Janumet XR (Sitagliptin/Metformin)

Rx Prescription Required

Select your dosage below to view Janumet XR cost and place your order. Save up to 90% and get FREE standard shipping on prescription medication delivered to your door.

Janumet XR 50mg/1000mg
Sitagliptin Phosphate, Metformin Hydrochloride
Merck Sharp & Dohme
Janumet XR 50mg/500mg
Sitagliptin Phosphate, Metformin Hydrochloride
Merck Sharp & Dohme
Janumet XR 100mg/1000mg
Sitagliptin Phosphate, Metformin Hydrochloride
Merck Sharp & Dohme
Janumet XR 50mg/1000mg
Sitagliptin Phosphate, Metformin Hydrochloride
Merck Sharp & Dohme
Janumet XR 100mg/1000mg
Sitagliptin Phosphate, Metformin Hydrochloride
Merck Sharp & Dohme

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Medically reviewed by Dr. Samuel Maaiah, PharmD

Last updated: February 10, 2022

Dr. Maaiah is a PharmD graduate who has practiced both in pharmaceutical consulting and retail pharmacy. His interests include consulting and the development and approval of new therapeutics. He currently works as a Medical Information Consultant (MIC) and as a retail pharmacist. As a MIC he helps pharmaceutical companies with projects and by consulting as a medical information expert.

When Dr. Maaiah is not working, he enjoys spending time with his family and friends, doing outdoor activities, working out, and reading.

Order Online

How to buy Janumet XR (sitagliptin and metformin) online?

Janumet XR can be ordered online through CanadianPharmacyOnline.com or by calling 1-800-828-4489 and speaking to customer support. The chat feature can also be used for support. For more information please visit the “How to Order” page.

Is a prescription required?

Yes, a valid prescription from your doctor is required. Janumet XR is a prescription medication and can only be sold with a prescription. To process your order, you will need to submit a prescription. The prescription can be emailed ([email protected]), faxed (1-800-416-8019), or uploaded. Alternatively, we can reach out to your doctor to attain a valid prescription if you would like.

What is the maximum amount that can be ordered?

A 3-month supply (90 days) is the maximum amount that can be ordered at one time. Refills are kept on file for future orders. The amount that can be ordered will be based on the directions and quantity indicated on the prescription from your provider.

Is it safe to order Janumet XR online from Canadian Pharmacy Online?

Absolutely. All our partner pharmacies are fully licensed and certified in their respective countries. We ensure that your shopping experience is safe and secure with our Norton Shopping Guarantee. We operate just like your local pharmacy would, with our main priority being to provide you access to safe and affordable prescription medication.

Janumet XR Cost

How much does Janumet XR cost?

Janumet XR 50mg/1000mg – 56 Tablets

  • Average US retail price – $594.44
  • Our price – $135.00

Above shows the price comparison between the average U.S. retail price and Canadian Pharmacy Online of Janumet XR 50mg/1000mg.

We provide Janumet XR 50 mg/1000 mg tablets here at Canadian Pharmacy Online at discount price. A quantity of 56 tablets costs $135.00, which comes out to $2.41 per unit.

What is the lowest price of Janumet XR per unit?

Lowest Price Per Unit: $1.79/unit for Janumet XR 50mg/1000mg tablets 

Is this price for Janumet XR without insurance?

The listed prices above are not including insurance. Unfortunately, we cannot accept insurance. However, we will give you an official receipt which you can use to apply for reimbursement with your insurer. We are also unable to process claims through US insurance providers.

Why is Janumet XR cheaper from Canada than from the United States?

Drug prices are regulated in Canada. The US is a free market economy which is why the price differs since pharmaceutical suppliers can charge what they determine to be appropriate for the product. As a result, we can offer lower prices to our patients as we supply medications from these countries.

Janumet XR Coupon

Is there a coupon for Janumet XR available?

Yes, we do you have a Janumet XR coupon for an extra discount on your prescription. You can save $10 off your order with coupon code JANUMETXR10. Apply coupon at checkout for instant savings and pay less for your prescription with a minimum $100 order.

Janumet XR Generic

Is there a lower cost generic Janumet XR available?

It is not available as a generic alternative.

How much cheaper is generic Janumet XR?

Generic drugs are typically much cheaper than the brand name option. There is currently no generic alternative to Janumet.  

What is the difference between brand and generic Janumet XR?

Once available on the market, there will be no difference between generic and brand Janumet. Generic formulations of medications contain the same active ingredients and meet the same quality, strength, and purity standards as the brand formulation.


Is shipping available to the United States?

Yes. An email notification will be sent to you once the item has been shipped. We ship nationwide across the United States. 

How much does shipping cost?

There are no standard shipping fees.

Is express shipping available?

If a product of Canada is available then express shipping can be selected with an estimated delivery time of 3-5 business days. You have the option at the checkout page to select the express shipping option ($25) if available for that medication source.

Refill Rx

How to refill a prescription?

Refilling your prescription is made easy with Canadian Pharmacy Online. You can sign into your online account and view your previous orders and see which prescriptions we have on file. Placing a refill order online is made simple by accessing the reorder section in your account.

