Glumetza (Metformin Hydrochloride)

Rx Prescription Required

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Metformin Hydrochloride
Metformin Hydrochloride (Generic)
Metformin Hydrochloride


Medically reviewed by Dr. Samuel Maaiah, PharmD

Last updated: April 10, 2024

Dr. Maaiah is a PharmD graduate who has practiced both in pharmaceutical consulting and retail pharmacy. His interests include consulting and the development and approval of new therapeutics. He currently works as a Medical Information Consultant (MIC) and as a retail pharmacist. As a MIC he helps pharmaceutical companies with projects and by consulting as a medical information expert.

When Dr. Maaiah is not working, he enjoys spending time with his family and friends, doing outdoor activities, working out, and reading.

Order Online

How to buy Glumetza (Metformin) online?

To order Glumetza , call 1-800-828-4489 and speak to customer support or order online through Use the chat feature for customer support. Visit the “How to Order” page for more information.

Is a prescription required?

Yes, a valid prescription from your doctor is required to obtain Glumetza. Glumetza (Metformin) can only be sold with a prescription since it is a prescription medication. You will need to provide a prescription to process your order. The prescription can be faxed (1-800-416-8019), [email protected], or uploaded . Alternatively, we can reach out to your doctor to obtain a valid prescription if you would like.

What is the maximum amount that can be ordered?

A 90-day supply is the maximum amount that can be ordered at one time. Refills are kept on file for future orders. The amount that can be ordered is based on the directions and authorized quantity indicated on the prescription from your provider.

Is it safe to order Glumetza (Metformin) from Canadian Pharmacy Online?

Absolutely. We operate just like your local pharmacy would, with our main priority being to provide you access to safe and affordable prescription medications. Each of our partner pharmacies are fully licensed and certified in their respective countries. We ensure that your shopping experience is safe and secure with our Norton Shopping Guarantee.

Glumetza Cost

How much does Glumetza (Metformin) cost?

At, we make sure to keep drug prices low. You can view the Glumetza (Metformin) cost savings below:

Glumetza 1000mg (Brand) –

  • Average US retail price (100 Tablets) – $6,177.60
  • Our price (180 Tablets) – $382.00

Metformin ER 1000mg (Generic) –

  • Average US retail price – N/A
  • Our Price (200 Tablets) – $280.00

We provide brand and generic Glumetza (Metformin) 1000 mg tablets here at Canadian Pharmacy Online. A quantity of 180 tablets of brand Glumetza (Metformin) costs $382, which comes out to $2.12 per unit. A quantity of 200 tablets of generic Glumetza (Metformin) costs $280, which comes out to $1.40 per unit.

Below shows the price comparison of brand and generic Glumetza (Metformin) 1000 mg tablets at a quantity of 180 and 200 tablets between the average U.S. retail price and Canadian Pharmacy Online price.

What is the lowest price of Glumetza (Metformin) per unit?

Lowest Price Per Unit: $1.40/unit for generic Glumetza (Metformin) 1000 mg tablets

Is this price for Glumetza (Metformin) without insurance?

The listed prices are without insurance. Unfortunately, we cannot accept insurance. However, we will give you an official, itemized receipt which you can use to apply for reimbursement with your insurance provider. We are also unable to adjudicate with US insurance providers.

Why is Glumetza (Metformin) cheaper from Canada than from the United States?

Drug prices are negotiated and regulated in Canada. Because the US is a free market economy, the price differs since pharmaceutical suppliers can charge what they deem appropriate for the product. As a result, we can offer lower prices to our patients as we supply medications from these countries. 

Glumetza Coupon

Is there an Glumetza coupon available?

Sorry, we do not have an Glumetza coupon available at this time.

Glumetza Generic

Is there a lower cost generic Glumetza (Metformin) available?

Glumetza (Metformin) is available as a generic alternative.

How much cheaper is generic Glumetza?

Generic Glumetza (Metformin) is $102 cheaper than brand Glumetza at a quantity of 200 tablets versus 180 tablets of brand Glumetza.

What is the difference between brand and generic Glumetza?

There is no difference between generic and brand Glumetza. Generic formulations of medications contain the same active ingredients and meet the same quality, strength, and purity standards as the brand formulation.


Is shipping available to the United States?

Yes. An email notification will be sent to you once the item has been shipped. We ship nationwide across the United States.

How much does shipping cost?

There are no standard shipping fees.

Is express shipping available?

If a product of Canada is available then express shipping can be selected with an estimated delivery time of 3-5 business days. You have the option at the checkout page to select the express shipping option ($25) if available for that medication source.

Refill Rx

How to refill a prescription?

Refilling your prescription is simple with Canadian Pharmacy Online. To see which prescriptions we have on file, sign into your account and view your previous orders. Placing a refill order online is made easy by accessing the reorder section in your account. The live chat is also a great place to connect with us to place a refill order while you are on the go. You can also call us and speak to customer support to place a refill.

Are prescriptions automatically refilled?

