a Vagifem coupon for an extra discount on your prescription. You can save $10 off your order with coupon code VAGIFEM10. Apply coupon at checkout for instant savings and pay less for your prescription with a minimum $50 order.

Vagifem Generic

Is there a lower cost generic Vagifem (estradiol) available?

Vagifem (estradiol) is available as a generic alternative. 

How much cheaper is generic Vagifem (estradiol)?

Generic Vagifem (estradiol) is $35 cheaper than brand Vagifem.  

What is the difference between brand and generic Vagifem (estradiol)?

There is no difference between generic and brand Vagifem. Generic formulations of medications contain the same active ingredients and meet the same quality, strength, and purity standards as the brand formulation.


Is shipping available to the United States?

Yes. An email notification will be sent to you once the item has been shipped. We ship nationwide across the United States.

How much does shipping cost?

Standard shipping is free.

Is express shipping available?

If a product of Canada is available then express shipping can be selected with an estimated delivery time of 3-5 business days. You have the option at the checkout page to select the express shipping option ($25) if available for that medication source.

Refill Rx

How to refill a prescription?

Refilling your prescription is made easy with Canadian Pharmacy Online. You can sign into your online account and view your previous orders and see which prescriptions we have on file. Placing a refill order online is made simple by accessing the reorder section in your account.

You can also call us at 1-800-416-8019 and speak to customer support to place a refill. Our live chat is also a great place to connect with us to place a refill order while you are on the go.

Are prescriptions automatically refilled?

We do not automatically refill prescriptions as there can be cases where you are no longer taking the medication, your doctor has changed your dose, etc. However, we provide a friendly refill reminder service. We will kindly notify you by phone or email as to the best time to place a refill order based on your prescription history.

Drug Information

About Vagifem (Estradiol)

What is Vagifem (estradiol)? 

Vagifem (estradiol) is prescription medication that is classified as an estrogen or endocrine-metabolic agent.


What is Vagifem (estradiol) used for?

It is used to treat atrophic vaginitis due to menopause.

How does it work?

It reduces the levels of luteinizing hormone (LH) and follicle stimulating hormone (FSH) through a negative feedback mechanism in postmenopausal women. 


How do I take Vagifem (estradiol)?

You should take Vagifem (estradiol) as directed by your doctor. 

What dosages are available?

Vagifem (estradiol) is available in brand and generic 10 and 25mcg tablets 

What is the recommended dosage?

Generally patients will insert 1 tablet vaginally daily for 2 weeks then continue inserting 1 tablet twice weekly thereafter but take as directed by your doctor. 

What is the maximum dosage?

The maximum recommended dosage is 1.25mg/day.

What if I miss a dose?

If you miss a dose, take it as soon as you remember. If it is relatively close to when your next dose is due, wait until then and take a normal dose. Do not take an extra dose to make up for the missed dose. 

Warnings & Precautions

What should you know before you take Vagifem (estradiol)?

Estrogen can increase your risk of developing gallbladder disease 

If you experience high calcium levels, loss of vision, high triglycerides, or jaundice, you should discontinue Vagifem (estradiol) 

The application process may cause abrasions to the vagina.

Patients with a thyroid disorder should have their thyroid levels checked regularly on this medication. 

Side Effects

What are the side effects of Vagifem (estradiol)?

Some common (≥5%) side effects include:

  • Upper respiratory tract infection 
  • Headache 
  • Abdominal pain
  • Back pain
  • Genital pruritus 
  • Moniliasis
  • Vulvovaginal mycotic infection 
  • Diarrhea 

Speak to your doctor for a full list of side effects.


Does this medication interact with other drugs, foods, or alcohol?

Estrogens are metabolized by CYP3A4 enzymes so any medications that are inducers or inhibitors of this enzyme should be used with caution. 


How should this medication be stored?

Store Vagifem (estradiol) at room temperature. Keep it in the original single-use package until ready to use individually. 

Pharmacist Tips

  • For insertion instructions, refer to the package insert. If you have questions feel free to contact your pharmacist or doctor. 
  • If you experience any unusual vaginal bleeding while using this medication contact your healthcare provider. 
  • Estrogen products can increase your chance of stroke, however, given this medicine is inserted vaginally there is less risk than if it were taken orally.

The above information is an educational aid only. It is not intended as medical advice for individual conditions or treatments. Talk to your doctor, nurse or pharmacist before following any medical regimen to see if it is safe and effective for you.


Vagifem Coupon
Use Vagifem coupon code to get $10 discount. Minimum $50 purchase required. *Coupon codes are one-time use and cannot be combined.

Vagifem FAQ

Should I take Vagifem (estradiol) in the morning or at night?

There is no best time of day to use Vagifem (estradiol), it should be done at the same time each time. 

How long does it take Vagifem (estradiol) to dissolve?

Per the manufacturer, Vagifem (estradiol) should dissolve slowly over a few hours after insertion. 

What is the purpose of Vagifem (estradiol)?

Vagifem (estradiol) is used to treat women with atrophic vaginitis caused by menopause, it will help to relieve dryness and inflammation. 

Do you need progesterone with Vagifem (estradiol)?

As Vagifem (estradiol) is a vaginal estrogen preparation it does not require the concomitant use of progesterone as there is little systemic absorption. 

Can I use Vagifem (estradiol) 3 times a week?

You should use Estradiol as directed by your doctor, generally, the normal dosage initially is daily for 2 weeks and then you continue using 1 tablet intravaginally twice weekly thereafter.

The above information is an educational aid only. It is not intended as medical advice for individual conditions or treatments. Talk to your doctor, nurse or pharmacist before following any medical regimen to see if it is safe and effective for you.