You can also call us at 1-800-416-8019 and speak to customer support to place a refill. Our live chat is also a great place to connect with us to place a refill order while you are on the go.

Are prescriptions automatically refilled?

We do not automatically refill prescriptions as there can be cases where you are no longer taking the medication, your doctor has changed your dose, etc. However, we provide a friendly refill reminder service. We will kindly notify you by phone or email as to the best time to place a refill order based on your prescription history.

Drug Information

About Janumet XR (Sitagliptin/Metformin)

What is Janumet XR?

Janumet XR is a prescription medication that is classified as a combination product containing a dipeptidyl peptidase 4 (DPP-4) inhibitor (sitagliptin) and a biguanide (metformin).


What is Janumet XR used for? 

It is used for the treatment of type 2 diabetes mellitus.

How does it work?

The sitagliptin component lowers glucose levels in a glucose-dependent manner by inhibiting DPP4 which allows for increased levels of glucagon-like peptide-1 (GLP-1). Metformin increases glucose uptake and utilization to lower blood glucose levels.


How do I take Janumet XR?

Take your tablet whole by mouth with meals at the same time every day as directed by your doctor. Do not chew or crush the tablet. 

What dosages are available?

Janumet XR comes as a brand only in 50mg/500mg, 50mg/1000mg, and 100mg/1000mg ER tablets (sitagliptin IR/metformin ER).

What is the recommended dosage?

The dose differs based on patient-specific factors, for dosage recommendation refer to your doctor.

What is the maximum dosage?

The maximum recommended dosage is 100mg sitagliptin/2000mg metformin per day.

What if I miss a dose?

Take the medication as soon as possible if you have missed a dose. If it is almost time for your next dose, skip the missed dose and return back to your regular schedule. Never double the dose.

Warnings & Precautions

What should you know before you take Janumet XR?

Severe/disabling arthralgia has been reported with DPP-4 inhibitors. Onset can occur within a day to years after starting therapy. 

Bullous pemphigoid development has been associated with DPP-4 inhibitors.

Rare hypersensitivity reactions can occur, including Steven-Johnson syndrome.

Acute pancreatitis cases have been reported with use. 

Caution in renal function. Dose adjustment/discontinuation of therapy may be needed.

  • eGFR > 45 mL/minute/1.73m2: No dose adjustment needed. 
  • eGFR 30 to 45 mL/minute/1.73m2:
    • Initiation: Not recommended.
    • Continuation: A metformin dose reduction of 50% is needed (maximum 1 g/day) and limit the dose of sitagliptin to 50 mg once daily. 
  • eGFR < 30 mL/minute/1.73m2: Use is contraindicated. 

If acute kidney injury occurs during therapy, the patient should hold the medication due to the metformin component.

Worsening renal function has been reported with sitagliptin.

Vitamin B12 deficiency has been associated with long-term metformin use. Vitamin B12 serum concentrations should be periodically monitored with long-term therapy.

U.S. Boxed Warning: Metformin-induced lactic acidosis have been reported in postmarketing cases that have resulted in death. The risk is increased with renal dysfunction.

Side Effects

What are the side effects of Janumet XR?

Some common side effects include:

  • Abdominal pain, diarrhea, nausea
  • Headache
  • Upper respiratory tract infection

Speak to your doctor for a full list of side effects that apply to you.


Does this medication interact with other drugs, foods, or alcohol?

Avoid use with alcohol due to increased risk of lactic acidosis with metformin (Risk Category X).

This is not a full list of potential drug-drug-interactions. Speak to your doctor if you have any concerns about drug-drug-interactions. 


How should this medication be stored?

This medication should be stored between 20-25°C (68-77°F). Excursions are allowed to be stored between 15-30°C (59-86°F)

Pharmacist Tips

  • Take with food to decrease the risk of any gastrointestinal side effects due to the metformin component of the medication.
  • Do not chew or crush the tablet.

The above information is an educational aid only. It is not intended as medical advice for individual conditions or treatments. Talk to your doctor, nurse or pharmacist before following any medical regimen to see if it is safe and effective for you.


Janumet XR Coupon
Use Janumet XR coupon code to get $10 discount. Minimum $100 purchase required. *Coupon codes are one-time use and cannot be combined.

Janumet XR FAQ

Is Janumet XR the same as Metformin?

No. It is composed of sitagliptin and metformin.

How does Janumet XR work in the body?

It works by decreasing the amount of sugar your liver releases in your body and increases your body’s insulin sensitivity.

What class of drug is Janumet XR?

It is made up of two drug classes, a DDP-4 inhibitor and biguanide.

What is the difference between Janumet and Janumet XR?

Janumet contains only IR formulations of sitagliptin and metformin, while this medication contains IR sitagliptin and ER metformin.

What is Janumet XR used for?

It is used for the treatment of type 2 diabetes mellitus.

The above information is an educational aid only. It is not intended as medical advice for individual conditions or treatments. Talk to your doctor, nurse or pharmacist before following any medical regimen to see if it is safe and effective for you.