Entresto (Sacubitril/Valsartan)

Rx Prescription Required

Order your Entresto prescription from Canadian Pharmacy Online and save money. Save up to 90%. Shop and compare the cost today.

Valsartan, Sacubitril
Valsartan, Sacubitril
Valsartan/Sacubitril (Generic)
Valsartan, Sacubitril
Valsartan, Sacubitril
Valsartan, Sacubitril


Medically reviewed by Dr. Samuel Maaiah, PharmD

Last updated: April 10, 2024

Dr. Maaiah is a PharmD graduate who has practiced both in pharmaceutical consulting and retail pharmacy. His interests include consulting and the development and approval of new therapeutics. He currently works as a Medical Information Consultant (MIC) and as a retail pharmacist. As a MIC he helps pharmaceutical companies with projects and by consulting as a medical information expert.

When Dr. Maaiah is not working, he enjoys spending time with his family and friends, doing outdoor activities, working out, and reading.

Order Online

How to buy Entresto online?

Entresto (Sacubitril/Valsartan) can be ordered online through CanadianPharmacyOnline.com or by calling 1-800-828-4489 and speaking to customer support. The chat feature can also be used for support. For more information please visit the “How to Order” page.

Is a prescription required?

Yes, Entresto (Sacubitril/Valsartan) is a prescription medication and can only be sold with a prescription. To process your order, you will need to submit a prescription. A valid prescription from your doctor is required. The prescription can be emailed ([email protected]), uploaded, or faxed (1-800-416-8019). Alternatively, we can reach out to your doctor to attain a valid prescription if you would like.

What is the maximum amount that can be ordered?

A 90-day supply  is the maximum amount that can be ordered at one time. The amount that can be ordered will be based on the directions and quantity indicated on the prescription from your provider. Refills are kept on file for future orders.

Is it safe to order online from Canadian Pharmacy Online?

Absolutely. All our partner pharmacies are fully licensed and certified in their respective countries. We operate just like your local pharmacy would, with our main priority being to provide you access to safe and affordable prescription medication. We ensure that your shopping experience is safe and secure with our Norton Shopping Guarantee. 

Entresto Cost

How much does Entresto (Sacubitril/Valsartan) cost?

Entresto 24mg/26 mg –  (Brand)

  • Average US retail price (60 Tablets) – $653.00
  • Our Price (56 Tablets) – $250.00

At CanadianPharmacyOnline.com, we make sure to keep drug prices low. You can view the Entresto (Sacubitril/Valsartan) cost savings above.

What is the lowest price of Entresto (Sacubitril/Valsartan) per unit?

Lowest Price Per Unit: $4.29/unit for Entresto (Sacubitril/Valsartan) 24/26 mg tablets

Is this price for Entresto (Sacubitril/Valsartan) without insurance?

The listed prices above are without insurance. Unfortunately, we are unable to accept insurance. However, we will give you an official receipt which you can use to apply for reimbursement with your insurer. We are unable to adjudicate with US insurance providers.

Why is Entresto (Sacubitril/Valsartan) cheaper from Canada than from the United States?

Drug prices in Canada and from other countries we source medication from are negotiated and regulated. The US is a free market economy which is why the price differs since pharmaceutical suppliers can charge what they consider appropriate for products. As a result, we can offer lower prices to our patients as we utilize medications from these countries. 

Entresto Coupon

Is there an Entresto (Sacubitril/Valsartan) coupon available?

Sorry, we do not have an Entresto (Sacubitril/Valsartan) coupon available at this time.

Entresto Generic

Is there a lower cost generic Entresto (Sacubitril/Valsartan) available?

Entresto (Sacubitril/Valsartan) is not available as a generic alternative. 

How much cheaper is generic Entresto (Sacubitril/Valsartan)?

There is currently no generic alternative available on the market.

What is the difference between brand and generic Entresto (Sacubitril/Valsartan)?

Once available on the market, there will be no difference between generic and brand Entresto. Generic formulations of medications contain the same active ingredients and meet the same quality, strength, and purity standards as the brand formulation. 


Is shipping available to the United States?

Yes. An email notification will be sent to you once the item has been shipped. We ship nationwide across the United States.

How much does shipping cost?

Standard Shipping is free.

Is express shipping available?

If a product of Canada is available then express shipping can be selected with an estimated delivery time of 3-5 business days. You have the option at the checkout page to select the express shipping option ($25) if available for that medication source.

Refill Rx

How to refill a prescription?

Refilling your prescription is made easy with Canadian Pharmacy Online. You can sign in to your online account and view your previous orders and see which prescriptions we have on file. Placing a refill order online is made simple by accessing the reorder section in your account. You can also call us and speak to customer support to place a refill. Our live chat is also a great place to connect with us to place a refill order while you are on the go.

Are prescriptions automatically refilled?

