Linzess (Linaclotide)

Rx Prescription Required

Linzess is prescribed to patients who suffer from irritable bowel syndrome (IBS). It also works to manage chronic constipation symptoms that some deal with when they have IBS. Linzess comes in a capsule form that patients take twice each day.

The cost of medications continues to climb. Many people struggle with deciding whether to fill their prescriptions because of their staggering costs. You shouldn’t have to compromise your health because of how much your medication costs.

Keep in mind that Canadian Pharmacy Online doesn’t accept health insurance policies from other countries. However, you can turn in your receipt to your insurance company and they may reimburse you

Linzess 290mcg
Allergan Inc.
Linzess 72mcg
Allergan Inc.
Linzess 145mcg
Allergan Inc.
Linzess 290mcg
Allergan Inc.


Medically reviewed by Dr. Samuel Maaiah, PharmD

Last updated: April 10, 2024

Dr. Maaiah is a PharmD graduate who has practiced both in pharmaceutical consulting and retail pharmacy. His interests include consulting and the development and approval of new therapeutics. He currently works as a Medical Information Consultant (MIC) and as a retail pharmacist. As a MIC he helps pharmaceutical companies with projects and by consulting as a medical information expert.

When Dr. Maaiah is not working, he enjoys spending time with his family and friends, doing outdoor activities, working out, and reading.

What Is Linzess?

Linzess is prescribed to patients who are dealing with irritable bowel syndrome (IBS). It helps manage chronic constipation that some patients deal with when they have IBS. 

Linzess functions by increasing your intestinal fluid. The medication speeds up how quickly your food moves through your gut and bowel tract. 

This medication can lessen some other symptoms associated with IBS. This can include abdominal discomfort, pain, bloating, and sensations of incomplete bowel movements. 

Patients who use a feeding tube or have difficulty swallowing can take Linzess. Don't crush or chew the capsule - make sure you swallow it whole. That's because the medication is found on the surface of the beads inside the medication. 

How Much Does Linzess Cost?

The cost of getting this medication can be quite steep, especially since there isn't a lower-cost generic option available. Most people pay around $552.61 when filling their prescriptions at a pharmacy in the United States. Our customers pay about $160.00 for their Linzess prescription when they order with Canadian Pharmacy Online. 

Linzess Coupons

We're happy to offer our customers a Linzess coupon they can apply to their online orders. Enter the code LINZESS10 when you're checking out to save $10 on your order. While this coupon can be applied to any dosage, you need to spend at least $100 to use it. 

Frequently Asked Questions

When Should I Take Linzess?

Many healthcare providers recommend taking Linzess on an empty stomach at least 30 minutes before you eat a meal. The great thing about Linzess is you only need to take it once a day at the same time each day.

How Long Does It Take To Go Into Effect?

Many patients notice changes in their constipation levels around seven days after they start taking Linzess. Those dealing with IBS-C reported feeling relief from their bloating, discomfort, and stomach pain within a week. Taking Linzess each day will continue to improve your stomach-related issues over time. 

It starts to work through your intestines to help with your pain and constipation. It doesn't get absorbed into your system like other medications can. Linzess can begin to get broken down by your intestines around 60 minutes after taking your dose. 

Get Started on Your Prescription Order With Canadian Pharmacy Online

You can order your Linzess prescription via our online chat function, over the phone, or through our website. Our staff is available to give you additional Linzess information or to assist you with uploading your prescription. Explore our available coupons and start saving money on your prescription today. 

[Get Started]

Order Online

How to buy Linzess online?

Linzess (Linaclotide) can be ordered online through or by calling 1-800-828-4489 and speaking to customer support. The chat feature can also be used for support. For more information please visit the “How to Order” page.

Is a prescription required?

Yes, a valid prescription from your doctor is required. Linzess (Linaclotide) is a prescription medication and can only be sold with a prescription. To process your order, you will need to submit a prescription. The prescription can be emailed ([email protected]), faxed (1-800-416-8019), or uploaded. Alternatively, we can reach out to your doctor to attain a valid prescription if you would like.

What is the maximum amount that can be ordered?

A 3-month supply (90-days) is the maximum amount that can be ordered at one time. Refills are kept on file for future orders. The amount that can be ordered will be based on the directions and quantity indicated on the prescription from your doctor.

Is it safe to order Linzess (Linaclotide) from Canadian Pharmacy Online?

Absolutely. All our partner pharmacies are fully licensed and certified in their respective countries. We ensure that your shopping experience is safe and secure with our Norton Shopping Guarantee. We operate just like your local pharmacy would, with our main priority being to provide you access to safe and affordable prescription medication.

Linzess Cost

How much does Linzess cost?

Linzess 145 mcg – 30 Capsules

  • Average US retail price – $552.61
  • Our Price – $160.00

At, we make sure to keep drug prices low.

You can view the Linzess (Linaclotide) cost savings above with the price comparison of brand Linzess capsules between the average U.S. retail price and Canadian Pharmacy Online price.

What is the lowest price of Linzess (Linaclotide) per unit?

Lowest Price Per Unit: $4.50/unit for Linzess (Linaclotide) 145mcg tablets 

Is this price for Linzess (Linaclotide) without insurance?

These prices above are Linzess cost without insurance. Unfortunately, we cannot accept insurance. However, we will give you an official receipt which you can use to apply for reimbursement with your insurance company. We are also unable to adjudicate with US insurance providers.

Why is Linzess cheaper from Canada than from the United States?

