Xiidra (Lifitegrast)

Rx Prescription Required

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Xiidra Ophthalmic Solution 5%


Medically reviewed by Dr. Samuel Maaiah, PharmD

Last updated: April 10, 2024

Dr. Maaiah is a PharmD graduate who has practiced both in pharmaceutical consulting and retail pharmacy. His interests include consulting and the development and approval of new therapeutics. He currently works as a Medical Information Consultant (MIC) and as a retail pharmacist. As a MIC he helps pharmaceutical companies with projects and by consulting as a medical information expert.

When Dr. Maaiah is not working, he enjoys spending time with his family and friends, doing outdoor activities, working out, and reading.

Order Online

How to buy Xiidra (Lifitegrast) online?

Xiidra (Lifitegrast) can be ordered online through CanadianPharmacyOnline.com or by calling 1-800-828-4489 and speaking to customer support. The chat feature can also be used for support. For more information please visit the “How to Order” page.

Is a prescription required?

Yes, a valid prescription from your doctor is required. Xiidra (Lifitegrast) is a prescription medication and can only be sold with a prescription. To process your order, you will need to submit a prescription. The prescription can be emailed ([email protected]), faxed (1-800-416-8019), or uploaded. Alternatively, we can reach out to your doctor to attain a valid prescription if you would like.

What is the maximum amount that can be ordered?

A 3-month supply (90 days) is the maximum amount that can be ordered at one time. Refills are kept on file for future orders. The amount that can be ordered will be based on the directions and quantity indicated on the prescription from your provider.

Is it safe to order from Canadian Pharmacy Online?

Absolutely. All our partner pharmacies are fully licensed and certified in their respective countries. We ensure that your shopping experience is safe and secure with our Norton Shopping Guarantee. We operate just like your local pharmacy would, with our main priority being to provide you access to safe and affordable prescription medication.

Xiidra Cost

How much does Xiidra (Lifitegrast) cost?

Xiidra 5% – 60 Ampules

  • Average US retail price – $682.96
  • Our Price – $495.00

At CanadianPharmacyOnline.com, we make sure to keep drug prices low. You can view the Xiidra (Lifitegrast) cost savings below:

We provide brand Xiidra (Lifitegrast) 5% ampules here at Canadian Pharmacy Online. A quantity of 60 ampules of Xiidra (Lifitegrast) costs $495, which comes out to $8.25 per unit.

Below shows the price comparison of brand Xiidra (Lifitegrast) 5% at a quantity 60 ampules between the average U.S. retail price and Canadian Pharmacy Online price.

What is the lowest price of Xiidra (Lifitegrast) per unit?

Lowest Price Per Unit: $8.08/unit for Xiidra (Lifitegrast) 5% ampules

Is this price for Xiidra (Lifitegrast) without insurance?

The listed prices above are not including insurance. Unfortunately, we are not able to accept insurance. However, we will give you an official receipt which you can use to apply for reimbursement with your insurer since we are unable to adjudicate with US insurance providers.

Why is Xiidra (Lifitegrast) cheaper from Canada than from the United States?

The cost of medications ordered from India, Canada, and Turkey are internally controlled by the respective governments. The US is a free market economy which is why the price differs because pharmaceutical suppliers can charge what they consider appropriate for the product. As a result, we can offer lower prices to our patients as we supply medications from these countries.

Xiidra Coupon

Is there a coupon for Xiidra available?

Yes, we do you have a Xiidra coupon for an extra discount on your prescription. You can save $10 off your order with coupon code XIIDRA10. Apply coupon at checkout for instant savings and pay less for your prescription with a minimum $100 order.

Xiidra Generic

Is there a lower cost generic Xiidra (Lifitegrast) available?

Xiidra (Lifitegrast) is not available as a generic alternative.

How much cheaper is generic Xiidra (Lifitegrast)?

There is currently no generic alternative to Xiidra (Lifitegrast).

What is the difference between brand and generic Xiidra (Lifitegrast)?

Once available on the market, there will be no difference between generic and brand Xiidra (Lifitegrast). Generic formulations of medications contain the same active ingredients and meet the same quality, strength, and purity standards as the brand formulation.


Is shipping available to the United States?

Yes. An email notification will be sent to you once the item has been shipped. We ship nationwide across the United States.

How much does shipping cost?

There are no standard shipping fees.

Is express shipping available?

If a product of Canada is available then express shipping can be selected with an estimated delivery time of 3-5 business days. You have the option at the checkout page to select the express shipping option ($25) if available for that medication source.

Refill Rx

How to refill a prescription?

Refilling your prescription is made easy with Canadian Pharmacy Online. You can sign into your online account and view your previous orders and see which prescriptions we have on file. Placing a refill order online is made simple by accessing the reorder section in your account.

