Januvia (Sitagliptin)

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Medically reviewed by Dr. Samuel Maaiah, PharmD

Last updated: February 10, 2022

Dr. Maaiah is a PharmD graduate who has practiced both in pharmaceutical consulting and retail pharmacy. His interests include consulting and the development and approval of new therapeutics. He currently works as a Medical Information Consultant (MIC) and as a retail pharmacist. As a MIC he helps pharmaceutical companies with projects and by consulting as a medical information expert.

When Dr. Maaiah is not working, he enjoys spending time with his family and friends, doing outdoor activities, working out, and reading.

Order Online

How to buy Januvia (Sitagliptin) online?

Januvia (Sitagliptin) can be ordered online through CanadianPharmacyOnline.com or by calling 1-800-828-4489 and speaking to customer support. The chat feature can also be used for support. For more information please visit the “How to Order” page.

Is a prescription required?

Yes, a valid prescription from your doctor is required. Januvia (Sitagliptin) is a prescription medication and can only be sold with a prescription. To process your order, you will need to submit a prescription. The prescription can be emailed ([email protected]), faxed (1-800-416-8019), or uploaded. Alternatively, we can reach out to your doctor to attain a valid prescription if you would like.

What is the maximum amount that can be ordered?

A 3-month supply (90 days) is the maximum amount that can be ordered at one time. Refills are kept on file for future orders. The amount that can be ordered will be based on the directions and quantity indicated on the prescription from your doctor.

Is it safe to order Januvia (Sitagliptin) from Canadian Pharmacy Online?

Absolutely. All our partner pharmacies are fully licensed and certified in their respective countries. We ensure that your shopping experience is safe and secure with our Norton Shopping Guarantee. We operate just like your local pharmacy would, with our main priority being to provide you access to safe and affordable prescription medication.

Januvia Cost

How much does Januvia (Sitagliptin) cost?

Januvia 100mg – 84 Tablets

  • Average US retail price – $1769.47
  • Our price – $150.00

Above shows the price comparison between the average U.S. retail price and Canadian Pharmacy Online of Januvia 100mg.

At CanadianPharmacyOnline.com, we make sure to keep drug prices low.

We provide Januvia (Sitagliptin) 100 mg tablets here at Canadian Pharmacy Online at discount price. A quantity of 84 tablets of Januvia (Sitagliptin) costs $150, which comes out to $1.79 per unit.

What is the lowest price of Januvia (Sitagliptin) per unit?

Lowest Price Per Unit: $1.79/unit for Januvia (Sitagliptin) 100mg tablets 

Is this price for Januvia (Sitagliptin) without insurance?

The listed prices are not through insurance. Unfortunately, we cannot accept insurance. However, we will give you an official receipt which you can use to apply for reimbursement with your insurer. We are also unable to process claims with US insurance providers.

Why is Januvia (Sitagliptin) cheaper from Canada than from the United States?

Drug prices in Canada and other parts of the world are regulated. The US is a free market economy which is why the price differs since pharmaceutical suppliers can charge what they consider appropriate for the product. As a result, we can offer lower prices to our patients as we receive medications from these countries. 

Januvia Coupon

Is there a coupon for Januvia available?

Yes, we do you have a Januvia coupon for an extra discount on your prescription. You can save $10 off your order with coupon code JANUVIA10. Apply coupon at checkout for instant savings and pay less for your prescription with a minimum $100 order.

Januvia Generic

Is there a lower cost generic Januvia (Sitagliptin) available?

Januvia (Sitagliptin) is not available as a generic alternative. 

How much cheaper is generic Januvia (Sitagliptin)?

Typically generic drugs are much cheaper than the brand version. There is currently no generic alternative to Januvia (Sitagliptin).  

What is the difference between brand and generic Januvia (Sitagliptin)?

Once available on the market, there will be no difference between generic and brand Januvia (Sitagliptin). Generic formulations of medications contain the same active ingredients and meet the same quality, strength, and purity standards as the brand formulation.


Is shipping available to the United States?

Yes. An email notification will be sent to you once the item has been shipped. We ship nationwide across the United States. 

How much does shipping cost?

There are no standard shipping fees.

Is express shipping available?

If a product of Canada is available then express shipping can be selected with an estimated delivery time of 3-5 business days. You have the option at the checkout page to select the express shipping option ($25) if available for that medication source.

Refill Rx

How to refill a prescription?

Refilling your prescription is made easy with Canadian Pharmacy Online. You can sign into your online account and view your previous orders and see which prescriptions we have on file. Placing a refill order online is made simple by accessing the reorder section in your account.

You can also call us at 1-800-828-4889 and speak to customer support to place a refill. Our live chat is also a great place to connect with us to place a refill order while you are on the go.

Are prescriptions automatically refilled?

We do not automatically refill prescriptions as there can be cases where you are no longer taking the medication, your doctor has changed your dose, etc. However, we provide a friendly refill reminder service. We will kindly notify you by phone or email as to the best time to place a refill order based on your prescription history.

Drug Information

About Januvia (Sitagliptin)

What is Januvia (Sitagliptin)?

