Wellbutrin XL (Bupropion)

Rx Prescription Required

Living with major depressive disorder or seasonal affective disorder can be challenging. Luckily, Wellbutrin XL offers a reliable solution to treat depression in patients. We’re enhancing mental health at great prices per unit from Canadian Pharmacy Online.

Wellbutrin’s extended-release formulation provides steady relief from symptoms. It also effectively enhances energy levels and alleviates chronic fatigue associated with depression. Additionally, Wellbutrin XL is sometimes used as an adjunct therapy in smoking cessation, highlighting its versatile benefits.

As a prescription medication, Wellbutrin XL requires consultation with your healthcare provider to ensure it fits your treatment plan. When you have a prescription, create your account, load your script, and order online.

Wellbutrin XL
Bupropion Hydrochloride
Bupropion XL (Generic)
Bupropion Hydrochloride
Bupropion XL (Generic)
Bupropion Hydrochloride
Wellbutrin XL
Bupropion Hydrochloride
Bupropion XL (Generic)
Bupropion Hydrochloride


Medically reviewed by Dr. Samuel Maaiah, PharmD

Last updated: April 10, 2024

Dr. Maaiah is a PharmD graduate who has practiced both in pharmaceutical consulting and retail pharmacy. His interests include consulting and the development and approval of new therapeutics. He currently works as a Medical Information Consultant (MIC) and as a retail pharmacist. As a MIC he helps pharmaceutical companies with projects and by consulting as a medical information expert.

When Dr. Maaiah is not working, he enjoys spending time with his family and friends, doing outdoor activities, working out, and reading.

Discover the Benefits of Wellbutrin XL

Wellbutrin XL (Bupropion) is a unique antidepressant that improves mood and energy. It does so by effectively targeting norepinephrine and dopamine, rather than serotonin. This difference often results in fewer side effects related to sexual desire. Taken once daily, Wellbutrin XL ensures stable medication levels throughout the day. That's why it's a convenient and effective option for those managing depression.

Wellbutrin XL Pricing

At CanadianPharmacyOnline.com, we are committed to making mental health treatment affordable by offering Wellbutrin XL at competitive prices. While the average U.S. retail price for 90 tablets of Wellbutrin XL 150mg is $5,450.26, we provide it for just $90.00. Additionally, the generic form, Bupropion XL, is available for $50.00, significantly lower than the average U.S. retail price of $201.54. This translates to a per-unit cost as low as $0.94 for generic Bupropion 150mg tablets.

We provide detailed pricing information on our website and offer personalized assistance through our support team to help you find the best savings options.

Wellbutrin XL FAQ

How Long Does It Take for Wellbutrin XL to Start Working?

Patients may notice improvements in mood and energy within the first few weeks. Full therapeutic effects may take several weeks. Consistent daily dosing is crucial for optimal results.

Are There Any Common Side Effects Associated with Wellbutrin XL?

Common side effects include dry mouth, sweating, nausea, vomiting, constipation, and insomnia. Most side effects are mild and often diminish as your body adjusts to the medication.

Can Wellbutrin XL Be Used in Combination with Other Antidepressants?

Wellbutrin XL can sometimes be combined with other antidepressants if a single medication isn't fully effective. Always consult your doctor to ensure safe and effective medication management.

Is Wellbutrin XL Addictive?

Wellbutrin XL is not considered addictive, but it should be used only as prescribed by a healthcare professional.

Can Teenagers Take Wellbutrin XL?

While Wellbutrin XL is generally prescribed for adults, it can be prescribed to teenagers over 12 years old for depression under a doctor's supervision. Regular check-ups are recommended to ensure safe and effective treatment.

Enhance Your Mental Well-being

Take a step towards better mental health with Wellbutrin XL and enjoy significant savings. Create an account with us today, upload your prescription, and have your prescription delivered directly to your home.

Order Online

How to buy Wellbutrin XL online?

Wellbutrin XL can be ordered online through CanadianPharmacyOnline.com or by calling 1-800-828-4489 and speaking to customer support. The chat feature can also be used for support. For more information please visit the “How to Order” page.

