Simbrinza (Brimonidine/Brinzolamide)

Rx Prescription Required

Select your dosage below to view Simbrinza cost and place your order. Save up to 90% and get FREE standard shipping on prescription medication delivered to your door.

Simbrinza 1%/0.2%
Brinzolamide, Brimonidine Tartrate
Simbrinza 1%/0.2%
Brinzolamide, Brimonidine Tartrate
Simbrinza 1%/0.2%
Brinzolamide, Brimonidine Tartrate


Medically reviewed by Dr. Samuel Maaiah, PharmD

Last updated: April 10, 2024

Dr. Maaiah is a PharmD graduate who has practiced both in pharmaceutical consulting and retail pharmacy. His interests include consulting and the development and approval of new therapeutics. He currently works as a Medical Information Consultant (MIC) and as a retail pharmacist. As a MIC he helps pharmaceutical companies with projects and by consulting as a medical information expert.

When Dr. Maaiah is not working, he enjoys spending time with his family and friends, doing outdoor activities, working out, and reading.

Order Online

How to buy Simbrinza online?

Simbrinza can be ordered online through or by calling 1-800-828-4489 and speaking to customer support. The chat feature can also be used for support. For more information please visit the “How to Order” page.

Is a prescription required?

Yes, a valid prescription from your doctor is required. Simbrinza is a prescription medication and can only be sold with a prescription. To process your order, you will need to submit a prescription. The prescription can be emailed ([email protected]), faxed (1-800-416-8019), or uploaded. Alternatively, we can reach out to your doctor to attain a valid prescription if you would like.

What is the maximum amount that can be ordered?

A 3-month supply (90 days) is the maximum amount that can be ordered at one time. Refills are kept on file for future orders. The amount that can be ordered will be based on the directions and quantity indicated on the prescription from your provider.

Is it safe to order from Canadian Pharmacy Online?

Absolutely. All our partner pharmacies are fully licensed and certified in their respective countries. We ensure that your shopping experience is safe and secure with our Norton Shopping Guarantee. We operate just like your local pharmacy would, with our main priority being to provide you access to safe and affordable prescription medication.

Simbrinza Cost

How much does Simbrinza cost?

Simbrinza 1%/0.2% – 10ml

  • Average US retail price (8ml) – $217.34
  • Our price – $104.00

At, we make sure to keep drug prices low. You can view the Simbrinza cost savings below:

We provide brand Simbrinza 1%/0.2% ophthalmic suspension here at Canadian Pharmacy Online. A quantity of 1 bottle (10 mL) of Simbrinza costs $104, which comes out to $10.40 per unit.

Below shows the price comparison of brand Simbrinza at a quantity of 10 mL between the average U.S. retail price and Canadian Pharmacy Online price.

What is the lowest price of Simbrinza per unit?

Lowest Price Per Unit: $9.00/unit for brand Simbrinza 1%/0.2% ophthalmic suspension

Is this price for Simbrinza without insurance?

The prices mentioned above are not processed through insurance as we are unable to process insurance claims. However, we will give you an official receipt which you can use to apply for reimbursement with your insurer. We are also unable to adjudicate with US insurance providers.

Why is Simbrinza cheaper from Canada than from the United States?

Drug prices are negotiated and regulated in Canada. Because the US is a free market economy, the price differs since pharmaceutical suppliers can charge what they deem appropriate for the product. As a result, we can offer lower prices to our patients as we supply medications from these countries. 

Simbrinza Coupon

Is there a coupon for Simbrinza available?

Yes, we do you have a Simbrinza coupon for an extra discount on your prescription. You can save $10 off your order with coupon code SIMBRINZA10. Apply coupon at checkout for instant savings and pay less for your prescription with a minimum $100 order.

Simbrinza Generic

Is there a lower cost generic Simbrinza available?

Simbrinza is not available as a generic alternative.

How much cheaper is generic Simbrinza?

There is currently no generic alternative available.

What is the difference between brand and generic Simbrinza?

Once available on the market, there will be no difference between generic and brand product. Generic formulations of medications contain the same active ingredients and meet the same quality, strength, and purity standards as the brand formulation.


Is shipping available to the United States?

Yes. An email notification will be sent to you once the item has been shipped. We ship nationwide across the United States.

How much does shipping cost?

There are no standard shipping fees.

Is express shipping available?

If a product of Canada is available then express shipping can be selected with an estimated delivery time of 3-5 business days. You have the option at the checkout page to select the express shipping option ($25) if available for that medication source.

Refill Rx

How to refill a prescription?

Refilling your prescription is made easy with Canadian Pharmacy Online. You can sign into your online account and view your previous orders and see which prescriptions we have on file. Placing a refill order online is made simple by accessing the reorder section in your account.

You can also call us at 1-800-416-8019 and speak to customer support to place a refill. Our live chat is also a great place to connect with us to place a refill order while you are on the go.

Are prescriptions automatically refilled?

