Trintellix (Vortioxetine)

Rx Prescription Required

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Trintellix 5mg
Trintellix 10mg
Trintellix 20mg
Trintellix 5mg
Trintellix 10mg
Trintellix 20mg
Trintellix 15mg


Medically reviewed by Dr. Samuel Maaiah, PharmD

Last updated: April 10, 2024

Dr. Maaiah is a PharmD graduate who has practiced both in pharmaceutical consulting and retail pharmacy. His interests include consulting and the development and approval of new therapeutics. He currently works as a Medical Information Consultant (MIC) and as a retail pharmacist. As a MIC he helps pharmaceutical companies with projects and by consulting as a medical information expert.

When Dr. Maaiah is not working, he enjoys spending time with his family and friends, doing outdoor activities, working out, and reading.

Order Online

How to buy Trintellix (Vortioxetine) online?

Trintellix (Vortioxetine) can be ordered online through or by calling 1-800-828-4489 and speaking to customer support. The chat feature can also be used for support. For more information please visit the “How to Order” page.

Is a prescription required?

Yes, a valid prescription from your doctor is required. Trintellix (Vortioxetine) is a prescription medication and can only be sold with a prescription. To process your order, you will need to submit a prescription. The prescription can be emailed ([email protected]), faxed (1-800-416-8019), or uploaded. Alternatively, we can reach out to your doctor to attain a valid prescription if you would like.

What is the maximum amount that can be ordered?

A 3-month supply (90 days) is the maximum amount that can be ordered at one time. Refills are kept on file for future orders. The amount that can be ordered will be based on the directions and quantity indicated on the prescription from your provider.

Is it safe to order from Canadian Pharmacy Online?

Absolutely. All our partner pharmacies are fully licensed and certified in their respective countries. We ensure that your shopping experience is safe and secure with our Norton Shopping Guarantee. We operate just like your local pharmacy would, with our main priority being to provide you access to safe and affordable prescription medication.

Trintellix Cost

How much does Trintellix (Vortioxetine) cost?

Trintellix 20mg –  

  • Average US retail price (30 Tablets) – $507.59
  • Our price (84 Tablets) – $390.00

At, we make sure to keep drug prices low.

You can view the Trintellix (Vortioxetine) cost savings above with the price comparison between the average U.S. retail price and Canadian Pharmacy Online price.


What is the lowest price of Trintellix (Vortioxetine) per unit?

Lowest Price Per Unit: $4.64/unit for Trintellix (Vortioxetine) 20 mg tablets

Is this price for Trintellix (Vortioxetine) without insurance?

The listed prices are Trulicity cost without insurance. Unfortunately, we cannot accept insurance. However, we will give you an official receipt which you can use to apply for reimbursement with your insurer. We are unable to adjudicate with US insurance providers.

Why is Trintellix (Vortioxetine) cheaper from Canada than from the United States?

Drug prices in Canada and from other countries we source medication from are negotiated and regulated. The US is a free market economy which is why the price can differ since pharmaceutical suppliers can charge what they deem appropriate for the product. As a result, we can offer lower prices to our patients as we utilize medications from these countries. 

Trintellix Coupon

Is there a coupon for Trintellix (Vortioxetine) available?

Yes, we do you have a Trintellix coupon for an extra discount on your prescription. You can save $10 off your order with coupon code TRINTELLIX10. Apply coupon at checkout for instant savings and pay less for your prescription with a minimum $100 order.

Trintellix Generic

Is there a lower cost generic Trintellix (Vortioxetine) available?

Trintellix (Vortioxetine) is not available as a generic alternative.

How much cheaper is generic Trintellix (Vortioxetine)?

There is currently no generic alternative to Trintellix (Vortioxetine).

What is the difference between brand and generic Trintellix (Vortioxetine)?

Once available on the market, there will be no difference between generic and brand Trintellix (Vortioxetine). Generic formulations of medications contain the same active ingredients and meet the same quality, strength, and purity standards as the brand formulation.


Is shipping available to the United States?

Yes. An email notification will be sent to you once the item has been shipped.  We ship nationwide across the United States.

How much does shipping cost?

Standard shipping is free.

Is express shipping available?

This medication can only be shipped Express in an insulated cooler containing ice and gel packs. The estimated delivery time is 3 to 5 business days.

Refill Rx

How to refill a prescription?

Refilling your prescription is made easy with Canadian Pharmacy Online. You can sign into your online account and view your previous orders and see which prescriptions we have on file. Placing a refill order online is made simple by accessing the reorder section in your account.

You can also call us at 1-800-416-8019 and speak to customer support to place a refill. Our live chat is also a great place to connect with us to place a refill order while you are on the go.

Are prescriptions automatically refilled?

