Premarin Vaginal Cream (Conjugated Estrogens)

Rx Prescription Required

Select your dosage below to view Premarin Vaginal Cream cost and place your order. Save up to 90% and get FREE standard shipping on prescription medication delivered to your door.

Premarin Vaginal Cream 0.625mg/g
Estrogens, Conjugated
Pfizer Inc
Premarin Vaginal Cream 0.625mg/g
Estrogens, Conjugated
Pfizer Inc


Medically reviewed by Dr. Samuel Maaiah, PharmD

Last updated: April 10, 2024

Dr. Maaiah is a PharmD graduate who has practiced both in pharmaceutical consulting and retail pharmacy. His interests include consulting and the development and approval of new therapeutics. He currently works as a Medical Information Consultant (MIC) and as a retail pharmacist. As a MIC he helps pharmaceutical companies with projects and by consulting as a medical information expert.

When Dr. Maaiah is not working, he enjoys spending time with his family and friends, doing outdoor activities, working out, and reading.

Order Online

How to buy Premarin vaginal cream (Estrogen) online?

Premarin vaginal cream can be ordered online through or by calling 1-800-828-4489 and speaking to customer support. The chat feature can also be used for support. For more information please visit the “How to Order” page.

Is a prescription required?

Yes, a valid prescription from your doctor is required. Premarin vaginal cream is a prescription medication and can only be sold with a prescription. To process your order, you will need to submit a prescription. The prescription can be emailed ([email protected]), faxed (1-800-416-8019), or uploaded. Alternatively, we can reach out to your doctor to attain a valid prescription if you would like.

What is the maximum amount that can be ordered?

A 3-month supply (90 days) is the maximum amount that can be ordered at one time. Refills are kept on file for future orders. The amount that can be ordered will be based on the directions and quantity indicated on the prescription from your provider.

Is it safe to order from Canadian Pharmacy Online?

Absolutely. All our partner pharmacies are fully licensed and certified in their respective countries. We ensure that your shopping experience is safe and secure with our Norton Shopping Guarantee. We operate just like your local pharmacy would, with our main priority being to provide you access to safe and affordable prescription medication.

Premarin Cream Cost

How much does Premarin vaginal cream (Estrogen) cost?

Premarin Cream 0.625 mg/g – (1 tube = 30g)

  • Average US retail price – $482.00
  • Our Price – $70.00

At, we make sure to keep drug prices low. You can view the Premarin Vaginal Cream cost savings above with the price comparison of Premarin vaginal cream between the average U.S. retail price and Canadian Pharmacy Online price.

What is the lowest price of Premarin Vaginal Cream per unit?

Lowest Price Per Unit: $1.79/unit for Premarin Vaginal 0.625 mg/g Cream

90-Day Meds is where to buy Premarin Cream cheap. 

Is this price for Premarin Vaginal Cream without insurance?

The listed prices are without insurance. Unfortunately, we are unable to process insurance claims. However, we will give you an official receipt which you can use to apply for reimbursement with your insurer. We are also unable to adjudicate with US insurance providers.

Why is Premarin Vaginal Cream cheaper from Canada than from the United States?

The prices of medications ordered from Canada, India, and Turkey are internally regulated by the respective governments. The US is a free market economy which is why the price differs since pharmaceutical suppliers can charge what they determine is appropriate for the product. As a result, we offer lower prices to our patients since we obtain medications from these countries.

Premarin Cream Coupon

Is there a coupon for Premarin Vaginal Cream available?

Yes, we do you have a Premarin Cream coupon for an extra discount on your prescription. You can save $10 off your order with coupon code PREMARINC10. Apply coupon at checkout for instant savings and pay less for your prescription with a minimum $50 order.

Premarin Cream Generic

Is there a lower cost generic Premarin Vaginal Cream available?

Premarin Vaginal Cream is not available as a generic alternative.

How much cheaper is generic Premarin Vaginal Cream?

There is currently no generic alternative to Premarin Vaginal Cream.

What is the difference between brand and generic Premarin Vaginal Cream?

Once available on the market, there will be no difference between generic and brand Premarin Vaginal Cream. Generic formulations of medications contain the same active ingredients and meet the same quality, strength, and purity standards as the brand formulation.


Is shipping available to the United States?

Yes. An email notification will be sent to you once the item has been shipped. We ship nationwide across the United States.

How much does shipping cost?

Standard shipping is free.

Is express shipping available?

If a product of Canada is available then express shipping can be selected with an estimated delivery time of 3-5 business days. You have the option at the checkout page to select the express shipping option ($25) if available for that medication source.

Refill Rx

How to refill a prescription?

Refilling your prescription is made easy with Canadian Pharmacy Online. You can sign into your online account and view your previous orders and see which prescriptions we have on file. Placing a refill order online is made simple by accessing the reorder section in your account.
You can also call us at 1-800-416-8019 and speak to customer support to place a refill. Our live chat is also a great place to connect with us to place a refill order while you are on the go.

Are prescriptions automatically refilled?

We do not automatically refill prescriptions as there can be cases where you are no longer taking the medication, your doctor has changed your dose, etc. However, we provide a friendly refill reminder service. We will kindly notify you by phone or email as to the best time to place a refill order based on your prescription history.

