dexilant vs nexium
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Dexilant vs Nexium: What’s the Difference?

Waking up in the middle of the night with a burning sensation in your chest, or fearing your favorite foods because of the inevitable discomfort they bring – this is the daily reality for millions grappling with GERD. It’s a condition that doesn’t just disrupt your meals. It intrudes into your life, turning everyday joys into sources of anxiety.

Amidst this struggle, the choice of medication becomes a crucial step towards reclaiming your comfort and peace of mind. This is where the often-heard debate of Dexilant vs Nexium comes in. This article will help you understand how the right choice can transform your daily life.

What is Dexilant?

Dexilant is a prescription medication for gastroesophageal reflux disease (GERD). It stands out for its unique dual-release formulation.

This innovative feature allows Dexilant to release a portion of the medication immediately upon ingestion for quick symptom relief. The remaining part is released later to ensure sustained acid suppression over a 24-hour period.

This design is particularly beneficial for those seeking long-lasting relief from GERD symptoms like:

  • Heartburn
  • Regurgitation
  • Chest pain

Beyond symptom relief, Dexilant plays a crucial role in healing esophageal erosions. These are often caused by stomach acid in GERD patients.

By reducing acid exposure to the esophagus, Dexilant aids in the recovery of the damaged esophageal lining. This healing aspect is significant, as it addresses not just the symptoms but also the underlying damage caused by GERD.

However, it’s important to be aware of potential side effects. Commonly reported ones include:

  • Headaches
  • Diarrhea
  • Nausea
  • Abdominal pain
  • Flatulence

These side effects are usually mild and tend to resolve on their own. In rare instances, more serious side effects like severe allergic reactions, liver problems, or low magnesium levels may occur.

It’s also crucial to note that Dexilant can interact with certain types of medications, such as warfarin, digoxin, and some antifungal agents. It can potentially affect their effectiveness or cause adverse reactions.

What is Nexium?

Nexium is another prominent prescription medication used in the treatment of GERD. It operates similarly to Dexilant but has its own distinct characteristics and benefits.

It belongs to the same class of drugs as Dexilant known as proton pump inhibitors (PPIs). These effectively reduce stomach acid production. This reduction in acid helps alleviate common GERD symptoms like heartburn and acid reflux and contributes to an improved quality of life for individuals suffering from this condition.

Like Dexilant, Nexium is also known for its effectiveness in healing esophageal erosions. This therapeutic action is crucial in managing GERD, as it helps repair the damage caused by acid reflux to the esophagus.

However, users of Nexium should also be aware of its potential side effects. These can include:

  • Headache
  • Diarrhea
  • Nausea
  • Abdominal pain

Head-to-Head Comparison: Dexilant vs Nexium

When considering the medication options for treating GERD, Dexilant and Nexium often come up as popular choices with some similarities. However, there are some differences in their effectiveness, side effects, and patient experiences that are worth noting.


Dexilant is known for its dual-release formulation, which offers both immediate and sustained acid suppression over a 24-hour period. This feature is particularly beneficial for consistent symptom relief throughout the day.

Nexium, on the other hand, reaches peak concentrations in the body within one to four hours of an oral dose, but it may take several days of dosing before the maximum effect is achieved. One dose of Nexium provides an effect for up to 24 hours.

Side Effects

Both medications share common side effects like headache, diarrhea, nausea, and abdominal pain.

However, Nexium, as with other PPIs, has been associated with an increased risk of osteoporosis-related fractures. Particularly in those taking medication at high doses for prolonged periods or in older individuals. Additionally, prolonged use of Nexium may lead to vitamin B12 deficiency, particularly in women, younger people, and those on higher doses.

Dexilant, while effective, can cause side effects such as severe allergic reactions, liver problems, or low magnesium levels in rare instances.

Patient Experiences and Suitability

Patient experiences with both medications can vary. Dexilant’s dual-release mechanism might be preferable for those seeking immediate and long-lasting relief. However, it’s important to be cautious of its potential interactions with certain medications like warfarin, digoxin, and some antifungal agents.

Nexium, effective in healing inflamed tissue in the gastrointestinal tract, should be used carefully, especially in the long term. This is due to its association with certain risks such as kidney problems and magnesium deficiency.

Cost and Accessibility

When comparing the costs of Dexilant and Nexium, it’s essential to consider both the brand-name and generic versions.

For a 90-day supply, brand-name Dexilant costs around $285 for 60 mg capsules. Its generic version, dexlansoprazole, is priced at about $95.

In contrast, Nexium’s 40 mg delayed-release capsules are approximately $35 for a 28-day supply.

It’s important to note these prices can vary depending on the pharmacy and are for cash-paying customers without insurance. These are also based on Canadian Pharmacy Online prices which are usually significantly cheaper than other sources.

Making an Informed Choice

Choosing the right medication for GERD involves more than just comparing costs. It’s crucial to consider the effectiveness, potential side effects, and interactions with other drugs.

Both Dexilant and Nexium are effective treatments for GERD, but they may interact with other medications and have side effects that need to be considered. For instance, Dexilant can interact with drugs like warfarin and digoxin, while Nexium may interact with medications such as clopidogrel and cilostazol.

When deciding on the best treatment option, consulting with healthcare providers is key. They can provide personalized advice based on your medical history and current medications.

Additionally, many online pharmacies offer the convenience of pharmacist consultations. These can be an invaluable resource in making an informed decision about your GERD treatment.

Find Your GERD Relief

In our journey through Dexilant vs Nexium, we’ve explored how each medication offers unique benefits for GERD management. Canadian Pharmacy Online is committed to guiding you through these choices to ensure you access the right prescription medications with ease and confidence. Our online platform simplifies your search for effective GERD treatments by offering convenience and affordability.

Don’t let medication stress add to your health concerns. Visit us online today to find your ideal GERD solution and embark on a path to better health.

References / Works Cited