Kombiglyze XR (Saxagliptin Hydrochloride/Metformin Hydrochloride)

Rx Prescription Required

Select your dosage below to view Kombiglyze XR cost and place your order. Save up to 90% and get FREE standard shipping on prescription medication delivered to your door.

Kombiglyze XR 5mg/500mg
Saxagliptin Hydrochloride, Metformin Hydrochloride
Kombiglyze XR 5mg/1000mg
Saxagliptin Hydrochloride, Metformin Hydrochloride
Bristol-Myers Squibb
Kombiglyze XR 2.5mg/1000mg
Saxagliptin Hydrochloride, Metformin Hydrochloride


Medically reviewed by Dr. Samuel Maaiah, PharmD

Last updated: April 10, 2024

Dr. Maaiah is a PharmD graduate who has practiced both in pharmaceutical consulting and retail pharmacy. His interests include consulting and the development and approval of new therapeutics. He currently works as a Medical Information Consultant (MIC) and as a retail pharmacist. As a MIC he helps pharmaceutical companies with projects and by consulting as a medical information expert.

When Dr. Maaiah is not working, he enjoys spending time with his family and friends, doing outdoor activities, working out, and reading.

Order Online

How to buy Kombiglyze XR (Saxagliptin and Metformin) online?

Kombiglyze XR can be ordered online through CanadianPharmacyOnline.com or by calling 1-800-828-4489 and speaking to customer support. The chat feature can also be used for support. For more information please visit the “How to Order” page.

Is a prescription required?

Yes, a valid prescription from your doctor is required to obtain Kombiglyze XR since it is a prescription medication and can only be sold with a prescription. You will need to provide a prescription to process your order. The prescription can be faxed (1-800-416-8019), [email protected] , or uploaded . Alternatively, we can reach out to your doctor on your behalf to obtain a valid prescription if you would like.

What is the maximum amount that can be ordered?

A 90-day supply is the maximum amount that can be ordered at one time. Refills are kept on file for future orders. The amount that can be ordered is based on the directions and authorized quantity indicated on the original prescription written by the provider.

Is it safe to order online from Canadian Pharmacy Online?

Absolutely. All our partner pharmacies are fully licensed and certified in their respective countries. We ensure that your shopping experience is safe and secure with our Norton Shopping Guarantee. We operate just like your local pharmacy would, with our main priority being to provide you access to safe and affordable prescription medication.

Kombiglyze XR Cost

How much does Kombiglyze XR cost?

Kombiglyze XR 2.5mg/1000mg – 56 Tablets

  • Average US retail price – (60 Tablets) $520
  • Our price – $145.00

Above shows the price comparison between the average U.S. retail price and Canadian Pharmacy Online price of Kombiglyze XR 2.5 mg/1000 mg.

At CanadianPharmacyOnline.com, we make sure to keep drug prices low and cost savings are significant. 

What is the lowest price of Kombiglyze XR per unit?

Lowest Price Per Unit: $2.23/unit for Kombiglyze XR 2.5 mg/1000mg tablets 

Is this price for Kombiglyze XR without insurance?

The listed prices are not processed through insurance. Unfortunately, we cannot accept insurance. However, we will give you an official receipt which you can use to apply for reimbursement with your insurer since we are also unable to adjudicate with US insurance providers.

Why is Kombiglyze XR cheaper from Canada than from the United States?

Drug prices are negotiated and regulated in Canada. Because the US is a free market economy, the price differs since pharmaceutical suppliers can charge what they deem appropriate for the product. As a result, we can offer lower prices to our patients as we supply medications from these countries.

Kombiglyze XR Coupon

Is there an Kombiglyze XR coupon available?

Sorry, we do not have an Kombiglyze XR coupon available at this time.

Kombiglyze XR Generic

Is there a lower cost generic Kombiglyze XR available?

There currently is no generic option available on the market.

How much cheaper is generic Kombiglyze XR?

Generic drugs are often much cheaper and affordable. There is currently no generic alternative available.

What is the difference between brand and generic Kombiglyze XR?

Once available on the market, there will be no difference between generic and brand Kombiglyze XR. Generic formulations of medications contain the same active ingredients and meet the same quality, strength, and purity standards as the brand formulation.


Is shipping available to the United States?

Yes. An email notification will be sent to you once the item has been shipped. We ship nationwide across the United States. 

How much does shipping cost?

Standard shipping is free.

Is express shipping available?

If a product of Canada is available then express shipping can be selected with an estimated delivery time of 3-5 business days. You have the option at the checkout page to select the express shipping option ($25) if available for that medication source.

Refill Rx

How to refill a prescription?

Refilling your prescription is made easy with Canadian Pharmacy Online. You can sign into your online account and view your previous orders and see which prescriptions we have on file. Placing a refill order online is made simple by accessing the reorder section in your account.
You can also call us at 1-800-828-4889 and speak to customer support to place a refill. Our live chat is also a great place to connect with us to place a refill order while you are on the go.

