Vivelle Dot (Estradiol-17B)

Rx Prescription Required

Select your dosage below to view Vivelle Dot cost and place your order. Save up to 90% and get FREE standard shipping on prescription medication delivered to your door.

Estradiol patches (Generic)


Medically reviewed by Dr. Samuel Maaiah, PharmD

Last updated: April 10, 2024

Dr. Maaiah is a PharmD graduate who has practiced both in pharmaceutical consulting and retail pharmacy. His interests include consulting and the development and approval of new therapeutics. He currently works as a Medical Information Consultant (MIC) and as a retail pharmacist. As a MIC he helps pharmaceutical companies with projects and by consulting as a medical information expert.

When Dr. Maaiah is not working, he enjoys spending time with his family and friends, doing outdoor activities, working out, and reading.

Order Online

How to buy Vivelle-Dot (estradiol transdermal) online?

Vivelle-Dot (estradiol transdermal) can be ordered online through or by calling 1-800-828-4489 and speaking to customer support. The chat feature can also be used for support. For more information please visit the “How to Order” page.

Is a prescription required?

Yes, a valid prescription from your doctor is required. Vivelle-Dot (estradiol transdermal) is a prescription medication and can only be sold with a prescription. To process your order, you will need to submit a prescription. The prescription can be emailed ([email protected]), faxed (1-800-416-8019), or uploaded. Alternatively, we can reach out to your doctor to attain a valid prescription if you would like.

What is the maximum amount that can be ordered?

A 3-month supply (90 days) is the maximum amount that can be ordered at one time. Refills are kept on file for future orders. The amount that can be ordered will be based on the directions and quantity indicated on the prescription from your provider.

Is it safe to order from Canadian Pharmacy Online?

Absolutely. All our partner pharmacies are fully licensed and certified in their respective countries. We ensure that your shopping experience is safe and secure with our Norton Shopping Guarantee. We operate just like your local pharmacy would, with our main priority being to provide you access to safe and affordable prescription medication.

Vivelle-Dot Cost

How much does Vivelle-Dot (estradiol transdermal) cost?

Vivelle-Dot 0.05mg/day (50mcg) – Brand (8 patches) –

  • Average US retail price – $164.60
  • Our price – $55.00

Estradiol Patches 0.05mg/day (50mcg) – Generic (8 Patches)

  • Average US retail price – $122.78
  • Our price – $45.00

At, we make sure to keep drug prices low. You can view the Vivelle-Dot (estradiol transdermal) cost savings above with the price comparison of brand and generic Vivelle-Dot 0.05mg/day between the average U.S. retail price and Canadian Pharmacy Online price.


What is the lowest price of Vivelle-Dot (estradiol transdermal) per unit?

Lowest Price Per Unit: $4.13/unit for generic Vivelle-Dot (estradiol transdermal) 0.05 mg patches 

Is this price for Vivelle-Dot (estradiol transdermal) without insurance?

These prices are without insurance. Unfortunately, we are unable to accept insurance. However, we will give you an official receipt which you can use to apply for reimbursement with your insurer since we are unable to adjudicate with US insurance providers.

Why is Vivelle-Dot (estradiol transdermal) cheaper from Canada than from the United States?

Drug prices in Canada and from other countries we source medication from are negotiated and regulated. The US is a free market economy which is why the price differs since pharmaceutical suppliers can charge what they determine appropriate for the product. As a result, we can offer lower prices to our patients as we utilize medications from these countries. 

Vivelle-Dot Coupon

Is there a coupon for Vivelle Dot available?

Yes, we do you have a Vivelle Dot coupon for an extra discount on your prescription. You can save $10 off your order with coupon code VIVELLE10. Apply coupon at checkout for instant savings and pay less for your prescription with a minimum $60 order.

Vivelle-Dot Generic

Is there a lower cost generic Vivelle-Dot (estradiol transdermal) available?

Vivelle-Dot (estradiol transdermal) is available as a generic alternative. 

How much cheaper is generic Vivelle-Dot (estradiol transdermal)?

Generic Vivelle-Dot (estradiol) patches are $5 cheaper than the brand formulation.

What is the difference between brand and generic Vivelle-Dot?

There is no difference between generic and brand Vivelle-Dot. Generic formulations of medications contain the same active ingredients and meet the same quality, strength, and purity standards as the brand formulation.


Is shipping available to the United States?

Yes. An email notification will be sent to you once the item has been shipped. We ship nationwide across the United States.

How much does shipping cost?

Standard shipping is free.

Is express shipping available?

If a product of Canada is available then express shipping can be selected with an estimated delivery time of 3-5 business days. You have the option at the checkout page to select the express shipping option ($25) if available for that medication source.

Refill Rx

How to refill a prescription?