We do not automatically refill prescriptions as there can be cases where you are no longer taking the medication, your doctor has changed your dose, etc. However, we provide a friendly refill reminder service. We will kindly notify you by phone or email as to the best time to place a refill order based on your prescription history.

Drug Information

About Simbrinza (Brimonidine/Brinzolamide)

What is Simbrinza?

Simbrinza is a prescription medication that is classified as a combination product that contains a carbonic anhydrase inhibitor and an alpha-2 adrenergic receptor agonist.


What is Simbrinza used for?

It is used to reduce elevated intraocular pressure in patients diagnosed with open-angle glaucoma and/or ocular hypertension.

How does it work? 

Brinzolamide is the carbonic anhydrase inhibitor that decreases aqueous humor secretion by slowing down the formation of bicarbonate ions. Brimonidine reduces the production of aqueous humor and increases uveoscleral outflow. The combination of these products together decrease intraocular pressure.


How do I take Simbrinza? 

Take this medication as directed by your doctor. Wash your hands before and after use and make sure not to touch the tip of the dropper to your eye. Shake the bottle well before each use to ensure the medication is properly suspended prior to administration. If you wear contact lenses, remove prior to administration and wait at least 15 minutes before reinserting. If you are taking other eye drops, wait at least 5 minutes until administering.

What dosages are available?

It is available as a brand 1%/0.2% ophthalmic suspension.

What is the recommended dosage?

Typically one drop is instilled into each affected eye(s) three times daily but take as directed by your doctor.

What is the maximum dosage?

The maximum recommended dosage is 3 drops into the affected eye(s) per day.

What if I miss a dose?

If you miss a dose of this medication, take your dose as soon as you remember unless it is time for your next scheduled dose. In that case, just take your scheduled dose and skip your missed dose but do not double your dose to compensate.

Warnings & Precautions

What should you know before you take Simbrinza?

There is a risk of corneal endothelium cell loss

It is not recommended in patients with a CrCl <30 mL/min (severe renal impairment) due to the lack of efficacy and safety data available in these patients
Because brinzolamide is a sulfonamide, Simbrinza may cause sulfonamide hypersensitivity reactions which can lead to serious complications such as Stevens-Johnson syndrome. Discontinue if a serious reaction occurs.
Bacterial keratitis may occur secondary to accidental contamination of multiple-dose ophthalmic solutions

Side Effects

What are the side effects of Simbrinza?

Some common side effects (≥ 3 – 5%) include:

  • Blurred vision
  • Eye irritation
  • Dysgeusia (bad taste)
  • Dry mouth
  • Eye allergy

Speak to your doctor for a full list of side effects.


Does this medication interact with other drugs, foods, or alcohol?

Known drug interactions with Simbrinza include medications in the following classes: central nervous system depressants, tricyclic antidepressants, monoamine oxidase inhibitors, antihypertensives, oral carbonic anhydrase inhibitors, and high-dose salicylate therapy.


How should this medication be stored?

Keep Simbrinza in the original container and store it in a dry place at room temperature 2 – 25°C (36 – 77°F).

Pharmacist Tips

  • Contact lenses should be removed prior to Simbrinza administration. 15 minutes post Simbrinza administration, you may reinsert lenses.
  • Make sure to keep the cap closed when not using Simbrinza and to avoid touching the tipper to the surface of the eye to prevent bacteria from entering the prescription bottle.
  • Simbrinza may cause fatigue and/or drowsiness, you should avoid hazardous activities such as driving until you know how Simbrinza will affect you.
  • Do not use past the expiration date printed on the bottle.

The above information is an educational aid only. It is not intended as medical advice for individual conditions or treatments. Talk to your doctor, nurse or pharmacist before following any medical regimen to see if it is safe and effective for you.


Simbrinza Coupon
Use Simbrinza coupon code to get $10 discount. Minimum $100 purchase required. *Coupon codes are one-time use and cannot be combined.

Simbrinza FAQ

What signs should I look out for when taking Simbrinza?

When taking Simbrinza, you should look out for any signs of allergic reactions such as rashes, wheezing, tightness in chest, difficulty breathing, or face swelling.

What should I do if I miss my dose of Simbrinza?

Use Simbrinza as soon as you remember you missed a dose. If it is almost time for your next dose, only take one dose. It is important to not take two doses of Simbrinza at the same time.

Can I wear contact lenses while taking Simbrinza?

Contact lenses should be removed prior to SImbrinza administration. You may reinsert your contact lens after 15 minutes.

Does Simbrinza cause low blood pressure?

Simbrinza contains brimonidine which may lower blood pressure. In studies, this medication had less than a 5% mean decrease in blood pressure 2 hours after administration. Exercise caution if you are taking any antihypertensives or cardiac glycosides.

Is it possible to lose hair when on Simbrinza?

Hair loss is not a reported side effect.

The above information is an educational aid only. It is not intended as medical advice for individual conditions or treatments. Talk to your doctor, nurse or pharmacist before following any medical regimen to see if it is safe and effective for you.