Are prescriptions automatically refilled?

We do not automatically refill prescriptions as there can be cases where you are no longer taking the medication, your doctor has changed your dose, etc. However, we provide a friendly refill reminder service. We will kindly notify you by phone or email as to the best time to place a refill order based on your prescription history.

Drug Information

About Kombiglyze XR (Saxagliptin/Metformin)

What is Kombiglyze XR?

It is a prescription medication that is classified as a combination product containing a dipeptidyl peptidase 4 (DPP-4) inhibitor (saxagliptin) and a biguanide (metformin). 


What is Kombiglyze XR used for? 

It is used for the treatment of type 2 diabetes mellitus.

How does it work?

The saxagliptin component inhibits DPP4 which allows for increased levels of glucagon-like peptide-1 (GLP-1) which lower glucose levels in a glucose-dependent manner. Metformin increases glucose uptake and utilization to lower blood glucose levels.


How do I take Kombiglyze XR?

Take your tablet whole by mouth once daily with evening meals as directed by your doctor. Do not chew or crush the tablet.

What dosages are available?

Kombiglyze XR is available only as a brand with the saxagliptin component being immediate release and the metformin component being extended release (2.5mg/1000mg; 5mg/500mg; 5mg/1000mg).

What is the recommended dosage?

The specific dosing varies based on patient-specific factors, refer to your doctor for dosing recommendations.

What is the maximum dosage?

The maximum recommended dosage is 5mg saxagliptin/2000mg metformin per day.

What if I miss a dose?

Take the medication as soon as possible if you have missed a dose. If it is almost time for your next dose, skip the missed dose and return back to your regular schedule. Never double the dose.

Warnings & Precautions

What should you know before you take Kombiglyze XR?

Severe/disabling arthralgia has been reported with DPP-4 inhibitors. Onset can occur within a day to years after starting therapy. 

Bullous pemphigoid development has been associated with DPP-4 inhibitors.

Acute pancreatitis cases have been reported with use. 

Caution in renal function. Dose adjustment/discontinuation of therapy may be needed.

  • eGFR > 45 mL/minute/1.73m2: No dose adjustment needed. 
  • eGFR 30 to 45 mL/minute/1.73m2:
    • Initiation: Not recommended.
    • Continuation: A metformin dose reduction of 50% is needed (maximum 1 g/day) and limit saxagliptin dose to 2.5 mg/day. 
  • eGFR < 30 mL/minute/1.73m2: Use is contraindicated. 

If acute kidney injury occurs during therapy, the patient should hold the medication due to the metformin component.

Vitamin B12 deficiency has been associated with long-term metformin use. Vitamin B12 serum concentrations should be periodically monitored with long-term therapy.

U.S. Boxed Warning: Metformin-induced lactic acidosis have been reported in postmarketing cases that have resulted in death. The risk is increased with renal dysfunction.

Side Effects

What are the side effects of Kombiglyze XR?

Some common side effects include:

  • Abdominal pain, diarrhea, nausea
  • Headache
  • Upper respiratory tract infection

Speak to your doctor for a full list of side effects that apply to you if you are taking this medication.


Does this medication interact with other drugs, foods, or alcohol?

Avoid use with alcohol due to increased risk of lactic acidosis with metformin (Risk Category X).

This is not a full list of potential drug-drug-interactions. Speak to your doctor if you have any concerns about drug-drug-interactions. 


How should this medication be stored?

It should be stored between 20-25°C (68-77°F). Excursions are allowed to be stored between 15-30°C (59-86°F).

Pharmacist Tips

  • Take with food to decrease the risk of any gastrointestinal side effects due to the metformin component of the medication. 
  • Do not chew or crush the tablet. 

The above information is an educational aid only. It is not intended as medical advice for individual conditions or treatments. Talk to your doctor, nurse or pharmacist before following any medical regimen to see if it is safe and effective for you.


Save $10 on your first order!
Enter Canadian Pharmacy Online coupon code CPO10 to save $10 off your order. Minimum $50 order value. *Coupon codes are one-time use and cannot be combined.

Kombiglyze XR FAQ

Is Kombiglyze XR insulin?

No. It is composed of saxagliptin (DDP-4 inhibitor) and metformin (biguanide).

How does Kombiglyze XR work in the body?

This medication works by decreasing the amount of sugar your liver releases in your body and increases your body’s insulin sensitivity.

What class of drug is Kombiglyze XR?

It is made up of two drug classes, a DDP-4 inhibitor and biguanide.

Does Kombiglyze XR cause weight gain?

No. Weight gain is not a listed side effect.

What is Kombiglyze XR used for?

It is used for the treatment of type 2 diabetes mellitus.

The above information is an educational aid only. It is not intended as medical advice for individual conditions or treatments. Talk to your doctor, nurse or pharmacist before following any medical regimen to see if it is safe and effective for you.