Pristiq (Desvenlafaxine)

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Medically reviewed by Dr. Samuel Maaiah, PharmD

Last updated: February 12, 2022

Dr. Maaiah is a PharmD graduate who has practiced both in pharmaceutical consulting and retail pharmacy. His interests include consulting and the development and approval of new therapeutics. He currently works as a Medical Information Consultant (MIC) and as a retail pharmacist. As a MIC he helps pharmaceutical companies with projects and by consulting as a medical information expert.

When Dr. Maaiah is not working, he enjoys spending time with his family and friends, doing outdoor activities, working out, and reading.

Order Online

How to buy Pristiq (desvenlafaxine) online?

Pristiq (desvenlafaxine) can be ordered online through or by calling 1-800-828-4489 and speaking to customer support. The chat feature can also be used for support. For more information please visit the “How to Order” page.

Is a prescription required?

Yes, a valid prescription from your doctor is required. Pristiq (desvenlafaxine) is a prescription medication and can only be sold with a prescription. To process your order, you will need to submit a prescription. The prescription can be emailed ([email protected]), faxed (1-800-416-8019), or uploaded. Alternatively, we can reach out to your doctor to attain a valid prescription if you would like.

What is the maximum amount that can be ordered?

A 3-month supply (90 days) is the maximum amount that can be ordered at one time. Refills are kept on file for future orders. The amount that can be ordered will be based on the directions and quantity indicated on the prescription from your provider.

Is it safe to order from Canadian Pharmacy Online?

Absolutely. All our partner pharmacies are fully licensed and certified in their respective countries. We ensure that your shopping experience is safe and secure with our Norton Shopping Guarantee. We operate just like your local pharmacy would, with our main priority being to provide you access to safe and affordable prescription medication.

Pristiq Cost

How much does Pristiq (desvenlafaxine) cost?

Pristiq 50mg (Brand) –

  • Average US retail price (90 Tablets) – $1523.00
  • Our Price (84 Tablets) – $175.00

Desvenlafaxine 50mg (Generic) –

  • Average US retail price (90 Tablets) – $805.65
  • Our Price (100 Tablets) – $75.00

At, we make sure to keep drug prices low.

You can view the Pristiq (Desvenlafaxine) cost savings above with the price comparison of brand and generic Pristiq (Desvenlafaxine) between the average U.S. retail price and Canadian Pharmacy Online price.

What is the lowest price of Pristiq (Desvenlafaxine) per unit?

Lowest Price Per Unit: $0.75/unit for generic Pristiq (Desvenlafaxine) 50mg tablets

Is this price for Pristiq (Desvenlafaxine) without insurance?

The prices mentioned previously are without insurance. Unfortunately, we are not able to accept insurance. However, you will have an official receipt which you can use to apply for reimbursement with your insurer. We are unable to adjudicate with US insurance providers.

Why is Pristiq (Desvenlafaxine) cheaper from Canada than from the United States?

Drug prices in Canada and from other countries we source medication from are negotiated and regulated. The US is a free market economy which is why the price differs since pharmaceutical suppliers can charge what they consider appropriate for the product. As a result, we aim to offer lower prices to our patients as we supply medications from these countries.

Pristiq Coupon

Is there a coupon for Pristiq available?

Yes, we do you have a Pristiq coupon for an extra discount on your prescription. You can save $10 off your order with coupon code PRISTIQ10. Apply coupon at checkout for instant savings and pay less for your prescription with a minimum $100 order.

Pristiq Generic

Is there a lower cost generic Pristiq (Desvenlafaxine) available?

Pristiq (Desvenlafaxine) is available as a generic alternative.

How much cheaper is generic Pristiq (Desvenlafaxine)?

Generic Pristiq (Desvenlafaxine) is $401 cheaper than brand Pristiq at a quantity of 100 tablets. Generic drugs are often 40-60% cheaper in cost than the brand option.

What is the difference between brand and generic Pristiq (Desvenlafaxine)?

There is no difference between generic and brand Pristiq (Desvenlafaxine). Generic formulations of medications contain the same active ingredients and meet the same quality, strength, and purity standards as the brand formulation.


Is shipping available to the United States?

Yes. An email notification will be sent to you once the item has been shipped. We ship nationwide across the United States.

How much does shipping cost?

Standard shipping is free.

Is express shipping available?

If a product of Canada is available then express shipping can be selected with an estimated delivery time of 3-5 business days. You have the option at the checkout page to select the express shipping option ($25) if available for that medication source.

Refill Rx

How to refill a prescription?

Refilling your prescription is made easy with Canadian Pharmacy Online. You can sign into your online account and view your previous orders and see which prescriptions we have on file. Placing a refill order online is made simple by accessing the reorder section in your account.

You can also call us at 1-800-416-8019 and speak to customer support to place a refill. Our live chat is also a great place to connect with us to place a refill order while you are on the go.

Are prescriptions automatically refilled?

We do not automatically refill prescriptions as there can be cases where you are no longer taking the medication, your doctor has changed your dose, etc. However, we provide a friendly refill reminder service. We will kindly notify you by phone or email as to the best time to place a refill order based on your prescription history.

