Xifaxan (Rifaximin)

Rx Prescription Required

Select your dosage below to view Xifaxan cost and place your order. Save up to 90% and get FREE standard shipping on prescription medication delivered to your door.

Rifaximin (Generic)
Rifaximin (Generic)


Medically reviewed by Dr. Samuel Maaiah, PharmD

Last updated: April 10, 2024

Dr. Maaiah is a PharmD graduate who has practiced both in pharmaceutical consulting and retail pharmacy. His interests include consulting and the development and approval of new therapeutics. He currently works as a Medical Information Consultant (MIC) and as a retail pharmacist. As a MIC he helps pharmaceutical companies with projects and by consulting as a medical information expert.

When Dr. Maaiah is not working, he enjoys spending time with his family and friends, doing outdoor activities, working out, and reading.

Order Online

How to buy Xifaxan (Rifaximin) online?

Xifaxan (Rifaximin) can be ordered online through CanadianPharmacyOnline.com or by calling 1-800-828-4489 and speaking to customer support. The chat feature can also be used for support. For more information please visit the “How to Order” page.

Is a prescription required?

Yes, a valid prescription from your doctor is required. Xifaxan (Rifaximin) is a prescription medication and can only be sold with a prescription. To process your order, you will need to submit a prescription. The prescription can be emailed ([email protected]), faxed (1-800-416-8019), or uploaded. Alternatively, we can reach out to your doctor to attain a valid prescription if you would like.

What is the maximum amount that can be ordered?

A 3-month supply (90 days) is the maximum amount that can be ordered at one time. Refills are kept on file for future orders. The amount that can be ordered will be based on the directions and quantity indicated on the prescription from your provider.

Is it safe to order from Canadian Pharmacy Online?

Absolutely. All our partner pharmacies are fully licensed and certified in their respective countries. We ensure that your shopping experience is safe and secure with our Norton Shopping Guarantee. We operate just like your local pharmacy would, with our main priority being to provide you access to safe and affordable prescription medication.

Xifaxan Cost

How much does Xifaxan (Rifaximin) cost?

Xifaxan 550mg

  • Average US retail price (42 Tablets)- $2,317.01
  • Our Price (56 Tablets) – $985.00

At CanadianPharmacyOnline.com, we make sure to keep drug prices low. You can view the Xifaxan cost savings below:

We provide Xifaxan 550mg tablets here at Canadian Pharmacy Online. A quantity of 56 tablets of Xifaxan 550mg costs $985, which comes out to $17.59 per unit.

Below shows the price comparison of Xifaxan 550mg tablets at a quantity of 56 and 42 tablets between the average U.S. retail price and Canadian Pharmacy Online price.

What is the lowest price of Xifaxan per unit?

Lowest Price Per Unit: $11.83/unit for Xifaxan 550mg tablets

Is this price for Xifaxan (Rifaximin) without insurance?

The listed prices above are not including insurance. Unfortunately, we are not able to accept insurance. However, we will give you an official receipt which you can use to apply for reimbursement with your insurer since we are unable to adjudicate with US insurance providers.

Why is Xifaxan (Rifaximin) cheaper from Canada than from the United States?

The listed prices are without insurance. Unfortunately, we cannot accept insurance. However, we will give you an official receipt which you can use to apply for reimbursement with your insurer. We are also unable to adjudicate with US insurance providers.

Xifaxan Coupon

Is there a coupon for Xifaxan available?

Yes, we do you have a Xifaxan coupon for an extra discount on your prescription. You can save $10 off your order with coupon code XIFAXAN10. Apply coupon at checkout for instant savings and pay less for your prescription with a minimum $100 order.

Xifaxan Generic

Is there a lower cost generic Xifaxan (Rifaximin) available?

Xifaxan is not available as a generic alternative in the United States. There are generic alternatives available in other countries.

How much cheaper is generic Xifaxan (Rifaximin)?

Typically generic drugs are 40-60% cheaper than the brand option.

What is the difference between brand and generic Xifaxan (Rifaximin)?

Generic formulations of medications contain the same active ingredients and meet the same quality, strength, and purity standards as the brand formulation.


Is shipping available to the United States?

Yes. An email notification will be sent to you once the item has been shipped. We ship nationwide across the United States.

How much does shipping cost?

There are no standard shipping fees.

Is express shipping available?

If a product of Canada is available then express shipping can be selected with an estimated delivery time of 3-5 business days. You have the option at the checkout page to select the express shipping option ($25) if available for that medication source.

Refill Rx

How to refill a prescription?

Refilling your prescription is made easy with Canadian Pharmacy Online. You can sign into your online account and view your previous orders and see which prescriptions we have on file. Placing a refill order online is made simple by accessing the reorder section in your account.

You can also call us at 1-800-416-8019 and speak to customer support to place a refill. Our live chat is also a great place to connect with us to place a refill order while you are on the go.

Are prescriptions automatically refilled?

We do not automatically refill prescriptions as there can be cases where you are no longer taking the medication, your doctor has changed your dose, etc. However, we provide a friendly refill reminder service. We will kindly notify you by phone or email as to the best time to place a refill order based on your prescription history.

