Saphris (Asenapine Maleate)

Rx Prescription Required

Select your dosage below to view Saphris price and place your order. Save up to 90% and get FREE standard shipping on prescription medication delivered to your door.

Asenapine Maleate 10mg
Asenapine Maleate
Sun Pharmaceuticals Ltd
Saphris 5mg
Asenapine Maleate
Merck Sharp & Dohme
Saphris 10mg
Asenapine Maleate
Merck Sharp & Dohme
Saphris 5mg
Asenapine Maleate
Merck Sharp & Dohme
Saphris 10mg
Asenapine Maleate
Merck Sharp & Dohme


Medically reviewed by Dr. Samuel Maaiah, PharmD

Last updated: April 10, 2024

Dr. Maaiah is a PharmD graduate who has practiced both in pharmaceutical consulting and retail pharmacy. His interests include consulting and the development and approval of new therapeutics. He currently works as a Medical Information Consultant (MIC) and as a retail pharmacist. As a MIC he helps pharmaceutical companies with projects and by consulting as a medical information expert.

When Dr. Maaiah is not working, he enjoys spending time with his family and friends, doing outdoor activities, working out, and reading.

Order Online

How to buy Saphris (Asenapine) online?

Saphris (Asenapine) can be ordered online through or by calling 1-800-828-4489 and speaking to customer support. The chat feature can also be used for support. For more information please visit the “How to Order” page.

Is a prescription required?

Yes, a valid prescription from your doctor is required. Saphris (Asenapine) is a prescription medication and can only be sold with a prescription. To process your order, you will need to submit a prescription. The prescription can be emailed ([email protected]), faxed (1-800-416-8019), or uploaded. Alternatively, we can reach out to your doctor to attain a valid prescription if you would like.

What is the maximum amount that can be ordered?

A 3-month supply (90 days) is the maximum amount that can be ordered at one time. Refills are kept on file for future orders. The amount that can be ordered will be based on the directions and quantity indicated on the prescription from your provider.

Is it safe to order from Canadian Pharmacy Online?

Absolutely. All our partner pharmacies are fully licensed and certified in their respective countries. We ensure that your shopping experience is safe and secure with our Norton Shopping Guarantee. We operate just like your local pharmacy would, with our main priority being to provide you access to safe and affordable prescription medication.

Saphris Cost

How much does Saphris (Asenapine) cost?

Saphris 10mg – 60 Tablets

  • Average US retail price – $1440.97
  • Our Price – $203.00

At, we make sure to keep drug prices low. You can view the Saphris (Asenapine) cost savings below:

We provide brand Saphris (Asenapine) 10 mg tablets here at Canadian Pharmacy Online. A quantity of 60 tablets of brand Saphris (Asenapine) costs $203, which comes out to $3.38 per unit.

Below shows the price comparison of brand Saphris (Asenapine) 10 mg tablets at a quantity of 60 tablets between the average U.S. retail price and Canadian Pharmacy Online price.

What is the lowest price of Saphris (Asenapine) per unit?

Lowest Price Per Unit: $2.92/unit for brand Saphris (Asenapine) 10 mg tablets

Is this price for Saphris (Asenapine) without insurance?

The listed prices above are not processed through insurance since we are unable to process insurance claims. However, we will give you an official receipt which you can use to apply for reimbursement with your insurer. We are also unable to adjudicate with US insurance providers.

Why is Saphris (Asenapine) cheaper from Canada than from the United States?

Drug prices are negotiated and regulated in Canada. Because the US is a free market economy, the price differs since pharmaceutical suppliers can charge what they deem appropriate for the product. As a result, we can offer lower prices to our patients as we supply medications from these countries. 

Saphris Coupon

Is there a coupon for Saphris available?

Sorry, we do not have a Saphris coupon available at this time.

Saphris Generic

Is there a lower cost generic Saphris (Asenapine) available?

Saphris (Asenapine) is available as a generic alternative.

How much cheaper is generic Saphris (Asenapine)?

Generic Saphris (Asenapine) is not available through 90-Day Meds.

What is the difference between brand and generic Saphris (Asenapine)?

There is no difference between generic and brand Saphris (Asenapine). Generic formulations of medications contain the same active ingredients and meet the same quality, strength, and purity standards as the brand formulation.


Is shipping available to the United States?

Yes. An email notification will be sent to you once the item has been shipped. We ship nationwide across the United States.

How much does shipping cost?

There are no standard shipping fees.

Is express shipping available?

If a product of Canada is available then express shipping can be selected with an estimated delivery time of 3-5 business days. You have the option at the checkout page to select the express shipping option ($25) if available for that medication source.

Refill Rx

How to refill a prescription?

Refilling your prescription is made easy with Canadian Pharmacy Online. You can sign into your online account and view your previous orders and see which prescriptions we have on file. Placing a refill order online is made simple by accessing the reorder section in your account.

You can also call us at 1-800-416-8019 and speak to customer support to place a refill. Our live chat is also a great place to connect with us to place a refill order while you are on the go.

Are prescriptions automatically refilled?

We do not automatically refill prescriptions as there can be cases where you are no longer taking the medication, your doctor has changed your dose, etc. However, we provide a friendly refill reminder service. We will kindly notify you by phone or email as to the best time to place a refill order based on your prescription history.