We do not automatically refill prescriptions as there can be cases where you are no longer taking the medication, your doctor has changed your dose, etc. However, we provide a friendly refill reminder service. We will kindly notify you by phone or email as to the best time to place a refill order based on your prescription history.

Drug Information

About Trintellix (Vortioxetine)

What is Trintellix (Vortioxetine)?

Trintellix (Vortioxetine)is a prescription medication that is classified as an antidepressant.


What is Trintellix (Vortioxetine)used for?

It is used for the treatment of major depressive disorder (MDD) in adults.

How does it work?

It exerts its antidepressant effects by inhibiting the reuptake of serotonin (5-HT) which enhances the serotonergic activity in the central nervous system.


How do I take Trintellix (Vortioxetine)? 

Take this medication as directed by your doctor. This medication should be taken at the same time each day with or without food. It is important to note, your dose may be changed several times before your doctor finds the best dose for you.

What dosages are available?

Trintellix (Vortioxetine) is available by brand-only 5 mg, 10 mg, and 20 mg immediate release tablets.

What is the recommended dosage?

Typically patients are initiated on 10 mg once daily but may vary based on patient-specific factors, refer to your doctor for specific dosing recommendations.

What is the maximum dosage?

The maximum recommended dosage is 20 mg/day.

What if I miss a dose?

If you miss a dose, take it as soon as you remember unless it is close to the time your next dose is due. If that is the case, then skip the missed dose and resume your normal schedule but do not take double the dose to compensate for the missed dose.

Warnings & Precautions

What should you know before you take Trintellix (Vortioxetine)?

There is a risk for serotonin syndrome when taking this drug by itself; the risk is increased if Trintellix is combined with other agents that affect serotonin levels in the body. If you experience symptoms of serotonin syndrome, immediately seek medical attention and a change in therapy is needed.

There is an increased risk of bleeding when Trintellix is combined with NSAIDs, aspirin, other drugs that affect coagulation, and other serotonergic antidepressants

Screen patients for bipolar disorder prior to use as Trintellix may activate mania/hypomania in these patients

Angle closure glaucoma has been reported in some patients while using Trintellix

With the syndrome of inappropriate antidiuretic hormone secretion (SIADH), hyponatremia may occur

Side Effects

What are the side effects of Trintellix (Vortioxetine)?

Some common side effects (≥5%) include:

  • Nausea
  • Constipation
  • Vomiting

Speak to your doctor for a full list of side effects.


Does this medication interact with other drugs, foods, or alcohol?

Reduce Trintellix dose by 50% if used with strong CYP2D6 inhibitors

Increase Trintellix dose if used with CYP inducers for longer than 14 days; the Trintellix dose should not be greater than 3 times the original dose


How should this medication be stored?

This medication should be stored at 77°F (25°C) in its original container, away from light.

Pharmacist Tips

  • Tell your doctor if you miss more than 3 consecutive doses as they may want to re-titrate the medication for you to avoid adverse effects
  • This medication may increase suicidal thoughts and behavior especially when first initiating therapy. Keep follow-up visits with your doctor so they can monitor the effects of Trintellix in you and report any new suicidal thoughts as they may wish to address this issue at your visits.
  • This medication works best if you take it every day and minimize missed doses but it still may take a couple weeks for you to start seeing the beneficial effects of this medication.>
  • This medication has the potential to interact with many medications. Alert your doctor when you start taking new prescription or non-prescription medications.

The above information is an educational aid only. It is not intended as medical advice for individual conditions or treatments. Talk to your doctor, nurse or pharmacist before following any medical regimen to see if it is safe and effective for you.


Trintellix Coupon
Use Trintellix coupon code to get $10 discount. Minimum $100 purchase required. *Coupon codes are one-time use and cannot be combined.

Trintellix FAQ

Does Trintellix make you emotional?

When first initiating therapy, this medication may cause mood changes. If you experience an increase in suicidal thoughts and behavior, call the suicide hotline and alert your doctor.

When should you take Trintellix?

Some patients report feeling energized after taking this medication and may have difficulty falling asleep. If you are experiencing this issue, try to take your dose in the morning.

Does Trintellix make you lose weight?

Some patients have reported weight loss after taking this medication but overall, antidepressants typically have an unpredictable effect on weight.

What happens if you stop Trintellix cold turkey?

Stopping this medication without physician supervision is not advised especially abruptly as it may cause withdrawal symptoms and/or an increase in depression symptoms.

How long does it take for Trintellix to show benefits?

Patients have reported improvement in symptoms in about 6 – 8 weeks. Therapy is recommended for at least 4 – 6 weeks before determining therapy failure with Trintellix.

The above information is an educational aid only. It is not intended as medical advice for individual conditions or treatments. Talk to your doctor, nurse or pharmacist before following any medical regimen to see if it is safe and effective for you.