Prescriptions are not automatically refilled since there can be cases where you are no longer taking the medication, your doctor has changed your dose, etc. However, we provide a friendly refill reminder service. We will kindly notify you by phone or email when it is time to place a refill order based on your prescription fill history.

Drug Information

About Glumetza (Metformin Hydrochloride)

What is Glumetza?

Glumetza (Metformin) is a prescription medication that is classified as a biguanide antidiabetic medication


What is Glumetza (Metformin) used for?

It is used to achieve glycemic control in patients diagnosed with type 2 diabetes mellitus in combination with diet and exercise.

How does it work? 

It increases glucose uptake and utilization but does not affect insulin secretion. It achieves glycemic control by decreasing hepatic glucose production, decreasing intestinal absorption of glucose, and improving insulin sensitivity.


How do I take Glumetza?

Glumetza (Metformin) should be taken as directed by your doctor. It should be taken with a meal as this can lessen the chance of upset stomach and/or diarrhea. This is an extended-release formulation and should only be taken once daily, do not take more than recommended of this medication. While taking this medication, check your blood sugar as directed by your doctor.

What dosages are available?

Glumetza (Metformin) is available as brand and generic 500 mg and 1000 mg tablets.

What is the recommended dosage?

The recommended dose varies based on patient-specific factors and based on your current diabetes management plan. Refer to your doctor for specific dosing recommendations.

What is the maximum dosage?

The maximum recommended dosage is 2,000 mg/day.

What if I miss a dose?

Take the missed dose as soon as you remember unless it is close to the time you are due for your next dose. If that is the case, just wait until it is time for your next dose. Do not double your dose to compensate for your missed dose.

Warnings & Precautions

What should you know before you take Glumetza?

Black Box Warning: Lactic Acidosis resulting in death, hypothermia, hypotension, and resistant bradyarrhythmias have been reported. Symptoms of lactic acidosis include: malaise, myalgias, respiratory distress, somnolence, and abdominal pain. If you experience any of these symptoms, immediately discontinue and seek medical attention.

Chronic metformin use may lead to Vitamin-B12 deficiencies and supplementation may be required.

Hematological parameters and Vitamin-B12 levels may need to be monitored periodically

Potential for hypoglycemia when used with insulin

Side Effects

What are the side effects of Glumetza?

Some common side effects (>5%) include:

  • Hypoglycemia
  • Diarrhea
  • Nausea

Speak to your doctor for a full list of side effects.


Does this medication interact with other drugs, foods, or alcohol?

When used concomitantly with carbonic anhydrase inhibitors, the risk for lactic acidosis is increased and more frequent monitoring is recommended.

Ranolazine, vandetanib, dolutegravir, cimetidine, and other medications that can reduce metformin clearance can cause metformin accumulation in the body. Concomitant use should be used with caution and avoided if possible.

Excessive alcohol intake should be avoided as it causes increased lactate metabolism via metformin.


How should this medication be stored?

Keep Glumetza (Metformin) in the original container and store it in a dry place at room temperature 15-30°C (59-86°F).

Pharmacist Tips

  • Taking this medication with food or directly after a meal significantly reduces the chance of upset stomach or diarrhea when taking this medication. This medication is the extended-release formulation so diarrhea should be minimized but taking with food can also help reduce the chance of experiencing diarrhea.
  • Glumetza may result in ovulation in female patients. Make sure you are using appropriate contraceptive methods while taking this medication to avoid pregnancy.
  • Hypoglycemia is an uncommon side effect when taking metformin monotherapy but when combined with other diabetes medications such as insulin, the risk is increased. Symptoms of hypoglycemia include: nausea, dizziness, confusion, alterations in mental status.
  • You are at an increased risk of lactic acidosis if you are dehydrated, have excessive alcohol intake, have renal impairment, and are of older age (older than 65 years of age).

The above information is an educational aid only. It is not intended as medical advice for individual conditions or treatments. Talk to your doctor, nurse or pharmacist before following any medical regimen to see if it is safe and effective for you.


Save $10 on your first order!
Enter Canadian Pharmacy Online coupon code CPO10 to save $10 off your order. Minimum $50 order value. *Coupon codes are one-time use and cannot be combined.

Glumetza FAQ

What is the best time to take Glumetza?

It is recommended to take your dose in the evening immediately after dinner.

Does Glumetza cause stomach upset?

The extended-release formulation makes it less likely but it can still occur. Take with food to lessen the chance of stomach upset.

Does Glumetza help you lose weight?

Some patients have reported weight loss while using this medication. It is hypothesized this occurs because Glumetza changes the way your body uses and stores fat. Weight loss can be observed when combining Glumetza with adequate diet and exercise.

What is the safest drug for type 2 diabetes?

Glumetza (Metformin) is a safe and effective anti-diabetic medication.

Does Glumetza cause hair loss?

Hair loss is not a reported side effect of Glumetza.

The above information is an educational aid only. It is not intended as medical advice for individual conditions or treatments. Talk to your doctor, nurse or pharmacist before following any medical regimen to see if it is safe and effective for you.