Xeljanz (Tofacitinib)

Rx Prescription Required

Select your dosage below to view Xeljanz cost and place your order. Save up to 90% and get FREE standard shipping on prescription medication delivered to your door.


Medically reviewed by Dr. Samuel Maaiah, PharmD

Last updated: April 10, 2024

Dr. Maaiah is a PharmD graduate who has practiced both in pharmaceutical consulting and retail pharmacy. His interests include consulting and the development and approval of new therapeutics. He currently works as a Medical Information Consultant (MIC) and as a retail pharmacist. As a MIC he helps pharmaceutical companies with projects and by consulting as a medical information expert.

When Dr. Maaiah is not working, he enjoys spending time with his family and friends, doing outdoor activities, working out, and reading.

Order Online

How to buy Xeljanz (Tofacitinib) online?

Xeljanz (Tofacitinib) can be ordered online through CanadianPharmacyOnline.com or by calling 1-800-828-4489 and speaking to customer support. The chat feature can also be used for support. For more information please visit the “How to Order” page.

Is a prescription required?

Yes, a valid prescription from your doctor is required. Xeljanz (Tofacitinib) is a prescription medication and can only be sold with a prescription. To process your order, you will need to submit a prescription. The prescription can be emailed ([email protected]), faxed (1-800-416-8019), or uploaded. Alternatively, we can reach out to your doctor to attain a valid prescription if you would like.

What is the maximum amount that can be ordered?

A 3-month supply (90 days) is the maximum amount that can be ordered at one time. Refills are kept on file for future orders. The amount that can be ordered will be based on the directions and quantity indicated on the prescription from your provider.

Is it safe to order from Canadian Pharmacy Online?

Absolutely. All our partner pharmacies are fully licensed and certified in their respective countries. We ensure that your shopping experience is safe and secure with our Norton Shopping Guarantee. We operate just like your local pharmacy would, with our main priority being to provide you access to safe and affordable prescription medication.

Xeljanz Cost

How much does Xeljanz (Tofacitinib) cost?

Xeljanz 10 mg – 60 Tablets

  • Average US retail price – $6,103.43
  • Our price – $3,299.00

At CanadianPharmacyOnline.com, we make sure to keep drug prices low. You can view the Xeljanz (Tofacitinib) cost savings above with the price comparison of Xeljanz 10mg between the average U.S. retail price and Canadian Pharmacy Online price.

What is the lowest price of Xeljanz (Tofacitinib) per unit?

Lowest Price Per Unit: $14.27/unit for Xeljanz (Tofacitinib) 5mg tablets 

Is this price for Xeljanz (Tofacitinib) without insurance?

The listed prices above are without insurance. Unfortunately, we are not able to accept insurance. However, we will give you an official receipt which you can use to apply for reimbursement with your insurer. We are  unable to adjudicate with US insurance providers.

Why is Xeljanz (Tofacitinib) cheaper from Canada than from the United States?

Drug prices in Canada and from other countries we source medication from are negotiated and regulated. The US is a free market economy which is why the price differs since pharmaceutical suppliers can charge what they consider appropriate for the product. As a result, we can offer lower prices to our patients as we utilize medications from these countries. 

Xeljanz Coupon

Is there a coupon for Xeljanz (Tofacitinib) available?

Sorry , we do not have a Xeljanz Coupon at this time.

Xeljanz Generic

Is there a lower cost generic Xeljanz (Tofacitinib) available?

Xeljanz (Tofacitinib) is not available as a generic alternative.

How much cheaper is generic Xeljanz (Tofacitinib)?

There is currently no generic alternative.

What is the difference between brand and generic Xeljanz (Tofacitinib)?

Once available on the market, there will be no difference between generic and brand Xeljanz. Generic formulations of medications contain the same active ingredients and meet the same quality, strength, and purity standards as the brand formulation. 


Is shipping available to the United States?

Yes. An email notification will be sent to you once the item has been shipped. We ship nationwide across the United States.

How much does shipping cost?

Standard shipping is free.

Is express shipping available?

If a product of Canada is available then express shipping can be selected with an estimated delivery time of 3-5 business days. You have the option at the checkout page to select the express shipping option ($25) if available for that medication source.

Refill Rx

How to refill a prescription?

Refilling your prescription is made easy with Canadian Pharmacy Online. You can sign into your online account and view your previous orders and see which prescriptions we have on file. Placing a refill order online is made simple by accessing the reorder section in your account.

You can also call us at 1-800-416-8019 and speak to customer support to place a refill. Our live chat is also a great place to connect with us to place a refill order while you are on the go.

Are prescriptions automatically refilled?

We do not automatically refill prescriptions as there can be cases where you are no longer taking the medication, your doctor has changed your dose, etc. However, we provide a friendly refill reminder service. We will kindly notify you by phone or email as to the best time to place a refill order based on your prescription history.

