Glyxambi (Empaglifozin/Linagliptin)

Rx Prescription Required

Select your dosage below to view Glyxambi cost and place your order. Save up to 90% and get FREE standard shipping on prescription medication delivered to your door.

Glyxambi 10mg/5mg
Empagliflozin, Linagliptin
Boehringer Ingelheim
Glyxambi 25mg/5mg
Empagliflozin, Linagliptin
Boehringer Ingelheim
Glyxambi 10mg/5mg
Empagliflozin, Linagliptin
Boehringer Ingelheim
Glyxambi 10mg/5mg
Empagliflozin, Linagliptin
Boehringer Ingelheim
Glyxambi 25mg/5mg
Empagliflozin, Linagliptin
Boehringer Ingelheim


Medically reviewed by Dr. Samuel Maaiah, PharmD

Last updated: April 10, 2024

Dr. Maaiah is a PharmD graduate who has practiced both in pharmaceutical consulting and retail pharmacy. His interests include consulting and the development and approval of new therapeutics. He currently works as a Medical Information Consultant (MIC) and as a retail pharmacist. As a MIC he helps pharmaceutical companies with projects and by consulting as a medical information expert.

When Dr. Maaiah is not working, he enjoys spending time with his family and friends, doing outdoor activities, working out, and reading.

Order Online

How to buy Glyxambi (Empagliflozin and Linagliptin) online?

Glyxambi can be ordered online through or by calling 1-800-828-4489 and speaking to customer support. The chat feature can also be used for support. For more information please visit the “How to Order” page.

Is a prescription required?

Yes, a valid prescription from your doctor is required. Glyxambi is a prescription medication and can only be sold with a prescription. To process your order, you will need to submit a prescription. The prescription can be emailed ([email protected]), faxed (1-800-416-8019), or uploaded Alternatively, we can reach out to your doctor to attain a valid prescription if you would like.

What is the maximum amount that can be ordered?

A 3-month supply (90-days) is the maximum amount that can be ordered at one time. Refills are kept on file for future orders. The amount that can be ordered will be based on the directions and quantity indicated on the prescription from your provider.

Is it safe to order Glyxambi online from Canadian Pharmacy Online?

Absolutely. All our partner pharmacies are fully licensed and certified in their respective countries. We ensure that your shopping experience is safe and secure with our Norton Shopping Guarantee. We operate just like your local pharmacy would, with our main priority being to provide you access to safe and affordable prescription medication.

Glyxambi Cost

How much does Glyxambi (Empagliflozin and Linagliptin) cost?

Glyxambi 25mg/5mg – 90 Tablets

  • Average US retail price – $1996.00
  • Our Price – $320.00

We provide the brand version, Glyxambi, here at Canadian Pharmacy Online. Above shows the comparison between the average U.S. retail price and Canadian Pharmacy Online price for 90 tablets of Glyxambi 25 mg/5 mg.

What is the lowest price of Glyxambi (Empagliflozin/Linagliptin) per unit?

Lowest Price Per Unit: $3.61/unit for Glyxambi (Empagliflozin/Linagliptin) 25mg/5mg tablets

Is this price for Glyxambi (Empagliflozin/Linagliptin) without insurance?

These prices mentioned are without insurance. Unfortunately, we cannot accept insurance. However, we will give you an official receipt which you can use to apply for reimbursement with your insurer. We are unable to process claims with US insurance providers.

Why is Glyxambi (Empagliflozin/Linagliptin) cheaper from Canada than from the United States?

Drug pricing in Canada is regulated. Since the US is a free market economy, the price may differ since pharmaceutical suppliers can charge what they determine to be appropriate for the product. As a result, we can offer lower prices to our patients as we utilize medications from these countries.

Glyxambi Coupon

Is there an Glyxambi coupon available?

Sorry, we do not have an Glyxambi coupon available at this time.

Glyxambi Generic

Is there a lower cost generic Glyxambi (Empagliflozin/Linagliptin) available?