Drug Information

About Pristiq (Desvenlafaxine)

What is Pristiq (Desvenlafaxine)? 

Pristiq (Desvenlafaxine) is a prescription medication that is classified as serotonin/norepinephrine reuptake inhibitor (SNRI).


What is Pristiq used for? 

It is indicated for the treatment of major depressive disorder.

How does it work?

It exerts its effects by inhibiting serotonin and norepinephrine reuptake which potentiates the neurotransmitter activity in the central nervous system (CNS).


How do I take Pristiq (Desvenlafaxine)?

Take your Pristiq (Desvenlafaxine) by mouth at approximately the same time each day with or without food. Do not crush, chew, dissolve, or cut the tablet.

What dosages are available?

Pristiq (Desvenlafaxine) is available as a brand and generic extended release tablet (25mg, 50mg, 100mg).

What is the recommended dosage?

It is typically dosed 50mg once daily but take as directed by your doctor.

What is the maximum dosage?

The maximum recommended dosage is 100 mg/day.

What if I miss a dose?

Take the medication as soon as possible if you have missed a dose. If it is almost time for your next dose, skip the missed dose and return back to your regular schedule. Never double the doses.

Warnings & Precautions

What should you know before you take Pristiq (Desvenlafaxine)?

Use may increase anxiety and nervousness.

Use may impair platelet aggregation, increasing bleed risk.

Use may (low potential) impair cognitive or motor performance.

Use may cause a dose-related increase in total cholesterol, LDL, and triglycerides.

Bone fractures have been associated with antidepressant use.

Use may cause a dose-related increase in systolic and diastolic blood pressure.

Use may cause mild pupillary dilation.

Eosinophilic pneumonia and interstitial lung disease have been rarely reported with venlafaxine (parent drug of Pristiq (Desvenlafaxine)).

Serotonin-syndrome (SS) has occurred with serotonergic agents.

Use may cause an increase in heart rate or blood pressure.

Caution in those with hepatic dysfunction.

Use of SNRIs and SSRIs have been associated with SIADH development. Hyponatremia has been rarely reported with use.

Use may cause a shift to mania or hypomania in those with bipolar disorder.

Caution in those with renal dysfunction.

Caution in those with previous seizure disorders.

Do not abruptly stop Pristiq (Desvenlafaxine) due to risk of discontinuation syndrome.

U.S. Boxed Warning: Suicidal thoughts and behavior. Antidepressants increase the risk of suicidal thoughts/behavior in young adults and pediatric patients in short-term studies.

Side Effects

What are the side effects of Pristiq (Desvenlafaxine)?

Some common side effects include:

  • Dizziness, drowsiness
  • Hyperhidrosis
  • Nausea, xerostomia
  • Constipation

Speak to your doctor for a full list of side effects that apply to you if you are taking Pristiq (Desvenlafaxine).


Does this medication interact with other drugs, foods, or alcohol?

Avoid use with bromopride, dapoxetine, iobenguane radiopharmaceutical products, linezolid, methylene blue, monoamine oxidase, pimozide, rasagiline, selegiline, and urokinase (Risk Category X).

This is not a full list of potential drug-drug-interactions. Speak to your doctor if you have any concerns about drug-drug-interactions.


How should this medication be stored?

Store Pristiq (Desvenlafaxine) at room temperature between 68 and 77 degrees Fahrenheit.

Pharmacist Tips

  • It may take a few weeks for you to start feeling the effects of your medication.
  • Notify your doctor immediately if you experience new or sudden changes in mood, behavior, feelings, or thoughts.
  • Do not stop taking your Pristiq (Desvenlafaxine) even if you start to feel better.
  • It is important that you continue to take your medication daily even if you feel like it is not working at first.
  • Do not cut, chew, or dissolve the tablet.

The above information is an educational aid only. It is not intended as medical advice for individual conditions or treatments. Talk to your doctor, nurse or pharmacist before following any medical regimen to see if it is safe and effective for you.


Pristiq Coupon
Use Pristiq coupon code to get $10 discount. Minimum $100 purchase required. *Coupon codes are one-time use and cannot be combined.

Pristiq FAQ

Is Pristiq (Desvenlafaxine) an SSRI?

No. Pristiq (Desvenlafaxine) is an SNRI.

Is Pristiq (Desvenlafaxine) available as generic?

Dizziness, nausea, dry mouth, constipation, decreased appetite.

Is Pristiq (Desvenlafaxine) an antipsychotic?

No. Pristiq (Desvenlafaxine) is an SNRI.

Is Pristiq available as generic?

Yes. Pristiq is the brand version of desvenlafaxine.

What class of drug is Pristiq (Desvenlafaxine)?

Desvenlafaxine belongs to a class of drugs called SNRIs.

The above information is an educational aid only. It is not intended as medical advice for individual conditions or treatments. Talk to your doctor, nurse or pharmacist before following any medical regimen to see if it is safe and effective for you.