Synvisc One (Hylan G-F 20)

Rx Prescription Required

Select your dosage below to view Synvisc injection cost and place your order. Save up to 90% and get FREE standard shipping on prescription medication delivered to your door.

Synvisc One 8mg/mL
Hylan G-F 20


Medically reviewed by Dr. Samuel Maaiah, PharmD

Last updated: April 10, 2024

Dr. Maaiah is a PharmD graduate who has practiced both in pharmaceutical consulting and retail pharmacy. His interests include consulting and the development and approval of new therapeutics. He currently works as a Medical Information Consultant (MIC) and as a retail pharmacist. As a MIC he helps pharmaceutical companies with projects and by consulting as a medical information expert.

When Dr. Maaiah is not working, he enjoys spending time with his family and friends, doing outdoor activities, working out, and reading.

Order Online

How to buy Synvisc One online?

Synvisc One can be ordered online through or by calling 1-800-828-4489 and speaking to customer support. The chat feature can also be used for support. For more information please visit the “How to Order” page.

Is a prescription required?

Yes, a valid prescription from your doctor is required. Synvisc One is a prescription medication and can only be sold with a prescription. To process your order, you will need to submit a prescription. The prescription can be emailed ([email protected]), faxed (1-800-416-8019), or uploaded. Alternatively, we can reach out to your doctor to attain a valid prescription if you would like.

What is the maximum amount that can be ordered?

A 3-month supply (90 days) is the maximum amount that can be ordered at one time. Refills are kept on file for future orders. The amount that can be ordered will be based on the directions and quantity indicated on the prescription from your provider.

Is it safe to order from Canadian Pharmacy Online?

Absolutely. All our partner pharmacies are fully licensed and certified in their respective countries. We ensure that your shopping experience is safe and secure with our Norton Shopping Guarantee. We operate just like your local pharmacy would, with our main priority being to provide you access to safe and affordable prescription medication.

Synvisc One Cost

How much does Synvisc One cost?

Synvisc One 48 mg/6mL – (1 syringe) 

  • Average US retail price – $1643.54
  • Our price – $123.67

At, we make sure to keep drug prices low. You can view the Synvisc One cost savings below:

We provide brand Synvisc One 48 mg/6 mL syringes here at Canadian Pharmacy Online. A quantity of 1 syringe of Synvisc One costs $742, which comes out to $123.67 per unit.

Below shows the price comparison of Synvisc Oneat a quantity of 1 syringe between the average U.S. retail price and Canadian Pharmacy Online price.

What is the lowest price of Synvisc One per unit?

Lowest Price Per Unit: $123.67/unit for Synvisc One 48 mg/6 mL syringes.

Is this price for Synvisc One without insurance?

The prices mentioned above are not processed through insurance. Although we cannot accept insurance, we will give you an official receipt which you can use to apply for reimbursement with your insurer. We are also unable to adjudicate with US insurance providers.

Why is Synvisc One cheaper from Canada than from the United States?

Drug prices are negotiated and regulated in Canada. Because the US is a free market economy, the price differs since pharmaceutical suppliers can charge what they deem appropriate for the product. As a result, we can offer lower prices to our patients as we supply medications from these countries.

Synvisc One Coupon

Is there a coupon for Synvisc One available?

Sorry, we do not have a Synvisc One Coupon at this time.

Synvisc One Generic

Is there a lower cost generic Synvisc One available?

Synvisc One is not available as a generic alternative.

How much cheaper is generic Synvisc One?

There is currently no generic alternative to Synvisc One.

What is the difference between brand and generic Synvisc One?

Once available on the market, there will be no difference between generic and brand Synvisc One. Generic formulations of medications contain the same active ingredients and meet the same quality, strength, and purity standards as the brand formulation.


Is shipping available to the United States?

Yes. An email notification will be sent to you once the item has been shipped. We ship nationwide across the United States.

How much does shipping cost?

There are no standard shipping fees.

Is express shipping available?

If a product of Canada is available then express shipping can be selected with an estimated delivery time of 3-5 business days. You have the option at the checkout page to select the express shipping option ($25) if available for that medication source.