We do not automatically refill prescriptions as there can be cases where you are no longer taking the medication, your doctor has changed your dose, etc. However, we provide a friendly refill reminder service. We will kindly notify you by phone or email as to the best time to place a refill order based on your prescription history.

Drug Information

About Entresto (Sacubitril/Valsartan)

What is Entresto (Sacubitril/Valsartan)?

Entresto is a combination prescription medication that is classified as a neprilysin inhibitor and angiotensin II receptor blocker (ARB).


What is Entresto used for? 

Entresto (Sacubitril/Valsartan) is used to reduce the risk of cardiovascular death in patients with chronic heart failure and to help treat symptoms of heart failure.

How does it work?

It inhibits neprilysin which increases levels of natriuretic peptides and inhibits angiotensin-II dependent aldosterone release. 


How do I take Entresto (Sacubitril/Valsartan)?

You should take Entresto (Sacubitril/Valsartan) as instructed by your physician. It is important to note, your dose may need to be adjusted several times to find what works best for you.

What dosages are available?

Entresto (Sacubitril/Valsartan) is available as brand name 24mg/26mg, 49mg/51mg, and 97mg/103mg tablets

What is the recommended dosage?

Generally, it is dosed 1 tablet by mouth twice daily but take as directed by your doctor. 

What is the maximum dosage?

The maximum recommended dosage is 194/206mg/day.

What if I miss a dose?

If you miss a dose, take it as soon as you remember. If it is relatively close to when your next dose is due, wait until then and take a normal dose. Do not take an extra dose to make up for the missed dose. 


Warnings & Precautions

What should you know before you take Entresto (Sacubitril/Valsartan)?

Patients should monitor for signs and symptoms of angioedema (swelling of the tongue) as this is a potentially serious side effect of Entresto (Sacubitril/Valsartan).

Hypotension is a common side effect of Entresto (Sacubitril/Valsartan), talk with your doctor if you have significant dizziness with Entresto (Sacubitril/Valsartan). 

Patients with existing renal dysfunction or those at risk of developing it should be monitored regularly for renal injury.  

Side Effects

What are the side effects of Entresto (Sacubitril/Valsartan)?

Some common (≥5%) side effects include:

  • Hypotension
  • Hyperkalemia 
  • Cough 
  • Dizziness
  • Renal Failure 

Speak to your doctor for a full list of side effects.


Does this medication interact with other drugs, foods, or alcohol?

Patients with an eGFR <60 should avoid Entresto (Sacubitril/Valsartan) in combination with aliskiren. 

Potassium-sparing diuretics should be used with caution as they can increase a patient’s risk of developing hyperkalemia. 

Concomitant use of other agents known to cause kidney damage should be limited while on this medication. 

Patients taking lithium should be closely monitored while starting or changing dosages. 


How should this medication be stored?

Entresto (Sacubitril/Valsartan) should be stored at room temperature (68°F to 77°F). Protect Entresto (Sacubitril/Valsartan) from moisture. 

Pharmacist Tips

  • Patients transitioning from an ACEi therapy to Entresto (Sacubitril/Valsartan) should ensure that they have a 36 hour washout period before starting Entresto (Sacubitril/Valsartan). 
  • In order for this medication to reach maximum effectiveness, it will need to be titrated to a maximum tolerated dosage. 
  • Talk with your doctor if you become or are trying to become pregnant. 

The above information is an educational aid only. It is not intended as medical advice for individual conditions or treatments. Talk to your doctor, nurse or pharmacist before following any medical regimen to see if it is safe and effective for you.


Save $10 on your first order!
Enter Canadian Pharmacy Online coupon code CPO10 to save $10 off your order. Minimum $50 order value. *Coupon codes are one-time use and cannot be combined.

Entresto FAQ

Q: Can you take Entresto (Sacubitril/Valsartan) with milk?

Yes, the manufacturer has specified that food has no clinically significant effect on the absorption.

Q: What happens if you suddenly stop taking Entresto (Sacubitril/Valsartan)?

You should not discontinue this therapy unless otherwise instructed by your physician. Stopping this medication can worsen your symptoms of heart failure if you stop taking it suddenly. 

Q: Does Entresto (Sacubitril/Valsartan) strengthen your heart?

It was shown to reduce death and hospitalization in patients with heart failure. The most benefit was found in patients with an ejection fraction below normal.

Q: Does Entresto (Sacubitril/Valsartan) make you sleepy?

A frequent complaint of patients starting this medication is dizziness, this dizziness is generally temporary when starting the medication or tolerating an increase in dose. 

Q: Does Entresto (Sacubitril/Valsartan) lower heart rate?

No, Sacubitril/Valsartan functions to lower blood pressure by reducing the contraction of blood vessels in the body.

The above information is an educational aid only. It is not intended as medical advice for individual conditions or treatments. Talk to your doctor, nurse or pharmacist before following any medical regimen to see if it is safe and effective for you.