Glyxambi (Empagliflozin/Linagliptin) is not available as a generic alternative.

How much cheaper is generic Glyxambi (Empagliflozin/Linagliptin)?

There is currently no generic alternative to Glyxambi (Empagliflozin/Linagliptin). 

What is the difference between brand and generic Glyxambi (Empagliflozin/Linagliptin)?

Once available on the market, there will be no difference between generic and brand Glyxambi (Empagliflozin/Linagliptin). Generic formulations of medications contain the same active ingredients and meet the same quality, strength, and purity standards as the brand formulation.


Is shipping available to the United States?

Yes. An email notification will be sent to you once the item has been shipped. There are no shipping charges.

Is express shipping available?

If a product of Canada is available then express shipping can be selected with an estimated delivery time of 3-5 business days. You have the option at the checkout page to select the express shipping option ($25) if available for that medication source.

Refill Rx

How to refill a prescription?

Refilling your prescription is made easy with Canadian Pharmacy Online. You can sign into your online account and view your previous orders and see which prescriptions we have on file. Placing a refill order online is made simple by accessing the reorder section in your account.
You can also call us at 1-800-416-8019 and speak to customer support to place a refill. Our live chat is also a great place to connect with us to place a refill order while you are on the go

Are prescriptions automatically refilled?

We do not automatically refill prescriptions as there can be cases where you are no longer taking the medication, your doctor has changed your dose, etc. However, we provide a friendly refill reminder service. We will kindly notify you by phone or email as to the best time to place a refill order based on your prescription history.

Drug Information

About Glyxambi (Empaglifozin/Linagliptin)

What is Glyxambi (Empagliflozin/Linagliptin)? 

Glyxambi (Empagliflozin/Linagliptin) is a prescription medication that is classified as a combination of a sodium-glucose cotransporter 2 (SGLT2) inhibitor (empagliflozin) and a dipeptidyl peptidase 4 (DPP-4) inhibitor (linagliptin).


What is Glyxambi used for? 

It is used for the treatment of type 2 diabetes mellitus. To note, empagliflozin is indicated for risk reduction of cardiovascular mortality in adults with established cardiovascular disease and type 2 diabetes mellitus.

How does it work?

Empagliflozin increases urinary glucose excretion while linagliptin increases the levels of incretin hormones which stimulates glucose-dependent insulin release.


How do I take Glyxambi?

Take Glyxambi by mouth with or without food at the same time every morning as directed by your doctor.

What dosages are available?

Glyxambi (Empagliflozin/Linagliptin) only comes as a brand name in 10 mg/5 mg and 25 mg/5 mg tablets.

What is the recommended dosage?

It is typically dosed 10mg/5mg once daily but take as directed by your doctor.

What is the maximum dosage?

The maximum recommended dosage is 25mg/5mg per day.

What if I miss a dose?

Take the medication as soon as possible if you have missed a dose. If it is almost time for your next dose, skip the missed dose and return back to your regular schedule. Never double the dose.

Warnings & Precautions

What should you know before you take Glyxambi (Empagliflozin/Linagliptin)?

The Institute for Safe Medication Practices (ISMP) includes Glyxambi on its list for drugs that are at increased risk of causing significant patient harm when used in error.

Severe/disabling arthralgia has been reported with DPP-4 inhibitors. Onset can occur within a day to years after starting therapy.

There have been reports of increased bone fractures with SGLT2 inhibitors in some clinical trials, but meta-analysis data of empagliflozin has not shown an increased risk of bone fractures.

Hypersensitivity reactions can occur, usually within hours to days of starting therapy. Stop therapy and treat appropriately if hypersensitivity reactions occur.

Empagliflozin can cause hypotension due to intravascular volume depletion (increased risk in those with renal dysfunction).

Necrotizing fasciitis (Fournier gangrene), although rare and serious, has been reported in patients taking empagliflozin. Patients with malaise along the genitil, fever, or tenderness, erythema, perennial pain, or swelling should be assessed for necrotizing fasciitis. Stop the medication immediately if the patient develops this.