Refill Rx

How to refill a prescription?

Refilling your prescription is made easy with Canadian Pharmacy Online. You can sign into your online account and view your previous orders and see which prescriptions we have on file. Placing a refill order online is made simple by accessing the reorder section in your account.
You can also call us at 1-800-416-8019 and speak to customer support to place a refill. Our live chat is also a great place to connect with us to place a refill order while you are on the go.

Are prescriptions automatically refilled?

We do not automatically refill prescriptions as there can be cases where you are no longer taking the medication, your doctor has changed your dose, etc. However, we provide a friendly refill reminder service. We will kindly notify you by phone or email as to the best time to place a refill order based on your prescription history.

Drug Information

About Synvisc One (Hylan G-F 20)

What is Synvisc One?

Synvisc One is a prescription medication that is classified as a musculoskeletal agent and cartilaginous defect repair agent.


What is Synvisc One used for? 

It is used for osteoarthritic pain in patients that have responded unsuccessfully to analgesics and non-pharmacologic treatment.

How does it work? 

Hylans are derivatives of hyaluronan which is a natural substance found in the joints where it acts as a lubricant to enable the joint to work properly.


How do I take Synvisc One?

Take this medication as directed by your doctor; the number of injections into the knee joint will be determined by your doctor. This medication will be administered by a healthcare provider at your follow-up visits.

What dosages are available?

Synvisc One is available by brand-only 8 mg/1 mL syringes.

What is the recommended dosage?

Your doctor will determine the number of injections needed based on patient-specific factors.

What is the maximum dosage?

The maximum recommended dosage is 48 mg into the joint.

What if I miss a dose?

This medication is typically given as a single dose or in three divided doses given by a healthcare provider. The follow-up appointments are typically scheduled beforehand to avoid missing doses. If you are unable to make a visit, alert your healthcare provider so they can reschedule you.

Warnings & Precautions

What should you know before you take Synvisc One?

This medication should not be frozen or used if the package has been opened or damaged. It should be stored away from light in its original packaging.

Caution should be exercised when using Synvisc-One in patients with lymphatic or venous stasis or lymphatic in the leg that will be receiving the injection.

Synvisc-One has not been shown to be effective or safe other than osteoarthritis in the knee.

Side Effects

What are the side effects of Synvisc One?

Some common side effects (≥5%) include:

  • arthralgia
  • joint effusion
  • arthritis
  • arthropathy
  • injection site pain

Speak to your doctor for a full list of side effects.


Does this medication interact with other drugs, foods, or alcohol?

There are no known drug-drug interactions with Synvisc One


How should this medication be stored?

This medication should be stored at room temperature below 86°F and away from light. This medication should not be freezed.

Pharmacist Tips

  • Patients should wait at least 48 hours post-injection before participating in demanding activities such as sports or persistent weight-bearing activities.
  • This medication is intended to be used immediately once it has been removed from packaging.
  • Do not freeze this medication.
  • Avoid using the same syringe  to remove the synovial fluid and perform Synvisc-One injections.

The above information is an educational aid only. It is not intended as medical advice for individual conditions or treatments. Talk to your doctor, nurse or pharmacist before following any medical regimen to see if it is safe and effective for you.


Save $10 on your first order!
Enter Canadian Pharmacy Online coupon code CPO10 to save $10 off your order. Minimum $50 order value. *Coupon codes are one-time use and cannot be combined.

Synvisc One FAQ

How long does Synvisc-One last?

It may provide relief of osteoarthritic knee pain for up to 6 months.

Is Synvisc-One a steroid?

No, it is not a steroid.

How quickly does Synvisc-One work?

Greatest relief from symptoms occurs between 8-12 weeks after first injection.

Is Synvisc-One safe in pregnancy and breastfeeding?

There is not enough evidence to determine the safety and efficacy of this medication in patients that are pregnant or breastfeeding.

Do Synvisc-One injections hurt?

The injections may be painful, however they are typically tolerable.

The above information is an educational aid only. It is not intended as medical advice for individual conditions or treatments. Talk to your doctor, nurse or pharmacist before following any medical regimen to see if it is safe and effective for you.