Januvia (Sitagliptin) is a prescription medication that is classified as a dipeptidyl peptidase 4 (DPP-4) inhibitor.


What is Januvia used for? 

It is used for the treatment of type 2 diabetes mellitus (adjunct to diet and exercise) as monotherapy or combination therapy.

How does it work?

DPP4 breaks down glucagon-like peptide (GLP-1) enzymes which are effective at lowering blood glucose in a glucose-dependent manner. By this inhibition, GLP-1 levels are increased and can lower blood glucose more effectively. 


How do I take Januvia (Sitagliptin)? 

Take your Januvia (Sitagliptin) by mouth with or without food at the same time every day as directed by your doctor. 

What dosages are available?

Januvia (Sitagliptin) comes only as a brand name in a 25mg, 50mg, or 100mg tablet. 

What is the recommended dosage?

It is typically dosed 100mg once daily but take as directed by your doctor.

What is the maximum dosage?

The maximum recommended dosage is 100mg/day.

What if I miss a dose?

Take the medication as soon as possible if you have missed a dose. If it is almost time for your next dose, skip the missed dose and return back to your regular schedule. Never double the dose.

Warnings & Precautions

What should you know before you take Januvia (Sitagliptin)?

Severe/disabling arthralgia has been reported with DPP-4 inhibitors. Onset can occur within a day to years after starting therapy. 

Bullous pemphigoid development has been associated with DPP-4 inhibitors.

Hypersensitivity reactions (immediate), such as anaphylaxis and angioedema, have been reported and are not dose-related. 

Cases of acute pancreatitis, chronic pancreatitis, and pancreatic cancer have been reported with use of incretin-based therapies (e.g., DDP4 inhibitors and glucagon-like peptide 1 [GLP-1] receptor agonists).

Kidney dysfunction may require a dose adjustment

  • eGFR > 45 mL/minute/1.73m2: No dose adjustment needed. 
  • eGFR 30 to 45 mL/minute/1.73m2: 50 mg once daily
  • eGFR < 30 mL/minute/1.73m2: 25 mg once daily

Severe hepatic impairment (Child-Pugh class C) does not have any dose adjustments in the manufacturer’s labeling (has not been studied).

Treatment with a DDP-4 inhibitor has been associated with heart failure. However, a large-randomized, double-blinded study in patients with established cardiovascular disease and type 2 diabetes showed that the occurrence of the primary composite outcome (history of major CAD, atherosclerotic peripheral arterial disease, or ischemic cerebrovascular disease), the occurrence of the primary composite cardiovascular outcome (nonfatal MI, nonfatal stroke, cardiovascular death, or hospitalization for unstable angina) with sitagliptin was found to be noninferior to placebo. The rate of hospitalization for heart failure did not differ between the two groups. The American Diabetes Association (ADA) suggests that DPP-4 inhibitors (except saxagliptin) can be considered in patients with heart failure. 

Side Effects

What are the side effects of Januvia (Sitagliptin)?

Some common side effects include:

  • Nasopharyngitis

Speak to your doctor for a full list of side effects that apply to you if you are taking Januvia (Sitagliptin).


Does this medication interact with other drugs, foods, or alcohol?

Use with sulfonylureas may increase the risk of hypoglycemic effect of the sulfonylurea. A dose decrease of the sulfonylurea should be considered when starting a DPP-4 inhibitor (Risk Category D).

This is not a full list of potential drug-drug-interactions. Speak to your doctor if you have any concerns about drug-drug-interactions. 


How should this medication be stored?

Januvia (Sitagliptin) should be stored between 20-25°C (68-77°F). Excursions are allowed to be stored between 15-30C (59-86F).

Pharmacist Tips

  • It is important to check your blood sugars daily and  write the readings down. 

The above information is an educational aid only. It is not intended as medical advice for individual conditions or treatments. Talk to your doctor, nurse or pharmacist before following any medical regimen to see if it is safe and effective for you.


Januvia Coupon
Use Januvia coupon code to get $10 discount. Minimum $100 purchase required. *Coupon codes are one-time use and cannot be combined.

Januvia FAQ

Is Januvia (Sitagliptin) an insulin?

No. Januvia (Sitagliptin) is a DPP-4 inhibitor.

Are Januvia (Sitagliptin) and metformin the same?

No. Januvia (Sitagliptin) is a DDP-4 inhibitor while metformin is a biguanide.

Is Januvia (Sitagliptin) generic yet?

No. Januvia (Sitagliptin) is currently only available as a brand.

What kind of drug is Januvia (Sitagliptin)?

Januvia (Sitagliptin) is a DDP-4 inhibitor and works by prolonging active incretin levels, which regulate glucose homeostasis by increasing insulin synthesis and release from the pancreatic beta cells as well as decreased glucagon secretion from the pancreatic alpha cells.

Is Januvia (Sitagliptin) hard on the kidneys?

Januvia (Sitagliptin) can be used in patients with renal dysfunction if dosed appropriately. Acute renal failure has been reported postmarketing. 

The above information is an educational aid only. It is not intended as medical advice for individual conditions or treatments. Talk to your doctor, nurse or pharmacist before following any medical regimen to see if it is safe and effective for you.