There have been reports of pancreatitis in those taking linagliptin. Glyxambi has not been studied in those with a history of pancreatitis.

Use of Glyxambi may increase the risk of genital mycotic infections. Uncircumcised males and patients with a history of these infections are at increased risk.

Kidney dysfunction may require a dose adjustment

  • eGFR > 45 mL/minute/1.73m2: No dose adjustment needed.
  • eGFR 30 to 45 mL/minute/1.73m2: Do not initiate therapy. If patients are already on it, discontinue the medication if eGFR is persistently < 45 mL/min/1.73m2. Also refer to the individual agents in Glyxambi (empagliflozin and linagliptin).
  • eGFR < 30 mL/minute/1.73m2: Contraindicated
  • End-stage renal disease (ESRD) or dialysis: Contraindicated

Treatment with a DDP-4 inhibitor has been associated with heart failure. However, a large-randomized, double-blinded study in patients with established cardiovascular disease and type 2 diabetes showed that the occurrence of the primary composite outcome (CAD, atherosclerotic peripheral arterial disease, or ischemic cerebrovascular disease) and the occurrence of the primary composite cardiovascular outcome (nonfatal MI, nonfatal stroke, cardiovascular death, or hospitalization for unstable angina) with sitagliptin was found to be noninferior to placebo. The rate of hospitalization for heart failure did not differ between the two groups. The American Diabetes Association (ADA) suggests that DPP-4 inhibitors (except saxagliptin) can be considered in patients with heart failure.

Side Effects

What are the side effects of Glyxambi (Empagliflozin/Linagliptin)?

Some common side effects include:

  • Genitourinary fungal infections
  • Hypotension
  • Hypovolemia
  • Increased urinary output
  • Urinary tract infection
  • Vulvovaginal pruritus
  • Nasopharyngitis

Speak to your doctor for a full list of side effects that apply to you if you are taking Glyxambi.


Does this medication interact with other drugs, foods, or alcohol?

Use with sulfonylureas may increase the risk of hypoglycemic effect of the sulfonylurea. A dose decrease of the sulfonylurea should be considered when starting a DPP-4 inhibitor (Risk Category D).

This is not a full list of potential drug-drug-interactions. Speak to your doctor if you have any concerns about drug-drug-interactions.


How should this medication be stored?

Store your Glyxambi at 25°C (77°F). Excursions are allowed to be stored between 15°-30°C (59°-86°F).

Pharmacist Tips

  • Dehydration can occur so be sure to stay hydrated. Dehydration can cause you to feel weak, faint, dizzy, or lightheaded.
  • Taking Glyxambi can increase your risk of yeast infection (in males and females).

The above information is an educational aid only. It is not intended as medical advice for individual conditions or treatments. Talk to your doctor, nurse or pharmacist before following any medical regimen to see if it is safe and effective for you.


Save $10 on your first order!
Enter Canadian Pharmacy Online coupon code CPO10 to save $10 off your order. Minimum $50 order value. *Coupon codes are one-time use and cannot be combined.

Glyxambi FAQ

Is Glyxambi an insulin?

No. Glyxambi is a SGLT2 inhibitor (empagliflozin) and DPP4-inhibitor (linagliptin).

What is Glyxambi used for?

The treatment of type 2 diabetes. Glyxambi is also indicated for risk reduction of cardiovascular mortality in adults with established cardiovascular disease and type 2 diabetes mellitus.

What class of drug is Glyxambi?

Glyxambi belongs to the SGLT2 inhibitors and DPP4-inhibitors. It is a combination medication.

Is Glyxambi good for diabetes?

Glyxambi has an FDA-labeled indication for the treatment of type 2 diabetes. It is effective along with diet and exercise in lowering blood sugar levels.

Is Glyxambi generic?

There is no generic for Glyxambi.

The above information is an educational aid only. It is not intended as medical advice for individual conditions or treatments. Talk to your doctor, nurse or pharmacist before following any medical regimen to see if it is safe and effective for you.