Drug Information

About Premarin Vaginal Cream (Conjugated Estrogens)

What is Premarin Vaginal Cream?

Premarin vaginal cream (estrogen) is a prescription medication and are classified as estrogen derivatives. 


What is Premarin used for? 

It is indicated for the treatment of vulvar and vaginal atrophy associated with menopause.

How does it work?

Through a negative feedback mechanism, it reduces the levels of luteinizing hormone (LH) and follicle stimulating hormone (FSH) in postmenopausal women. 


How do I take Premarin?

Use the applicator that is provided by the manufacturer and insert the cream deep into the vagina. The insertion should be as deep/far as possible into the vagina without causing any discomfort. The applicator is calibrated in 0.5 g increments up to 2 g. 

To clean the applicator:

  • Remove the plunger from the barrel and wash with mild soap and warm water.
  • Do not boil or use hot water.
  • Be sure to allow it to draw before putting it back together. 

What dosages are available?

Premarin vaginal cream is only available as a brand in 0.625 mg/g in a 30 g tube. 

What is the recommended dosage?

It is typically dosed 0.5 g daily but take as directed by your provider.

What is the maximum dosage?

The maximum recommended dosage is 2g/day.

What if I miss a dose?

Apply medication as soon as possible if you have missed a dose. If it is almost time for your next dose, skip the missed dose and return back to your regular schedule. Never double the doses.

Warnings & Precautions

What should you know before you take Premarin Vaginal Cream?

Anaphylaxis requiring emergency medical help has been reported within minutes to hours after taking the medication. Angioedema of the feet, hands, face, tongue, and larynx has also been reported.

Use may exacerbate endometriosis.

Use (estrogen compounds) has been associated with lipid effects (increased HDL-cholesterol and decreased LDL-cholesterol). Discontinue Premarin is pancreatitis.

Available information with use of estrogen (menopausal estrogen or estrogen/progestin) therapy and risk of ovarian cancer are inconsistent.

Use may cause retinal vascular thrombosis.

Caution in those with asthma.

Use may cause impairment in glucose tolerance. Caution in those with diabetes. 

Use caution in those with diseases that may be exacerbated by fluid retention.

Use of postmenopausal estsrogen may increase the risk of gallbladder disease requiring surgery.

Caution in those with hepatic hemangiomas.

Caution in those with migraines.

Caution in those with epilepsy.

Caution in those with porphyria.

Caution in those with systemic lupus erythematosus.

Caution in females with hereditary angioedema. 

Caution in those with hepatic dysfunction.

Use may cause an increase in thyroid-binding globulin (TBG).

U.S. Boxed Warning: 

  • Endometrial cancer
    • Increased risk in those with a uterus who uses unopposed estrogens
  • Cardiovascular disease (CVD)
    • Estrogen-alone should not be used for the prevention of CVD
    • Estrogen plus progestin should not be used for the prevention of CVD
  • Breast cancer
    • A substudy has shown an increased risk of invasive breast cancer in estrogen-plus-progestin therapy
  • Dementia
    • Estrogen-alone should not be used for the prevention of dementia
    • Estrogen plus progestin should not be used for the prevention of dementia
  • Risk vs. benefits 
    • Weight the risk vs benefits
    • Estrogens with or without progestins should be used at the lowest effective dose for the shortest duration possible for the treatment goal/risks for the individual woman


Side Effects

What are the side effects of Premarin Vaginal Cream?

Some common side effects include:

  • Vasodilation
  • Pain
  • Abdominal pain
  • Mastalgia, vaginitis 
  • Weakness, back pain

Speak to your doctor for a full list of side effects that apply to you if you are using Premarin vaginal cream


Does this medication interact with other drugs, foods, or alcohol?

Avoid use with anastrozole, dehydroepiandrosterone, hemin, indium 111, and ospemifene (Risk Category X).

This is not a full list of potential drug-drug-interactions. Speak to your doctor if you have any concerns about drug-drug-interactions. 


How should this medication be stored?

Your Premarin tablets should be stored between 20° to 25°C (68° to 77°F). Excursions are allowed to be stored between 15° to 30°C (59° to 86°F).

Pharmacist Tips

  • If you plan or become pregnant, immediately stop the Premarin therapy.

The above information is an educational aid only. It is not intended as medical advice for individual conditions or treatments. Talk to your doctor, nurse or pharmacist before following any medical regimen to see if it is safe and effective for you.


Premarin Cream Coupon
Use Premarin Cream coupon code to get $10 discount. Minimum $50 purchase required. *Coupon codes are one-time use and cannot be combined.

Premarin Cream FAQ

Is Premarin vaginal cream a steroid?

No. Premarin is an estrogen derivative.

Is Premarin vaginal cream just estrogen?

Premarin is a conjugated estrogens (estrogen derivative).

Does Premarin vaginal cream cause weight gain?

Premarin vaginal cream can cause weight changes (<1%, postmarketing, and/or case reports).

Is Premarin vaginal cream a controlled substance?


Is Premarin vaginal cream a prescription drug?


The above information is an educational aid only. It is not intended as medical advice for individual conditions or treatments. Talk to your doctor, nurse or pharmacist before following any medical regimen to see if it is safe and effective for you.