You can also call us at 1-800-416-8019 and speak to customer support to place a refill. Our live chat is also a great place to connect with us to place a refill order while you are on the go.

Are prescriptions automatically refilled?

We do not automatically refill prescriptions as there can be cases where you are no longer taking the medication, your doctor has changed your dose, etc. However, we provide a friendly refill reminder service. We will kindly notify you by phone or email as to the best time to place a refill order based on your prescription history.

Drug Information

About Xiidra (Lifitegrast)

What is Xiidra (Lifitegrast)? 

Xiidra (Lifitegrast) is a prescription medication that is classified as a lymphocyte function-associated antigen-1 (LFA-1) antagonist. It is approved in patients aged 17 and older.


What is Xiidra (Lifitegrast) used for?

It is used for the treatment of the signs and symptoms of dry eye disease (DED).

How does it work?

Xiidra (Lifitegrast) binds to the integrin lymphocyte function-associated antigen-1 (LFA-1) and blocks it from binding to its cognate ligand intercellular adhesion molecule-1 (ICAM-1) which inhibits secretion of inflammatory cytokines.


How do I take Xiidra (Lifitegrast)?

Xiidra (Lifitegrast) should be taken as directed by your physician. Each ampule is a single-use container; dispose of the container after using in each eye. Remove contact lenses prior to using this medication and wait at least 15 minutes before reinserting. Keep the ampules in their original foil pouches until you are ready to use them.

What dosages are available?

Xiidra (Lifitegrast) is available as a brand 5% (50 mg/mL) ophthalmic solution.

What is the recommended dosage?

It is typically dosed one drop into the affected eye(s) twice daily (about 12 hours apart) but always use as directed by your doctor.

What is the maximum dosage?

The maximum recommended dosage is 1 drop into each eye twice daily.

What if I miss a dose?

If you forget to use Xiidra (Lifitegrast), use it as soon as you remember. If it is relatively close to when your next dose is due, wait until then and take your normal dose. Do not use an extra dose to make up for the missed dose.

Warnings & Precautions

What should you know before you take Xiidra (Lifitegrast)?

No data available to support use in pregnant women

No data to indicate if Xiidra passes into breast milk, alters milk production, or if it has effects on the breastfed infant

Safety and efficacy in patients aged less than 17 years have not been established

Side Effects

What are the side effects of Xiidra (Lifitegrast)?

Some common (5-25%) side effects include:

  • Eye irritation
  • Discomfort
  • Blurred vision
  • Unusual taste sensation (dysgeusia)

Speak to your doctor for a full list of side effects.


Does this medication interact with other drugs, foods, or alcohol?

No significant interactions have been reported due to relatively low systemic absorption from ophthalmic administration


How should this medication be stored?

Xiidra (Lifitegrast) should be stored in the original foil packaging at room temperature (68°F to 77°F)

Pharmacist Tips

  • Efficacy is indicated by improvement of symptoms associated with DED
  • Let your doctor know if your symptoms do not improve or worsen while using this medication
  • This medication works best if you do not miss doses; taking it at a scheduled time may help minimize missed doses
  • Let your doctor know if you are pregnant, plan to become pregnant, or are breastfeeding

The above information is an educational aid only. It is not intended as medical advice for individual conditions or treatments. Talk to your doctor, nurse or pharmacist before following any medical regimen to see if it is safe and effective for you.


Xiidra Coupon
Use Xiidra coupon code to get $10 discount. Minimum $100 purchase required. *Coupon codes are one-time use and cannot be combined.

Xiidra FAQ

What does Xiidra do for your eyes?

It binds to certain proteins in your eye to reduce inflammation which will help improve symptoms of DED.

Can Xiidra damage your eyes?

Common side effects include: eye irritation, discomfort, and blurred vision but these are when drops are instilled into the eye and have not been reported to be permanent.

Is Xiidra an over-the-counter drug?

No, it contains lifitegrast which is a prescription medication and therefore, a prescription is required.

Is there an alternative to Xiidra?

A generic alternative is not yet available. Over-the-counter products that contain glycerin and propylene glycol, povidone, or carboxymethylcellulose can be used for temporary relief of symptoms of DED but do not increase the eye’s ability to produce tears.

Can I use regular eye drops with Xiidra?

Only use prescription eye drops with Xiidra if it has been approved by your doctor. Some over-the-counter drops may work similarly to Xiidra so ask your doctor before using them as well.

The above information is an educational aid only. It is not intended as medical advice for individual conditions or treatments. Talk to your doctor, nurse or pharmacist before following any medical regimen to see if it is safe and effective for you.