Drug Information

About Xifaxan (Rifaximin)

What is Xifaxan?

Xifaxan is a prescription medication that is classified as a rifamycin antibacterial.


What is Xifaxan used for?

Xifaxan is used for the treatment of traveler’s diarrhea (TD) caused by noninvasive strains of Escherichia coli in patients aged 12 and up. Rifaximin cannot be used to treat patients with traveler’s diarrhea who have a fever and/or blood in stool or are presumed to be infected with a different pathogen than Escherichia coli. Rifaximin can also be used to reduce the risk of recurrence of overt hepatic encephalopathy (HE) in patients aged 18 years and older. Xifaxan is also used for the treatment of irritable bowel syndrome with diarrhea (IBS-D) in patients aged 18 years and older.

How does it work?

Xifaxan binds to bacterial DNA-dependent RNA polymerase and blocks a step of transcription which inhibits bacterial protein synthesis and thus inhibits bacterial growth.


How do I take Xifaxan?

Xifaxan can be taken with or without food. Take this medication as prescribed, taking more of this medication is not advised.

What dosages are available?

Xifaxan is available by brand-only as 200 mg and 550 mg tablets.

What is the recommended dosage?

Xifaxan is typically taken three times daily for the treatment of traveler’s diarrhea or IBS-D and typically twice daily for hepatic encephalopathy but take as directed by your doctor. The recommended dosage for TD is 200 mg three times daily, 550 mg three times daily for IBS-D, and 550 mg twice daily for HE. Duration of therapy varies among the indications.

What is the maximum dosage?

The maximum recommended dosage is 1,650 mg/day.

What if I miss a dose?

Take the missed dose as soon as you remember unless it is close to the time you are due for your next dose. If that is the case, just wait until it is time for your next dose. Do not double your dose to compensate for your missed dose.

Warnings & Precautions

What should you know before you take Xifaxan?

Xifaxan has not been shown to be effective in treating traveler’s diarrhea due to pathogens other than Escherichia coli. If diarrhea worsens or does not improve in two days, discontinue and alert your physician.

There is a risk of acquiring Xifaxan-induced Clostridium difficile diarrhea which can be observed if diarrhea does not improve or improves and then there is an onset of diarrhea upon completion of therapy.

Use with caution in patients with severe hepatic impairment.

Use caution when using concomitantly with p-glycoprotein inhibitors.

Side Effects

What are the side effects of Xifaxan?

Side effects may differ between the different indications for Xifaxan use.

Common side effects for the treatment of TD include (≥2%):

  • Headache

Common side effects for the treatment of HE include (≥10%):

  • Swelling of lower extremities and/or abdomen
  • Nausea, dizziness, fatigue

Common side effects for the treatment of IBS-D include (≥2%):

  • Increase in alanine aminotransferase (ALT)
  • Nausea

Speak to your doctor for a full list of side effects.


Does this medication interact with other drugs, foods, or alcohol?

  • Xifaxan can induce CYP3A4 but at the current recommended dosing regimen, this interaction is not expected to have a significant clinical impact unless the patient has reduced liver function.
  • An increase in systemic exposure of Xifaxan is observed when given with p-glycoprotein inhibitors.
  • Changes in INR have been observed when taking Rifaximin concomitantly with warfarin and more frequent monitoring of INR levels may be required.


How should this medication be stored?

Keep Xifaxan in the original container and store it in a dry place at room temperature 15-30°C (59-86°F).

Pharmacist Tips

  • Xifaxan will not work faster or more effectively if you take it more than the recommended dose.
  • Xifaxan should only be used for the treatment or prevention of infections that are proven to be caused by susceptible bacteria to reduce the risk of resistance.
  • Xifaxan may cause dizziness. Avoid activities that require coordination until the effects of this medication on your body are known.
  • Report watery or bloody diarrhea immediately to your physician as this may be Clostridium difficile-associated diarrhea.

The above information is an educational aid only. It is not intended as medical advice for individual conditions or treatments. Talk to your doctor, nurse or pharmacist before following any medical regimen to see if it is safe and effective for you.


Xifaxan Coupon
Use Xifaxan coupon code to get $10 discount. Minimum $100 purchase required. *Coupon codes are one-time use and cannot be combined.

Xifaxan FAQ

How does Xifaxan work?

It stops the growth of bacteria.

How quickly does Xifaxan work?

In a clinical trial, relief of symptoms was observed in two weeks.

Is Xifaxan a strong antibiotic?

It is a gut-selective broad-spectrum antibiotic that has an excellent safety profile.

Does Xifaxan cure IBS?

There is currently no cure for IBS but this medication has been shown to reduce symptoms of IBS. Symptom relief was maintained for 10 weeks after completing two weeks of therapy.

Can you become resistant to Xifaxan?

Resistance is always a concern with antibiotics but unlike other antibiotics, resistance to this medication is not common.

The above information is an educational aid only. It is not intended as medical advice for individual conditions or treatments. Talk to your doctor, nurse or pharmacist before following any medical regimen to see if it is safe and effective for you.