Refilling your prescription is made easy with Canadian Pharmacy Online. You can sign into your online account and view your previous orders and see which prescriptions we have on file. Placing a refill order online is made simple by accessing the reorder section in your account.

You can also call us at 1-800-416-8019 and speak to customer support to place a refill. Our live chat is also a great place to connect with us to place a refill order while you are on the go.

Are prescriptions automatically refilled?

We do not automatically refill prescriptions as there can be cases where you are no longer taking the medication, your doctor has changed your dose, etc. However, we provide a friendly refill reminder service. We will kindly notify you by phone or email as to the best time to place a refill order based on your prescription history.

Drug Information

About Vivelle Dot (Estradiol-17B)

What is Vivelle-Dot (estradiol transdermal)? 

Vivelle dot is a transdermal estrogen. 


What is it used for? 

It is used to treat vasomotor and vaginal atrophy symptoms associated with menopause. It is also used to treat hypoestogenism and used as a preventative medication for postmenopausal osteoporosis.

How does it work?

Through a negative feedback mechanism, estrogen decreases luteinizing hormone (LH) and follicle stimulating hormone (FSH) in postmenopausal women.


How do I take Vivelle-Dot (estradiol transdermal)? 

You should use as directed by your physician. Vivelle-Dot (estradiol transdermal) is generally applied to a clean and dry area of the lower abdomen or buttocks. This patch should be changed twice weekly or approximately every 3 to 4 days. 

What dosages are available?

It is available as brand 25mcg, 37.5mcg, 50mcg, 75mcg, and 100 mcg patches. It is also available as generic 50mcg, 75 mcg, and 100mcg patches.

What is the recommended dosage?

Typically a 0.0375mg patch is applied twice weekly but take as directed by your doctor.

What is the maximum dosage?

The maximum recommended dosage is 0.1mg/day.

What if I miss a dose?

If you miss applying a new patch or forget to remove an old one, apply one as soon as you remember. If it is relatively close to when your next patch would be due, wait until then and resume your normal schedule. Do not apply an extra patch to make up for the missed dose. 

Warnings & Precautions

What should you know before you take Vivelle-Dot (estradiol transdermal)?

Estrogen products increase your chance of acquiring gallbladder disease

If you experience high calcium levels, reduced vision, increased lipids, or jaundice, discontinue Vivelle-Dot (estradiol transdermal).

Patients on thyroid replacement should be monitored closely for changes.

Side Effects

What are the side effects of Vivelle-Dot (estradiol transdermal)?

Some common (≥10%) side effects include:

  • Headache
  • Breast tenderness
  • Nasopharyngitis
  • Sinusitis
  • Sinus headache
  • Upper respiratory tract infection
  • Back pain
  • Depression 
  • Irregular vaginal bleeding/spotting

Speak to your doctor for a full list of side effects.


Does this medication interact with other drugs, foods, or alcohol?

Estrogen is metabolized by CYP3A4. Medications that are inducers or inhibitors of this enzyme should be used with caution. 


How should this medication be stored?

It should be stored at room temperature. Store in the original pouch until ready to be used. 

Pharmacist Tips

  • If you are postmenopausal and experience abnormal vaginal bleeding, inform your doctor promptly. 
  • Utilizing this therapy alone, without progesterone, can put you at increased risk for developing breast/ovarian cancer. Ensure you are getting regular screenings while on this medication. 
  • When throwing the patches away it is important to fold the sticky side together so that none of the medicated side of the patch is exposed. 

The above information is an educational aid only. It is not intended as medical advice for individual conditions or treatments. Talk to your doctor, nurse or pharmacist before following any medical regimen to see if it is safe and effective for you.


Vivelle Dot Coupon
Use Vivelle coupon code to get $10 discount. Minimum $60 purchase required. *Coupon codes are one-time use and cannot be combined.

Vivelle Dot FAQ

Does Vivelle-Dot (estradiol transdermal) patch cause weight gain?

In clinical studies, this medication caused weight gain in up to 8% of individuals depending on dose. 

How often do you change Vivelle-Dot (estradiol transdermal)?

It should be changed every 3 to 4 days or twice weekly. 

Can Vivelle-Dot (estradiol transdermal) patches be cut?

No, the patches should not be cut. If you accidentally cut a patch while opening the pouch, discard the patch safely, do not use it. 

Can you wear two estrogen patches?

You should use this medication as directed by your physician. Generally only one patch at a time is recommended.

Can you swim with Vivelle patches?

Yes, showering and swimming should not cause the patch to be removed. 

The above information is an educational aid only. It is not intended as medical advice for individual conditions or treatments. Talk to your doctor, nurse or pharmacist before following any medical regimen to see if it is safe and effective for you.