Drug Information

About Saphris (Asenapine)

What is Saphris (Asenapine)?

Saphris (Asenapine) is a prescription medication that is classified as an atypical antipsychotic.


What is Saphris (Asenapine) used for? 

It is used to treat schizophrenia in adults and bipolar 1 disorder in patients aged 10 and up. For the treatment of Bipolar 1 Disorder, it can be used as acute monotherapy for mixed or manic episodes, in combination with lithium or valproate in adults, and as maintenance monotherapy in adult patients.

How does it work? 

Saphris helps treat the symptoms of bipolar 1 disorder by antagonizing D2 and 5-HT2a activity.


How do I take Saphris (Asenapine)?

This medication is taken sublingually which means that you should allow the tablet to dissolve under the tongue. This medication should dissolve fairly quickly. Make sure your hands are dry when handling this medication as moisture may cause the tablet to dissolve prematurely. Do not eat or drink anything for at least 10 minutes after taking a dose of this medication.

What dosages are available?

Saphris (Asenapine) is available as brand and generic 2.5 mg, 5 mg, and 10 mg sublingual tablets.

What is the recommended dosage?

Typically one 5 mg dose is given twice daily but take as directed by your doctor.

What is the maximum dosage?

The maximum recommended dosage is 20 mg/day.

What if I miss a dose?

If you miss a dose of this medication, take your dose as soon as you remember unless it is time for your next scheduled dose. In that case, just take your scheduled dose and skip your missed dose but do not double your dose to compensate.

Warnings & Precautions

What should you know before you take Saphris (Asenapine)?

In elderly patients with dementia-related psychosis, there is an increased risk for cerebrovascular events

If symptoms of neuroleptic malignant syndrome emerge, immediately discontinue

There is a risk for tardive dyskinesia; discontinue if appropriate

This medication may cause metabolic changes. Monitor for diabetes, dysplipidemia, and/or weight gain

There is a risk for orthostatic hypotension; monitor heart rate and blood pressure. Increased risk for orthostatic hypotension if dehydrated

In patients with low WBC, CBC monitoring may be warranted. If there is a significant, inexplicable decline in WBC count, consider discontinuing Saphris

This medication may cause QT prolongation; use caution in patients at high risk for QT prolongation and/or if on other QT-prolonging medications

Use caution in patients with seizures or are taking medications that lower the seizure threshold

Use caution when driving or operating heavy machinery

Side Effects

What are the side effects of Saphris (Asenapine)?

Some common side effects (≥ 5%) include:

  • Akathisia
  • Oral hypoesthesia
  • Somnolence
  • Dizziness
  • Extrapyramidal symptoms
  • Dysguesia
  • Oral paresthesia
  • Nausea
  • Increased appetite
  • Fatigue
  • Increased weight

Speak to your doctor for a full list of side effects.


Does this medication interact with other drugs, foods, or alcohol?

Use caution if on other anti-hypertensive medications as Saphris can cause hypotension

If used concomitantly with paroxetine, reduce paroxetine dose by 50%


How should this medication be stored?

Keep Saphris (Asenapine) in the original container and store it in a dry place at room temperature 15-30°C (59-86°F).

Pharmacist Tips

  • Your dose may need to be adjusted several times before your doctor finds the right dose for you. Follow the tapering schedule your doctor prescribes as they may be trying to slowly increase the dose in you.
  • Discontinue this medication and seek medical attention if you experience any allergic symptoms after taking Saphris. Symptoms include: difficulty breathing, itching, facial swelling, or swelling of lips/tongue/throat.
  • Symptoms of neuroleptic malignant syndrome include: hyperpyrexia, muscle rigidity, altered mental status, and autonomic instability. Seek medical attention if any of these symptoms emerge.
  • Take this medication at the same time(s) each day to prevent missed doses. If you miss multiple doses consecutively, alert your doctor as they may want to re-taper the medication to prevent side effects.

The above information is an educational aid only. It is not intended as medical advice for individual conditions or treatments. Talk to your doctor, nurse or pharmacist before following any medical regimen to see if it is safe and effective for you.


Save $10 on your first order!
Enter Canadian Pharmacy Online coupon code CPO10 to save $10 off your order. Minimum $50 order value. *Coupon codes are one-time use and cannot be combined.

Saphris FAQ

How long does Saphris take to dissolve?

It should completely dissolve within seconds but it is advised to not eat or drink anything for at least 10 minutes after the dose is given in case there is still medication in your mouth needing to be dissolved.

Does Saphris make you gain weight?

Yes, some patients have reported weight gain after taking this medication.

Does Saphris help anxiety?

This medication is an antipsychotic that is used to treat certain mood disorders. It can indirectly help reduce anxiety by allowing patients to think more clearly and decrease hallucinations.

Can you stop Saphris cold turkey?

It is not recommended to stop taking Saphris suddenly as this may precipitate withdrawal symptoms. You may slowly wean off the medication under medical supervision and provider approval.

Can Saphris work if swallowed?

This medication should not be split, crushed, chewed, or swallowed per its package insert.

The above information is an educational aid only. It is not intended as medical advice for individual conditions or treatments. Talk to your doctor, nurse or pharmacist before following any medical regimen to see if it is safe and effective for you.