Drug prices in Canada and some other countries are negotiated and regulated.The US is a free market economy which is how the price differs since pharmaceutical suppliers can charge what they deem appropriate for the product. As a result, we offer lower prices to our patients as we utilize medications from these countries. 

Linzess Coupon

Is there a coupon for Linzess available?

Yes, we do you have a Linzess coupon for an extra discount on your prescription. You can save $10 off your order with coupon code LINZESS10. Apply coupon at checkout for instant savings and pay less for your prescription with a minimum $100 order. This online coupon can be applied to any dosage.

Linzess Generic

Is there a lower cost generic Linzess (Linaclotide) available?

Linaclotide is not available as a generic alternative.

How much cheaper is generic Linzess (Linaclotide)?

There is currently no generic alternative.  Typically generic drugs are often much cheaper than the brand option.

What is the difference between brand and generic Linzess (Linaclotide)?

Once available on the market, there will be no difference between generic and brand Linzess. Generic formulations of medications contain the same active ingredients and meet the same quality, strength, and purity standards as the brand formulation. 


Is shipping available to the United States?

Yes. An email notification will be sent to you once the item has been shipped. We ship nationwide across the United States.

How much does shipping cost?

Standard shipping is free.

Is express shipping available?

If a product of Canada is available then express shipping can be selected with an estimated delivery time of 3-5 business days. You have the option at the checkout page to select the express shipping option ($25) if available for that medication source.

Refill Rx

How to refill a prescription?

Refilling your prescription is made easy with Canadian Pharmacy Online. You can sign into your online account and view your previous orders and see which prescriptions we have on file. Placing a refill order online is made simple by accessing the reorder section in your account.

You can also call us at 1-800-828-4889 and speak to customer support to place a refill. Our live chat is also a great place to connect with us to place a refill order while you are on the go.

Are prescriptions automatically refilled?

We do not automatically refill prescriptions as there can be cases where you are no longer taking the medication, your doctor has changed your dose, etc. However, we provide a friendly refill reminder service. We will kindly notify you by phone or email as to the best time to place a refill order based on your prescription history.

Drug Information

About Linzess (Linaclotide)

What is Linzess (Linaclotide)?

Linzess (Linaclotide) is a prescription medication that is classified as a guanylate cyclase-C (GC-C) agonist. 


What is Linzess used for?

It is indicated for the treatment of chronic idiopathic constipation (CIC) and irritable bowel syndrome with constipation (IBS-C) in adults.

How does it work?

By binding to the GC-C receptor, levels of (cyclic guanosine monophosphate) cGMP are increased which stimulates the secretion of chloride and bicarbonate into the intestinal lumen. This causes an increase in intestinal fluid and results in faster transit. 


How do I take Linzess? 

Take Linaclotide capsule whole by mouth 30 minutes before your first meal of the day on an empty stomach. Loose stools or increased stool frequency may occur after taking your Linzess. Do not chew, break, or crush capsule or capsule contents.

For those with swallowing difficulties, the capsule can be opened and the contents can be put into apple sauce or water, and swallowed or given via nasogastric or gastric feeding tube.

What dosages are available?

Linaclotide is only available as a brand capsule (145mcg, 290mcg).

What is the recommended dosage?

It is typically dosed 75mcg once daily but take as directed by your doctor.

What is the maximum dosage?

The maximum recommended dosage is 290mcg/day.

What if I miss a dose?

Take the medication as soon as possible if you have missed a dose. If it is almost time for your next dose, skip the missed dose and return back to your regular schedule. Never double the doses.

Warnings & Precautions

What should you know before you take Linzess (Linaclotide)?

Lialda may cause severe diarrhea.

Side Effects

What are the side effects of Linzess (Linaclotide)?

Some common side effects include:

  • Diarrhea
  • Headache 
  • Abdominal pain, flatulence
  • Upper respiratory tract infection  

Speak to your doctor for a full list of side effects that apply to you if you are taking Linzess.


Does this medication interact with other drugs, foods, or alcohol?

There are no known significant drug-drug interactions.


How should this medication be stored?

Linzess (Linaclotide) should be stored between 68°F to 77°F (20°C to 25°C).  Store your Linezz in a dry area.

Pharmacist Tips

  • Take your Linzess (Linaclotide) 30 minutes before your first meal of the day on an empty stomach. Do not chew or crush the capsule or the capsule contents. 

The above information is an educational aid only. It is not intended as medical advice for individual conditions or treatments. Talk to your doctor, nurse or pharmacist before following any medical regimen to see if it is safe and effective for you.


Linzess Coupon
Use Linzess coupon code to get $10 discount. Minimum $100 purchase required. *Coupon codes are one-time use and cannot be combined.

Linzess FAQ

Is Linzess (Linaclotide) a laxative?

No. Linzess (Linaclotide) is GC-C agonist. It can cause diarrhea.

What class of drug is Linzess?

Linaclotide is a GC-C agonist.

Does Linzess (Linaclotide) cause gas?

Yes. Flatulence is a listed side effect.

Does Linzess (Linaclotide) cause diarrhea?

Yes. Diarrhea is a listed side effect of Linaclotide and a common side effect. 

Is Linzess (Linaclotide) over the counter?

No. Linaclotide is only available with a prescription from your doctor.

The above information is an educational aid only. It is not intended as medical advice for individual conditions or treatments. Talk to your doctor, nurse or pharmacist before following any medical regimen to see if it is safe and effective for you.