Drug Information

About Xeljanz (Tofacitinib))

What is Xeljanz (Tofacitinib)?

Xeljanz (Tofacitinib) is a prescription medication that is classified as an janus kinase (JAK) inhibitor.


What is Xeljanz used for?

 It is used to treat rheumatoid arthritis (RA), psoriatic arthritis, and ulcerative colitis (UC). 

How does it work?

Xeljanz is thought to disrupt Janus kinase (JAK) enzyme activity. This JAK enzyme activates components in the body that initiate the immune response. When the immune response is reduced by Xeljanz then the signs and symptoms of arthritis and ulcerative colitis are reduced.


How do I take Xeljanz (Tofacitinib)?

Xeljanz (Tofacitinib) should be taken as directed by your physician. The immediate release tablets are dosed twice daily and the extended release tablets are dosed once daily. They can be taken without regard for food. 

What dosages are available?

Xeljanz (Tofacitinib) is available as brand 5mg and 10mg immediate release tablets. It is also available in brand 11mg extended release tablets.

What is the recommended dosage?

It is typically dosed 5mg twice daily but take as directed by your provider. 

What is the maximum dosage?

The maximum recommended dosage is 22mg/day.

What if I miss a dose?

If you forget to take Xeljanz (Tofacitinib), take it as soon as you remember. If it is relatively close to when your next dose is due, wait until then and take a normal dose. Do not take an extra dose to make up for the missed dose. 

Warnings & Precautions

What should you know before you take Xeljanz (Tofacitinib)?

This medication can reduce your immune system’s ability to fight off infections. It is not advised that you take it during a serious active infection. 

Although there was not a discernible difference between patients on Xeljanz (Tofacitinib) and placebo with regard to gastrointestinal perforations, patients at increased risk for these perforations should use caution while taking this medication. 

Patients on Xeljanz (Tofacitinib) should have their lymphocyte counts monitored initially and every 3 months thereafter while one therapy. 

Avoid live vaccines while on Xeljanz (Tofacitinib). 

Side Effects

What are the side effects of Xeljanz (Tofacitinib)?

Some common (≥2%) side effects for patients with RA include:

  • Upper respiratory tract infection
  • Nasopharyngitis
  • Diarrhea
  • Heachache

Common (≥5%) side effects for patients with UC include 

  • Nasopharyngitis 
  • Elevated blood cholesterol 
  • Heachache 
  • Upper respiratory tract infection 
  • Increased creatine phosphokinase 
  • Rash 
  • Diarrhea 
  • Herpes zoster

Speak to your doctor for a full list of side effects.


Does this medication interact with other drugs, foods, or alcohol?

Xeljanz (Tofacitinib) is metabolized by CYP3A4. Medications that inhibit or induce this enzyme should be used with caution. Additionally, medications that are immunosuppressive in nature should be avoided where possible. 


How should this medication be stored?

Xeljanz (Tofacitinib) should be stored in the original packaging at room temperature (68°F to 77°F)

Pharmacist Tips

  • Xeljanz (Tofacitinib) may inhibit your ability to fight infections, if you believe you have an active infection contact your physician for a proper evaluation. 
  • If you are of child bearing potential, talk with your doctor prior to taking Xeljanz (Tofacitinib) as it may have fertility implications that may or may not be permanent. 
  • It is recommended that while on this medication you get frequent (every 3 months) blood draws to evaluate the medications impact on your immune system. 

The above information is an educational aid only. It is not intended as medical advice for individual conditions or treatments. Talk to your doctor, nurse or pharmacist before following any medical regimen to see if it is safe and effective for you.


Save $10 on your first order!
Enter Canadian Pharmacy Online coupon code CPO10 to save $10 off your order. Minimum $50 order value. *Coupon codes are one-time use and cannot be combined.

Xeljanz FAQ

What is the best time to take Xeljanz (Tofacitinib)?

This medication may be prescribed as a once daily regimen or a twice daily regimen. If you are instructed to take it once daily, there is no preferred time to take this medication. If you are taking the medication twice daily, separation of doses by about 12 hours is preferred. 

Why is Xeljanz (Tofacitinib) prescribed?

Tofacitinib is a JAK inhibitor medication that is designed to modulate your immune system to aid in therapy in patients with RA or UC. 

Do you have to take Xeljanz (Tofacitinib) with food?

No, this medication can be taken without regard for food. 

Does Xeljanz (Tofacitinib) lower your immune system?

The mechanism of Tofacitinib does have a significant immunosuppressive action. It is not advised to take this medication if you have an active infection. 

Does Xeljanz (Tofacitinib) cause weight gain?

No, Tofacitinib has not been reported to cause variations in weight. 

The above information is an educational aid only. It is not intended as medical advice for individual conditions or treatments. Talk to your doctor, nurse or pharmacist before following any medical regimen to see if it is safe and effective for you.