Is a prescription required?

Yes, a valid prescription from your doctor is required. Wellbutrin XL is a prescription medication and can only be sold with a prescription. To process your order, you will need to submit a prescription. The prescription can be emailed ([email protected]), faxed (1-800-416-8019), or uploaded. Alternatively, we can reach out to your doctor to attain a valid prescription if you would like.

What is the maximum amount that can be ordered?

A 3-month supply (90 days) is the maximum amount that can be ordered at one time. Refills are kept on file for future orders. The amount that can be ordered will be based on the directions and quantity indicated on the prescription from your provider.

Is it safe to order from Canadian Pharmacy Online?

Absolutely. All our partner pharmacies are fully licensed and certified in their respective countries. We ensure that your shopping experience is safe and secure with our Norton Shopping Guarantee. We operate just like your local pharmacy would, with our main priority being to provide you access to safe and affordable prescription medication.

Wellbutrin XL Cost

How much does Wellbutrin XL cost?

Wellbutrin XL 150mg (Brand) – 90 Tablets

  • Average US retail price – $5,450.26
  • Our price – $90.00

Bupropion XL 150mg (Generic) – 90 Tablets

  • Average US retail price – $201.54
  • Our price – $50.00

At CanadianPharmacyOnline.com, we make sure to keep drug prices low. You can view the Wellbutrin XL  cost savings above with the price comparison of Wellbutrin XL 150mg between the average U.S. retail price and Canadian Pharmacy Online price.

What is the lowest price of Wellbutrin XL per unit?

Lowest Price Per Unit: $0.94/unit for generic Bupropion 150mg tablets 

This price reflects Bupropion cost without insurance.

Is this price for Wellbutrin XL without insurance?

The listed prices above are without insurance. Unfortunately, we are not able to accept insurance. However, we will give you an official receipt which you can use to apply for reimbursement with your insurer. We are  unable to adjudicate with US insurance providers.

Why is Wellbutrin XL cheaper from Canada than from the United States?

Drug prices in Canada and from other countries we source medication from are negotiated and regulated. The US is a free market economy which is why the price differs since pharmaceutical suppliers can charge what they consider appropriate for the product. As a result, we can offer lower prices to our patients as we utilize medications from these countries. 

Wellbutrin XL Coupon

Is there a coupon for Wellbutrin XL available?

Yes, we do you have a Wellbutrin XL coupon for an extra discount on your prescription. You can save $10 off your order with coupon code WELLBUTRIN10. Apply coupon at checkout for instant savings and pay less for your prescription with a minimum $50 order.

Wellbutrin XL Generic

Is there a lower cost generic Wellbutrin XL available?

Wellbutrin XL is available as a generic alternative.

How much cheaper is generic Wellbutrin XL?

Generic Wellbutrin XL is $70 cheaper than the brand formulation.

What is the difference between brand and generic Wellbutrin XL?

There is no difference between generic and brand Wellbutrin XL. Generic formulations of medications contain the same active ingredients and meet the same quality, strength, and purity standards as the brand formulation. 


Is shipping available to the United States?

Yes. An email notification will be sent to you once the item has been shipped. We ship nationwide across the United States.

How much does shipping cost?

Standard shipping is free.

Is express shipping available?

If a product of Canada is available then express shipping can be selected with an estimated delivery time of 3-5 business days. You have the option at the checkout page to select the express shipping option ($25) if available for that medication source.

Refill Rx

How to refill a prescription?

Refilling your prescription is made easy with Canadian Pharmacy Online. You can sign into your online account and view your previous orders and see which prescriptions we have on file. Placing a refill order online is made simple by accessing the reorder section in your account.

You can also call us at 1-800-416-8019 and speak to customer support to place a refill. Our live chat is also a great place to connect with us to place a refill order while you are on the go.

Are prescriptions automatically refilled?

We do not automatically refill prescriptions as there can be cases where you are no longer taking the medication, your doctor has changed your dose, etc. However, we provide a friendly refill reminder service. We will kindly notify you by phone or email as to the best time to place a refill order based on your prescription history.

Drug Information

About Wellbutrin XL (Bupropion)

What is Wellbutrin XL ? 

It is an antidepressant medication in the aminoketone class.


What is Wellbutrin XL used for?

It is used to manage major depressive disorder (MDD), seasonal annual depression (SAD), and smoking cessation.

How does it work?

It weakly inhibits the neuronal uptake of dopamine and norepinephrine. It does not inhibit monoamine oxidase or the reuptake of serotonin. 


How do I take Wellbutrin XL ? 

You should take this medication as directed by your physician. Wellbutrin XL can be taken with or without food.

What dosages are available?

It is available as brand and generic 150mg and 300mg extended release tablets. 

What is the recommended dosage?

Generally, it is taken once daily in the morning. The specific dose varies based on patient-specific factors, refer to your doctor for dosing recommendations.

What is the maximum dosage?

The maximum recommended dosage is 450mg/day.

What if I miss a dose?

If you miss a dose, wait until your next scheduled dose time and take a normal dose. Do not take an extra dose to make up for the missed dose. 

Warnings & Precautions

What should you know before you take Wellbutrin XL?

Black box warning: Post marketing reports show that patients taking Wellbutrin can experience neuropsychiatric events like mood changes, psychosis, hallucinations, aggression, suicidal ideation, and suicidal attempt. If you notice any negative changes in your mood while taking Wellbutrin you should discontinue the medication and contact your doctor. The highest at risk population is young adults. 

Wellbutrin has a dose-related seizure risk. It is important that the dose is not started too high or increased too quickly as this will increase seizure risk. 

Patients with existing hypertension or at risk for developing hypertension should exercise caution with this medication as it is prone to increasing blood pressure. 

Patients with a history of maniac episodes should be monitored frequently for emergence of a maniac episode if being treated for MDD. 

Side Effects

What are the side effects of Wellbutrin XL?

Some common (≥5%) side effects include:

  • Dry mouth
  • Nausea
  • Insomnia
  • Dizziness
  • Pharyngitis
  • Abdominal pain
  • Agitation
  • Anxiety 
  • Tremor
  • Palpitation
  • Sweating
  • Tinnitus
  • Myalgia
  • Anorexia 
  • Urinary frequency 
  • Rash 

Speak to your doctor for a full list of side effects.


Does this medication interact with other drugs, foods, or alcohol?

Wellbutrin is an inhibitor of the CYP2D6 enzyme. Medications that either induce this enzyme or are metabolized by this enzyme may have interactions. 

Medications that lower the seizure threshold. 


How should this medication be stored?

Wellbutrin should be stored at room temperature (77°F)

Pharmacist Tips

  • Do not cut, crush, or chew these tablets as this will affect the extended release mechanism of the medication.
  • This medication may take some time to work for MDD. It may take up to 4 to 6 weeks before noticing a significant effect. 
  • This medication can also be used to aid in smoking cessation.

The above information is an educational aid only. It is not intended as medical advice for individual conditions or treatments. Talk to your doctor, nurse or pharmacist before following any medical regimen to see if it is safe and effective for you.


Wellbutrin Coupon
Use Wellbutrin XL coupon code to get $10 discount. Minimum $50 purchase required. *Coupon codes are one-time use and cannot be combined.

Wellbutrin XL FAQ

Does Wellbutrin XL make anxiety worse?

If you are taking this medication for MDD with concomitant anxiety and you experience a worsening of anxiety you should contact your doctor immediately. 

Does Wellbutrin XL cause hypersexuality?

In post marketing reports, patients have reported increased libido as an adverse effect.

Does Wellbutrin XL make you lose weight?

In the clinical studies up to 19% of patients experienced weight loss (> 5 lbs) compared to 6% in placebo. 

Does Wellbutrin XL work immediately?

Generally, Wellbutrin takes 4 to 6 weeks for patients to start to notice the effects. 

Why does Wellbutrin XL smell so bad?

The manufacturer does report that the tablets may have an associated odor. 

The above information is an educational aid only. It is not intended as medical advice for individual conditions or treatments. Talk to your doctor, nurse or pharmacist before following any medical regimen to see if it is safe and effective for you.